Michaël Mekeirele

Use of avacopan in granulomatosis with polyangiitis with predominant gastrointestinal and kidney involvement

Pone De Weerdt, Ward Janssens, Michaël Mekeirele, Tim Balthazar et autres

Avacopan, an oral C5a receptor 1 antagonist, is approved as a glucocorticoid-sparing option for remission induction in antineutrophil cytoplasmic antibody-associated vasculitis. Since April 2026, its marketing authorisation is undergoing regulatory review by the US Food and Drug Administration and the European Medicines …

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Complex Metabolic Acidosis: From Case Report to Systematic Approach

M. Reyskens, Bastiaan Sol, Matthias Raes, Tim Balthazar et autres

A 61‐year‐old woman was admitted with a severe high anion gap metabolic acidosis. Initially, this was attributed to elevated serum lactate levels due to metformin accumulation in the setting of acute kidney injury, and continuous venovenous hemofiltration was started. However, at the …

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The Balance trial: Individualized precision nutrition therapy in critical ill patients treated with continuous venovenous hemofiltration: The impact of indirect calorimetry and bioenergetic balance on energetic need

Daan Gunther Goethals, W. Pieteraerens, L. Buyle, Michaël Mekeirele et autres

BACKGROUND AND AIMS: Personalized precision nutrition therapy is associated with better outcomes but is challenging to achieve. One of the reasons is that indirect calorimetry (IC), the gold standard for measuring the resting energy expenditure (REE), is not yet common practice. Predictive …

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Aggressive Up-Titration of Heart Failure Guideline-Directed Medical Therapies in Cardiogenic Shock Supported by a Percutaneous Ventricular Assist Device

Tim Balthazar, Matthias Raes, Tom Carmeliet, Ines Van Loo et autres

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An unusual case of relapsing arrhythmia during veno-arterial extracorporeal membrane oxygenation cannulation

Ruth Van Lancker, Tim Balthazar, Stijn Lochy, Michaël Mekeirele

Cerebral air embolism can occur in a number of situations. We report two cases of massive cerebral arterial air embolism following cardiopulmonary resuscitation, and its mechanism is discussed.

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Comparison of Bioelectrical Impedance Analysis (BIA)-Derived Parameters in Healthy Volunteers and Critically Ill Patients

Robbert Cleymaet, Marvin D’Hondt, Thomas Scheinok, Luca Malbrain et autres

Objective: To compare bioelectrical impedance analysis (BIA)-derived parameters in healthy volunteers and critically ill patients and to assess its prognostic value in an ICU patient cohort. Design: Retrospective, observational data analysis. Setting: Single centre, tertiary-level ICU (Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg Hospital). …

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Fluid Management in Liver Failure

Michaël Mekeirele, Alexander Wilmer

Abstract In this chapter, fluid management in both acute and acute-on chronic liver failure is discussed. For each pathology, the specific hemodynamic alterations are first described and followed by some general and specific considerations during hemodynamic optimization and evidence-based guidance in the …

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The 4-indications of Fluid Therapy: Resuscitation, Replacement, Maintenance and Nutrition Fluids, and Beyond

Manu L. N. G. Malbrain, Michaël Mekeirele, Matthias Raes, Steven Hendrickx et autres

Abstract The administration of intravenous (IV) fluids in critically ill patients remains a major therapeutic challenge. While there are many questions regarding the type, properties, speed, dose, and timing of fluid administration, there are only four major indications for their use: resuscitation, …

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List of Contributors

Ahsan Ahmed, Tharwat Aisa, Maria Jimena Aleman, Gabriela Alvarado et autres

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Sepsis Treatment: Fluids

Michaël Mekeirele, Domien Vanhonacker, Manu L. N. G. Malbrain

Fluid and Blood Management in Traumatic and Non-traumatic Surgical Emergencies

Domien Vanhonacker, Michaël Mekeirele, Manu L. N. G. Malbrain

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Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts et autres

Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied …

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