Wale A R Sulaiman

MicroRNA Regulatory Network as Biomarkers of Late Seizure in Patients with Spontaneous Intracerebral Hemorrhage

Ifeanyi O. Iwuchukwu, Doan H. Nguyen, Michelle Beavers, Vi Tran et autres

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Single Local Application of TGF-β Promotes a Proregenerative State Throughout a Chronically Injured Nerve

Wale A R Sulaiman, Thomas D. Dreesen, Doan H. Nguyen

BACKGROUND: The lack of nerve regeneration and functional recovery occurs frequently when injuries involve large nerve trunks because insufficient mature axons reach their targets in the distal stump and because of the loss of neurotrophic support, primarily from Schwann cells (SCs). OBJECTIVE: …

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Micro RNA Profile in Cerebrospinal Fluid and Plasma of Patients with Spontaneous Intracerebral Hemorrhage

Ifeanyi O. Iwuchukwu, Doan H. Nguyen, Wale A R Sulaiman

Spontaneous intracerebral hemorrhage (ICH) accounts for 15–20% of "acute stroke" with a significant morbidity and mortality 1. Following ICH, pathobiological processes (blood–brain barrier (BBB) damage, cerebral edema, and inflammation) are activated 1, 2. The molecular changes associated with these processes could be …

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Transforming Growth Factor-β Promotes Axonal Regeneration After Chronic Nerve Injury

Wale A R Sulaiman

When spinal cord injury (SCI) occurs, injured cells must survive and regenerate to close gaps caused by the injury and to create functional motor units. After peripheral nerve injury, Wallerian degeneration in the distal nerve stump creates a neurotrophic and growth-supportive environment …

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Breaking Through the “Glass Ceiling” of Minimally Invasive Spine Surgery

Frank M. Phillips, Ivan Cheng, Yoga Raja Rampersaud, Behrooz A. Akbarnia et autres

Spine is an international, peer-reviewed, bi-weekly periodical that considers for publication original articles in the field of spine. It is the leading subspecialty journal for the treatment of spinal disorders. Only original papers are considered for publication with the understanding that they …

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Transforming growth factor beta 1, a cytokine with regenerative functions

Wale A R Sulaiman, DoanH Nguyen

We review the biology and role of transforming growth factor beta 1 (TGF-β1) in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks (i.e., sciatic nerve, brachial plexus), which often leads to suboptimal functional recovery. Experimental studies …

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Effect of local application of transforming growth factor–β at the nerve repair site following chronic axotomy and denervation on the expression of regeneration-associated genes

Wale A R Sulaiman, Thomas D. Dreesen

OBJECTIVES: Although peripheral nerves can regenerate after traumatic injury, functional recovery is often suboptimal, especially after injuries to large nerve trunks such as the sciatic nerve or brachial plexus. Current research with animal models suggests that the lack of functional recovery resides …

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Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis grades 1-2: patient-reported clinical outcomes and cost-utility analysis.

Wale A R Sulaiman, Manish Singh

BACKGROUND: Transforaminal lumbar interbody fusion (TLIF) is the standard surgical treatment for patients with lumbar degenerative spondylolisthesis who do not respond to a 6-week course of conservative therapy. A number of morbidities are associated with the conventional open-TLIF method, so minimally invasive …

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Intraoperative neurophysiological monitoring for minimally invasive 1- and 2-level transforaminal lumbar interbody fusion: does it improve patient outcome?

Juanita Garces, John F. Berry, Edison P. Valle-Giler, Wale A R Sulaiman

BACKGROUND: Despite the widespread use of intraoperative monitoring (IOM) in many types of spinal surgeries, an absence of data comparing monitored a nd unmonitored postoperative outcomes places IOM's efficacy into question. A lack of consensus among surgeons about when to use monitoring …

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Midline minimally invasive placement of spinal cord stimulators: a technical note.

Edison P. Valle-Giler, Wale A R Sulaiman

BACKGROUND: Spinal cord stimulators (SCSs) have conventionally been implanted through open approaches requiring extensive muscle dissection to perform laminectomies and permanently place the paddle lead. This approach could contribute to worsening the pain syndrome in patients who experience chronic pain. In an …

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From the Editor's Desk.

Wale A R Sulaiman

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One-stage resection of giant invasive thoracic schwannoma: case report and review of literature.

Edison P. Valle-Giler, Juanita Garces, Roger Douglas Smith, Wale A R Sulaiman

BACKGROUND: Schwannomas comprise approximately 25% of all spinal tumors, being the third most frequent soft-tissue tumor after hemangiomas and lipomas. Grade 5 invasive giant schwannomas erode the vertebral bodies, involve 2 or more levels, and invade the myofascial planes. Because 3 compartments …

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