Richard O. C. Oreffo

Decoupled ionic clearance pathways determine the in vivo fate of a synthetic nanoclay-BMP-2 biomaterial during ectopic bone induction

Yang‐Hee Kim, Juan Aviles Milan, Janos M. Kanczler, Agnieszka A. Janeczek et autres

IVIS, muCT and ICP MS datasets

gb, sa (code pays fourni par la source)

Decoupled ionic clearance pathways determine the in vivo fate of a synthetic nanoclay-BMP-2 biomaterial during ectopic bone induction

Yang‐Hee Kim, Juan Aviles Milan, Janos M. Kanczler, Agnieszka A. Janeczek et autres

IVIS, muCT and ICP MS datasets

gb, sa (code pays fourni par la source)

Decoupled ionic and particulate clearance pathways determine the in vivo fate of a synthetic nanoclay-BMP-2 biomaterial during ectopic bone induction

Yang‐Hee Kim, Juan Aviles Milan, Janos Kanczler, Agnieszka Janeczek et autres

Abstract Nanoclay-based biomaterials offer promise for localised growth factor presentation, yet their in vivo degradation, clearance, and systemic fate remain poorly defined. Here, we investigate the fate of a synthetic nanoclay-BMP-2 gel during ectopic bone induction using a combination of in vivo …

gb (code pays fourni par la source)

Ion-mediated progressively stiffening hydrogels for vascularized bone regeneration

Wenhuan Bu, Jonathan I. Dawson, Richard O. C. Oreffo, Matteo D’Este et autres

gb, ch, fr, cn (code pays fourni par la source)

Localized growth factor delivery from microparticles modulates osteogenic and chondrogenic gene expression in a growth factor-dependent manner in an ex vivo chick embryonic bone model

Hassan Rashidi, Helen C. Cox, Omar Qutachi, DALE A. MOULDING et autres

Growth factors play a crucial role in regulating various cellular functions, including proliferation and differentiation. Consequently, the biomaterial-based delivery of exogenous growth factors presents a promising strategy in regenerative medicine to manage the healing process and restore tissue function. For effective therapeutic …

gb, es (code pays fourni par la source)

Bioactive elastin-like-recombinamer (ELR) membranes guide bone regeneration in rabbit critical size calvarial defects

Vasiliki P. Koidou, Shakeel A. Shahdad, Mital Patel, Stuart Lanham et autres

OBJECTIVES: To examine the effectiveness of non-mineralised and pre-mineralised elastin-like recombinamer (ELR) membranes in guided bone regeneration (GBR) in a pre-clinical rabbit model. MATERIALS AND METHODS: Three pre-mineralised ELR membranes (D1, D2 and D8) and a non-mineralised (D0) membrane, along with a …

gb, es (code pays fourni par la source)

Characterising Type I Collagen Architecture in Human Bone and Osteosarcoma with Second Harmonic Generation Microscopy

Belle Creith, James Harrison, Peter Johnson, Richard O. C. Oreffo et autres

Aberrant collagen matrix production is a hallmark of many cancers, including osteosarcoma (OS), the most common primary cancer of bone which remains poorly diagnosed. Here, the phenotyping potential of second harmonic generation (SHG) microscopy has been demonstrated through label-free imaging of pathologically …

gb (code pays fourni par la source)

ORTHOPAEDICS AND ADDITIVE MANUFACTURING: DOES IT ALL ADD UP?

D. Dunlop, Richard O. C. Oreffo

Advancements in 3D printing, known as additive manufacturing (AM), has allowed for the production of highly porous Trabecular Metals (TM) that aim to ‘mimic’ human bone allowing bony in-growth. AM is being increasingly used to produce acetabular implants with a TM surface …

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Novel Biomolecular techniques in the analysis of Orthopaedic trabecular metal implants produced by additive manufacturing

Richard O. C. Oreffo, D. Dunlop

Abstract Recent trends have seen an increase in the use of orthopaedic acetabular implants produced by additive manufacturing. These implants utilise novel trabecular metals with seemingly large variations in their structural designs. There is no available biomolecular comparisons between these different implants. …

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Localized Growth Factor Delivery from Microparticles Modulates Osteogenic and Chondrogenic Gene Expression in a Growth Factor-Dependent Manner in an ex vivo Chick Embryonic Bone Model

Hassan Rashidi, Helen C. Cox, Omar Qutachi, DALE A. MOULDING et autres

gb, es (code pays fourni par la source)

Isolation, Differentiation, and Characterization of Human Bone Marrow Stromal Stem Cells In Vitro and In Vivo

Janos M. Kanczler, Rahul S. Tare, Howard C. Tribe, Patrick S. Stumpf et autres

gb (code pays fourni par la source)

Harnessing Raman spectroscopy and multimodal imaging of cartilage for osteoarthritis diagnosis

Anna Crisford, Hiroki Cook, Konstantinos Nikolaos Bourdakos, Seshasailam Venkateswaran et autres

Abstract Osteoarthritis (OA) is a complex disease of cartilage characterised by joint pain, functional limitation, and reduced quality of life with affected joint movement leading to pain and limited mobility. Current methods to diagnose OA are predominantly limited to X-ray, MRI and …

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