Qianqian Lou

H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation

Yan Xi, Shuai-Shuai Pei, Qianqian Lou, Sheng Li et autres

Embryonic stem cells (ESCs) are refractory to inflammatory stimuli but acquire inflammatory competence upon differentiation, yet the underlying mechanisms remain unclear. Here, we report that H2BK5ac regulates the acquisition of inflammatory potential in mouse ESCs during differentiation. H2BK5ac levels increased at the …

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H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation | Original Western Blot Raw Images

Yan Xi, Shuai-Shuai Pei, Qianqian Lou, li sheng et autres

This dataset contains the original, unprocessed Western blot raw images corresponding to the research article entitled “H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation”. All raw blot files were directly exported from the imaging …

H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation | Original Western Blot Raw Images

Yan Xi, Shuai-Shuai Pei, Qianqian Lou, li sheng et autres

This dataset contains the original, unprocessed Western blot raw images corresponding to the research article entitled “H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation”. All raw blot files were directly exported from the imaging …

A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice

W. Dong, Ping-Kai Cheng, Jiamin Miao, Pei Shi et autres

Rancid odors can trigger retching and aversion in humans that prevent consumption of spoiled food, and consequently metabolic dysregulation, but the underlying neural mechanisms remain unclear. Here, we show that exposure to 2-methylbutyric acid (2MBA) odor triggers such defensive responses in male …

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Tip60-HDAC8-SMURF2-mediated β-TrCP1 degradation is a key mechanism for hypoxia-induced cell death and tissue injury

Sheng Li, Sheng Li, B Zhang, Zi-Juan Wei et autres

The accumulation of HIFs regulated by the PHD-pVHL pathway represents the classical mechanism that transcriptionally mediates cellular adaptation to hypoxia. Extensive hypoxic stress activates cell death. Comprehensive understanding the mechanisms of hypoxia-induced cell death is essential for treatment of several diseases. Here, …

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Galectin-related protein, a key contributor, drives diabetes-associated neuropathic pain

Danyang Chen, Jing Wang, Xiang-Jie Song, Zijiao Ding et autres

Neuropathic pain associated with central sensitization is common in diabetic patients, but the underlying mechanisms remain unclear. Here, a proteomics screen identified a previously uncharacterized protein, galectin-related protein (LGALSL), which was significantly upregulated in cerebrospinal fluid and extracellular fluid of the anterior …

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A neural circuit for sex-dependent conditioned pain hypersensitivity in mice

Mingjun Zhang, Ziyun Ni, Jun Ma, An Liu et autres

The neural mechanisms underlying sex-specific pain, in which males and females exhibit distinct responses to pain, remain poorly understood. Here we show that in a mouse model of male-specific pain hypersensitivity response to pain conditioning environments (contextual pain hypersensitivity model), elevated free-testosterone …

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A noradrenergic pathway for the induction of pain by sleep loss

Qianqian Lou, Hong-Rui Wei, Danyang Chen, Yuzhuo Zhang et autres

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Protocol to test for the formation of ternary protein complexes in vivo or in vitro using a two-step immunoprecipitation approach

B Zhang, Zi-Juan Wei, Qianqian Lou, Yue Liu et autres

Co-immunoprecipitation (coIP) is an experimental technique to study protein-protein interactions (PPIs). However, single-step coIP can only be used to identify the interaction between two proteins and does not solve the interaction testing of ternary complexes. Here, we present a protocol to test …

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ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells

Sheng Li, B Zhang, Qianqian Lou, Yue Liu et autres

Embryonic stem cells (ESCs), with abilities of infinite proliferation (self-renewal) and to differentiate into distinct cell types (pluripotency), show attenuated inflammatory response against cytokines or pathogens, which is recognized as a unique characteristic of ESCs compared with somatic cells. However, the underlying …

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Chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex

Danyang Chen, Liang Shen, Yu-Zhuo Zhang, Bu-Fan Kan et autres

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Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

Danyang Chen, Qianqian Lou, Xiang-Jie Song, Fang Kang et autres

Abstract Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with stress to achieve the extinction of anxiety are not clear. Here we show that acute restraint stress causes an …

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