Jiali Xing

Applications and advances of bile-based omics technologies in the diagnosis of cholangiocarcinoma

Taifeng Zhu, Jiali Xing, Ziyue Huang, Shanshan Wang et autres

Cholangiocarcinoma (CCA) is challenging to diagnose due to its subtle symptoms and the limited sensitivity and specificity of conventional diagnostic modalities. Therefore, there is an urgent need for more effective detection strategies. Bile, a fluid directly secreted by the biliary system, offers …

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Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients

Baoluhe Zhang, Bao Jin, Xueshuai Wan, Xiao Liu et autres

BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive biliary tract cancer with limited treatment options, underscoring the need for breakthrough precision therapies. Neoantigen-based therapy is a promising novel strategy for cancer treatment. This study investigates the potential of neoantigen peptides in CCA, emphasizing their …

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Urinary biomarkers in cancer detection: explorations, advancements, challenges, and future directions

Weixuan Pan, Jiali Xing, Xiaokun Chen, Runzhe Xue et autres

Urine, a rich biological resource containing diverse metabolites, proteins, exfoliated cells, and cell-free DNA, provides valuable insights into physiological and pathological states. Its noninvasive nature and ease of collection have established urinary biomarkers as promising tools for detecting urological cancers, particularly bladder, …

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Hormone replacement therapy in endometrial cancer survivors: A retrospective cohort study on recurrence, survival, and quality of life

Jiali Xing, Qi Liu, Li Qiao

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Progress in the Application of Urine Proteomics in Cancer Biomarker Discovery

Jiali Xing, Xueshuai Wan, Xinting Sang, Shunda Du et autres

Urine testing has been used as a noninvasive, economical tool for disease screening, diagnosis, and surveillance. With the progress of urine detection technology, modern analysis platforms have effectively measured urinary proteomics, which can be used better to understand the pathophysiology and clinical …

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Novel multifactor predictive model for postoperative survival in gallbladder cancer: a multi-center study

Kaige Deng, Jiali Xing, Gang Xu, Ruixue Ma et autres

BACKGROUND: Gallbladder cancer (GBC) is a highly aggressive malignancy, with limited survival profiles after curative surgeries. This study aimed to develop a practical model for predicting the postoperative overall survival (OS) in GBC patients. METHODS: Patients from three hospitals were included. Two …

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Multicellular 3D bioprinted human gallbladder carcinoma for in vitro mimicry of tumor microenvironment and intratumoral heterogeneity

Yukai Jin, Jiangang Zhang, Jiali Xing, Yiran Li et autres

Abstract Gallbladder carcinoma (GBC) is a malignant hepatobiliary cancer characterized by an intricate tumor microenvironments (TME) and heterogeneity. The traditional GBC 2D culture models cannot faithfully recapitulate the characteristics of the TME. Three-dimensional (3D) bioprinting enables the establishment of high-throughput and high-fidelity …

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Discovering urinary protein biomarkers for hepatocellular carcinoma in the population of patients with chronic hepatitis B: A single-center case-control study.

Yuke Zhang, Yongfa Huang, Jiali Xing, Yüxin Wang et autres

e16230 Background: Chronic hepatitis B (CHB) can result in hepatocellular carcinoma (HCC) imposing a substantial health and economic burden worldwide. Early detection of hepatitis B virus-related HCC (HBV-HCC) in CHB with potential biomarkers has emerged as an urgent and challenging task. Recent …

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Novel Multi-factor Predictive Model for Postoperative Survival in Gallbladder Cancer: A Multi-Center Study

Kaige Deng, Jiali Xing, Gang Xu, Bao Jin et autres

Abstract Background and study purpose: Gallbladder cancer (GBC) is a highly aggressive malignancy, and surgery is the primary curative option. However, postoperative survival of patients with GBC remains limited. This study aimed to develop a practical model for predicting the postoperative overall …

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Urinary biomarkers for hepatocellular carcinoma: current knowledge for clinicians

Kaige Deng, Jiali Xing, Gang Xu, Bao Jin et autres

Hepatocellular carcinoma (HCC) is the most predominant primary liver cancer, causing many illnesses and deaths worldwide. The insidious clinical presentation, difficulty in early diagnosis, and the highly malignant nature make the prognosis of HCC extremely poor. The complex and heterogeneous pathogenesis of …

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Application and Progress of Cultured Models of Gallbladder Carcinoma

Jiali Xing, Peiwen Ding, Xueshuai Wan, Gang Xu et autres

Gallbladder carcinoma (GBC) is a malignant tumor of the biliary system that is aggressive, difficult to detect early, and has a low surgical resection rate and poor prognosis. Appropriate in vitro growth models are expected to focus on the study of the …

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Management of Patients with Chronic Liver Disease in the Perioperative Period

Jiali Xing, Xueshuai Wan, Huayu Yang, Shunda Du

To the Editor:We read with great interest the results of comparing postoperative complications of non-liver surgery in patients with chronic liver disease(CLD) and those without chronic liver disea...

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