Jan Schouten

Multiplexable, High-Throughput DNA-Based Technologies in Screening and Confirmatory Testing of Newborn Conditions: A Scoping Review

Terence Diane Fabella, Joery den Hoed, Lidewij Henneman, Wendy Rodenburg et autres

Newborn screening (NBS) is evolving as novel technologies offer the opportunities to include a broader range of treatable disorders in its programs. Multiplexable, high-throughput DNA-based technologies such as next-generation sequencing (NGS) are being explored to improve and expand disease detection, although several …

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Safety, effectiveness, and cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (BICAT-NL study): a multicentre, non-inferiority, randomised controlled trial

Lindsay S. Spekreijse, Rob W.P. Simons, Björn Winkens, Frank van den Biggelaar et autres

nl, tw (code pays fourni par la source)

Abstract 2934: BYON4228, an antagonistic SIRPα mAb with a unique and favorable preclinical profile compared to three comparator SIRPα mAbs

Mary van Helden, Seline A. Zwarthoff, Roel Arends, Inge Reinieren-Beeren et autres

Abstract A growing body of data from early clinical studies supports that targeting the myeloid immune checkpoint CD47-SIRPα represents a successful strategy towards establishing effective new therapies for cancer patients. Initial studies focused on CD47 blockers and more recently also SIRPα antagonistic …

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BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells

Mary J. van Helden, Seline A. Zwarthoff, Roel J. Arends, Inge Reinieren-Beeren et autres

Background Preclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. However, CD47 is ubiquitously expressed and mediates functional interactions …

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Economic evaluation of prevention of cystoid macular edema after cataract surgery in diabetic patients: ESCRS PREMED study report 6

Rob W.P. Simons, Laura H.P. Wielders, Rudy M.M.A. Nuijts, Claudette A. Veldhuizen et autres

PURPOSE: To investigate the cost-effectiveness of prophylactic treatments against cystoid macular edema after cataract surgery in diabetic patients. SETTING: 7 ophthalmology clinics in the Netherlands and Belgium. DESIGN: Prospective trial-based cost-effectiveness analysis using data from a European multicenter randomized clinical trial. METHODS: …

nl, us, de, gb, tw (code pays fourni par la source)

Effect of combined water drinking test and dark room provocative testing in Caucasian eyes with narrow angles

Hellen C.S. Römkens, Henny J. M. Beckers, Jan Schouten, Tos T. J. M. Berendschot et autres

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Economic evaluation of prevention of cystoid macular edema after cataract surgery in patients without diabetes: ESCRS PREMED study report 4

Rob W.P. Simons, Laura H.P. Wielders, Carmen D. Dirksen, Claudette A. Veldhuizen et autres

PURPOSE: To investigate the cost-effectiveness of prophylactic treatments against cystoid macular edema (CME) after cataract surgery in patients without diabetes. SETTING: Seven ophthalmology clinics in the Netherlands and Belgium. DESIGN: Prospective cost-effectiveness analysis using data from a European multicenter randomized clinical trial …

nl (code pays fourni par la source)

A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines

Ruud G. E. Coumans, G.J.A. Ariaans, Henri Spijker, Pascal Renart Verkerk et autres

Abstract Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the therapeutic index and helps to streamline the manufacturing process. Here, we report the development of an in silico …

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Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study

Frank Cornelis Theodorus van der Heide, Tan Lai Zhou, Ronald M.A. Henry, Alfons J.H.M. Houben et autres

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Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients

Palwasha Mokhles, Luuk van Gorcom, Jan Schouten, Tos T. J. M. Berendschot et autres

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Intragenic and structural variation in the SMN locus and clinical variability in spinal muscular atrophy

Renske I. Wadman, Marc Jansen, Marloes Stam, Camiel A. Wijngaarde et autres

Abstract Clinical severity and treatment response vary significantly between patients with spinal muscular atrophy. The approval of therapies and the emergence of neonatal screening programmes urgently require a more detailed understanding of the genetic variants that underlie this clinical heterogeneity. We systematically …

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The frequency of SMN gene variants lacking exon 7 and 8 is highly population dependent

Raymon Vijzelaar, Reinier Snetselaar, Martijn J. A. M. Clausen, Amanda G. Mason et autres

Spinal Muscular Atrophy (SMA) is a disorder characterized by the degeneration of motor neurons in the spinal cord, leading to muscular atrophy. In the majority of cases, SMA is caused by the homozygous absence of the SMN1 gene. The disease severity of …

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