Matthew Chin

Abzu: Uncovering the Origin of Ancient Organics on Mars

Mary Beth Wilhelm, Antonio J. Ricco, Dorothy Z. Oehler, Denise Buckner et autres

I. Ancient Mars is a key target for life-detection missions.Identifying evidence of ancient Martian life would revolutionize our understanding of terrestrial biological processes and predictions for the likelihood of life elsewhere in the Universe.Of all Solar System bodies, Mars must remain a …

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EcAMSat – NASA’s first 6U Biological Spacecraft: System Integration and Environmental Test Technical Paper

Matthew Chin, Stevan Spremo, Timothy V. Snyder, Chris Rogers et autres

The EcAMSat fluidic system to study antibiotic resistance in low earth orbit: Development and lessons learned from space flight

Michael R. Padgen, Tori Chinn, C. Friedericks, Matthew P. Lera et autres

The E. coli AntiMicrobial Satellite (EcAMSat) was a successful spaceflight mission that performed an autonomous experiment to investigate the effects of microgravity on the antibiotic resistance of uropathogenic E. coli; the latest in a series of biology-focused CubeSats developed at NASA Ames …

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EcAMSat spaceflight measurements of the role of σs in antibiotic resistance of stationary phase Escherichia coli in microgravity

Michael R. Padgen, Matthew P. Lera, Macarena Parra, Antonio J. Ricco et autres

, encoded by the rpoS gene, has been shown to increase antibiotic resistance in Earth gravity, but it was unknown if this effect occurs in µ-g. Two strains, wildtype (WT) UPEC and its isogenic ΔrpoS mutant, were grown to stationary phase aboard …

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Microfluidic Approaches to Searching for Extant Life on Mars

R. C. Quinn, Antonio J. Ricco, Travis D. Boone, N. Bramall et autres

EcAMSat: Small Satellite to Examine E. coli's Response in Microgravity to the Antibiotic Gentamicin

Michael R. Padgen, Matthew P. Lera, Macarena Parra, Antonio J. Ricco et autres

We have successfully flown the EcAMSat (Escherichia coli Antimicrobial Satellite) free-flyer mission. This was a 6U small satellite that autonomously conducted an experiment in low Earth orbit to explore the impact of the space environment on antibiotic resistance in uropathogenic E. coli …

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The Search for Life on Icy Worlds: Luminescence Imager for Exploration

R. A. Quinn, Antonio J. Ricco, Matthew Chin, Jonathan Wang et autres

SPLIce: A Microfluidic Sample Processor to Enable the Search for Life on Icy Worlds

Matthew Chin, Antonio J. Ricco, R. C. Quinn, Anthony Lee et autres

Sample Processor for Life on Icy Worlds (SPLIce): Design and Test Results

Tori Chinn, Anthony K. Lee, Travis D. Boone, Ming X. Tan et autres

We report the design, development, and testing of the Sample Processor for Life on Icy Worlds (SPLIce) system, a microfluidic sample processor to enable autonomous detection of signatures of life and measurements of habitability parameters in Ocean Worlds. This monolithic fluid processing-and-handling …

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Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station

Macarena Parra, Jimmy Jung, Travis D. Boone, Luan Tran et autres

The International Space Station (ISS) National Laboratory is dedicated to studying the effects of space on life and physical systems, and to developing new science and technologies for space exploration. A key aspect of achieving these goals is to operate the ISS …

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Payload hardware and experimental protocol development to enable future testing of the effect of space microgravity on the resistance to gentamicin of uropathogenic Escherichia coli and its σs-deficient mutant

A. Matin, J.-H. Wang, M. Keyhan, Rachna Singh et autres

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Payload Hardware and Experimental Protocol for Testing the Effect of Space Microgravity on the Resistance to Gentamicin of Stationary-Phase Uropathogenic Escherichia Coli and Its Sigma (sup S)-Deficient Mutant

Abdul Matin, J.-H. Wang, M. Keyhan, Rachna Singh et autres

Human immune response is compromised and bacteria can become more antibiotic resistant in space microgravity (MG). We report that under low-shear modeled microgravity (LSMMG) stationary-phase uropathogenic Escherichia coli (UPEC) become more resistant to gentamicin (Gm). UPEC causes urinary tract infections (UTIs), reported …

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