Giuseppe Damiano

Skin Photodamage and Melanomagenesis: A Comprehensive Review

Michele Manganelli, Giorgio Stabile, Camila Scharf, Antonio Podo Brunetti et autres

Melanoma, the most aggressive form of skin cancer, still represents a significant and growing public health concern. Ultraviolet radiation (UVR) is considered the primary driver of melanoma, although genetic predisposition also plays a critical role. This review explores the intricate molecular mechanisms …

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Anorectal melanoma: Clinico‐pathological features of a rare and aggressive malignancy in a multicentric study

Giovanni Paolino, Giulio Tosti, Domenico Mascagni, Matteo Riccardo Di Nicola et autres

All data supporting the findings of this study are contained within the main document or the Supporting Information.

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A Viable Human Lung Cancer Tissue Collection (Lctc) to Accelerate Translational Research

Virginia Guzzeloni, A. A. Bartolucci, Samuele Valci, Federica Pedica et autres

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Exploring machine learning tools in a retrospective case-study of patients with metastatic non-small cell lung cancer treated with first-line immunotherapy: A feasibility single-centre experience

Francesca Rita Ogliari, Alberto Traverso, Simone Barbieri, Marco Montagna et autres

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Discovery of 22(S)-23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity

Lorenzo Pontini, Tommaso Angelini, Pietro Palazzoli, Daniela Maggioni et autres

A plethora of studies have demonstrated the crucial role played by Liver X Receptors (LXRs) in cancer. However, whether LXRs activation results in pro-versus anti-tumor effects is still matter of debate. Recently, we have reported the ability of 22(S)-hydroxycholesterol-3-sulfate (PFM037) to antagonize …

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767 Analysis of antitumor immune responses induced by simvastatin plus anti-PD1 in mice and human melanomas

Giuseppe Damiano, Domenico Mallardo, Damiano Cosimo Rigiracciolo, Laura Raccosta et autres

Background Retrospective clinical data on melanoma and non-small cell lung cancers have shown that patients taking statins before the onset of checkpoint inhibitors (CPI), have a better progression free survival (PFS) and overall survival (OS). Starting from this evidence, we investigated the …

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Melanoma in Adolescents and Young Adults (AYAs): An Italian Multi-Centric Retrospective Experience

Mario Valenti, Andrea D’Arino, Enrico Melis, Andrea Carugno et autres

Background: Melanoma is currently the most prevalent malignant neoplasm among adults and represents the second most common cancer in both sexes among individuals aged 0 to 39 years. This retrospective multicenter study delves into the distinctive clinical, anamnestic, histopathologic, and prognostic attributes …

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Predictors of early mortality in patients with wild-type transthyretin cardiac amyloidosis PC73 (#450)

Paolo Milani, Giuseppe Damiano, Roberta Mussinelli, Marco Basset et autres

New reference ranges of free light chain ratio: impact on clinical practice in AL and ATTRwt amyloidosis PB83 (#443)

P. Milani, Martina Ciardo, Marco Basset, Claudia Bellofiore et autres

Proposed hematologic progression criterion in patients with AL amyloidosis OA19 (#475)

Giovanni Palladini, Ute Hegenbart, Paolo Milani, Claudia Bellofiore et autres

A phase II study of daratumumab and pomalidomide in previously treated patients with AL amyloidosis OA10 (#466)

Paolo Milani, Ombretta Annibali, Marco Basset, Martina Ciardo et autres

Long term outcome of a sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis PA166 (#485)

Marco Basset, Paolo Milani, Pietro Benvenuti, Giuseppe Damiano et autres