Hitomi Arahori

Nationwide survey on neonatal resuscitation across delivery facilities in Japan

Hasumi Tomita, Takahiro Sugiura, Hitomi Arahori, Shunsuke Tamaru et autres

BACKGROUND: Neonatal resuscitation is crucial for transitioning to extrauterine life. The Neonatal Cardiopulmonary Resuscitation (NCPR) guidelines in Japan were first developed based on the 2005 International Liaison Committee on Resuscitation (ILCOR) recommendations and have since been revised approximately every 5 years. However, …

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Short-Term Parent Training for Parents of Preterm-Birth Children: A Pilot Two-Arm, Non-Randomized Trial

M Matsui, Haruo Fujino, Hitomi Arahori, Tomoka Yamamoto et autres

Parental mental health is an important outcome for parents of children born preterm. We examined the effects of short-term parent training on parental stress and adaptive functioning in children born preterm. Thirty-one mothers and their children born preterm participated in this study. …

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Isolated congenital diaphragmatic hernia and three-year neurodevelopmental outcomes

Katsuaki Toyoshima, Hirosato Aoki, Kaoru Katsumata, Yoshiaki Sato et autres

BACKGROUND: To retrospectively investigate the developmental outcomes at 3 years of age in patients with congenital diaphragmatic hernia (CDH) using a multicenter collaborative research approach. METHODS: We evaluated patients with CDH and no other malformations born between 2010 and 2016 in seven …

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Mortality and morbidity of extremely low birth weight infants in Japan, 2015

Tokuo Miyazawa, Hitomi Arahori, Satoshi Ohnishi, Hromichi Shoji et autres

BACKGROUND: In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably low in comparison with other developed countries, but the prevalence of chronic lung disease (CLD) and retinopathy of prematurity (ROP) is relatively high. This study aimed to …

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An International Aircraft Transport of a Neonate From Georgia to Japan

Soichiro Saeki, Hidetoshi Taniguchi, Hitomi Arahori, Yasuji Kitabatake et autres

International air transport over long distances necessitates considerable effort. It is even more challenging when the patient is a neonate and has a congenital disease. We hereby report a case of an international aircraft transport of a neonate from Tbilisi, Georgia to …

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Development of information dissemination methods that contribute to improving maternal and child healthcare using social networking sites: a community-based cross-sectional study in Japan

Sayaka Ikeda, Yutaka Ueda, Asami Yagi, Mariko Taniguchi et autres

BACKGROUND: In recent years, feelings of isolation among mothers caring for small children has become a significant social issue in Japan. The purpose of this study is to develop a message to alleviate their loneliness, to evaluate the impact of social networking …

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A questionnaire survey on a feeling of loneliness of the mothers raising children

Asami Yagi, Yutaka Ueda, Mariko Taniguchi, Sayaka Ikeda et autres

AIM: A feeling of isolation childcare mothers' face is a serious social problem in Japan because the relationships with mothers and local communities have grown sparser. The purpose of this study was to clarify the feelings of isolation of mothers during childcare …

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A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

Keiji Kawatani, Toshihiko Nambara, Nobutoshi Nawa, Hidetaka Yoshimatsu et autres

Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remain elusive. …

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The COVID-19 pandemic in Japan: Its impact on a newborn’s childcare environment and on the mother’s sense of loneliness

Ai Miyoshi, Yutaka Ueda, Mariko Taniguchi, Asami Yagi et autres

Abstract Background: The COVID-imposed social isolation of Japanese mothers has significantly increased their already existing sense of loneliness. We report here on the changes that have occurred in the environment of home childcare and in the mother’s feelings of loneliness during the …

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An isogenic cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

Keiji Kawatani, Toshihiko Nambara, Nobutoshi Nawa, Hidetaka Yoshimatsu et autres

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4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

Katsuya Hirata, Toshihiko Nambara, Keiji Kawatani, Nobutoshi Nawa et autres

Individuals with Down syndrome (DS) commonly show unique pathological phenotypes throughout their life span. Besides the specific effects of dosage-sensitive genes on chromosome 21, recent studies have demonstrated that the gain of a chromosome exerts an adverse impact on cell physiology, regardless …

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Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani, Toshihiko Nambara et autres

Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that aneuploidy-associated stress plays an …

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