Mitchell J. Moon

Platelet membrane microbubbles as ultrasound imaging-trackable colloidal agents for clot targeting and detection

Mark Louis Vidallon, Mitchell J. Moon, Haikun Liu, Yuyang Song et autres

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Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19 F MRI Feasibility (Small 11/2026)

Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh et autres

Ultrasound-Responsive mRNA Nanocarriers In article number e6806, Mark Louis P. Vidallon, Xiaowei Wang, and co-workers introduce nanodroplets for ultrasound-guided mRNA delivery. Trackable by ultrasound and fluorine-19 magnetic resonance imaging, the nanodroplets transform into microbubbles upon acoustic activation, enabling real-time imaging and localized …

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Mapping Hydration and Nanoarchitecture in mRNA‐Loaded Lipid Nanoparticles Through Small‐Angle Neutron Scattering

Haikun Liu, Mark Louis P. Vidallon, Sylvain Trépout, Marina Cagnes et autres

mRNA‐loaded lipid nanoparticles (LNPs) offer significant therapeutic potential for various diseases, yet their structural characteristics and component distribution remain incompletely understood. This study utilizes small‐angle neutron scattering (SANS) to explore the internal architecture of KC2 LNPs, employing deuterated lipid substitutions in contrast‐varied …

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Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19 F MRI Feasibility

Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh et autres

Messenger RNA (mRNA) therapeutics provide promising opportunities in cardiovascular diseases. However, effective vascular mRNA delivery requires precise delivery, controlled release, and efficient transfection. To address these challenges, the study utilizes phase-change perfluorocarbon nanodroplets (PFC NDs) as a unique theranostic platform, integrating multimodal …

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Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation

Johannes Zeller, Julia Loseff-Silver, Khashayar Khoshmanesh, Sara Baratchi et autres

BACKGROUND: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity. Pathophysiological shear rates as observed in aortic valve stenosis (AS) …

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Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes

Mark Louis P. Vidallon, Mitchell J. Moon, Haikun Liu, Yuyang Song et autres

High Resolution Image Download MS PowerPoint Slide Thrombosis-related cardiovascular diseases remain the leading global cause of mortality and morbidity. In this study, we present a pioneering approach in the field of nanobiotechnology, with a focus on clinical translation, aimed at advancing early …

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Revealing the Structural Intricacies of Biomembrane‐Interfaced Emulsions with Small‐ and Ultra‐Small‐Angle Neutron Scattering

Mark Louis P. Vidallon, Ashley P. Williams, Mitchell J. Moon, Haikun Liu et autres

Abstract Utilizing cell membranes from diverse cell types for biointerfacing has demonstrated significant advantages in enhancing colloidal stability and incorporating biological properties, tailored specifically for various biomedical applications. However, the structures of these materials, particularly emulsions interfaced with red blood cell (RBC) …

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Neutron Scattering Strategies for Investigating Internal Architecture of mRNA Lipid Nanoparticle

Haikun Liu, Mark Louis P. Vidallon, Sylvain Trépout, Mitchell J. Moon et autres

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Revealing the Structural Intricacies of Biointerfaced Emulsions with Neutron Scattering

Mark Louis P. Vidallon, Ashley P. Williams, Mitchell J. Moon, Haikun Liu et autres

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Differential effects of physiological agonists on the proteome of platelet‐derived extracellular vesicles

Mitchell J. Moon, Alin Rai, Prerna Sharma, Haoyun Fang et autres

Arterial thrombosis manifesting as heart attack and stroke is the leading cause of death worldwide. Platelets are central mediators of thrombosis that can be activated through multiple activation pathways. Platelet-derived extracellular vesicles (pEVs), also known as platelet-derived microparticles, are granular mixtures of …

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Weaponizing platelets for cancer treatment: Converting allies to deadly foes!

Mitchell J. Moon, Julia I. Skoraczynski, Karlheinz Peter

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Activated Coagulation FXII: A Unique Target for In Vivo Molecular Imaging

Aidan P. G. Walsh, Eefang Yu, James D. McFadyen, Viktoria Bongcaron et autres

Background: Current clinical imaging of thromboembolic diseases often relies on indirect detection of thrombi, which may delay diagnosis and ultimately the institution of beneficial, potentially lifesaving treatment. Therefore, the development of targeting tools that facilitate the rapid, specific, and direct imaging of …

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