A. Rider

Increasing Efficiency, Persistent Burden: Longitudinal Analysis of EHR Use and After-Hours Work in Emergency Medicine Residency

Carl Preiksaitis, Josh Hughes, Mark Iscoe, Michael Makutonin et autres

ABSTRACT Objectives Electronic Health Records (EHRs) impose a significant time burden on physicians, often requiring work to be completed outside of scheduled hours. While this burden is well-documented, how it evolves throughout emergency medicine (EM) residency remains poorly understood. This study aimed …

us (code pays fourni par la source)

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

A. Rider, Henry J. Grantham, Graham R. Smith, David S. Watson et autres

BACKGROUND: Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasis underlie distinct clinical phenotypes and the positive and negative molecular regulators of disease severity across tissue …

gb, it, us (code pays fourni par la source)

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

A. Rider, Henry J. Grantham, Graham R. Smith, David Watson et autres

ABSTRACT Background Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phenotypes and disease severity is poorly defined. Knowledge gaps include whether molecular endotypes of psoriasis underlie distinct clinical phenotypes and the positive and negative molecular regulators of disease severity across …

gb, it, us, nl, fr (code pays fourni par la source)

247 Identification of expression quantitative trait loci with differential effects in the psoriasis transcriptome

A. Rider, Nick Dand, Nick J. Reynolds

gb (code pays fourni par la source)

LB1630 Modular analysis of the psoriasis transcriptome identifies biomarkers of clinical response to distinct classes of biologics and elucidates drug and disease endotypes across skin and blood

A. Rider, Graham R. Smith, D. Watson

gb (code pays fourni par la source)

Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis

Rachel Addison, Sophie Weatherhead, Anandika Pawitri, Graham R. Smith et autres

Ultraviolet B radiation (UVB) exerts pleiotropic effects on human skin. DNA damage response and repair pathways are activated by UVB; if damage cannot be repaired, apoptosis ensues. Although cumulative UVB exposure predisposes to skin cancer, UVB phototherapy is widely used as an …

gb (code pays fourni par la source)

399 Distinct gene expression signatures differentiate clinical response to ustekinumab compared to adalimumab in psoriasis

A. Rider, Graham R. Smith, Amy Foulkes, D. Watson

gb (code pays fourni par la source)