James P. McRedmond

Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist

Kelly M. Conlon, Joris H. De Maeyer, Chris Bruce, Jan A.J. Schuurkes et autres

Patients with chronic constipation benefit from treatment with 5-hydroxytryptamine 4 (5-HT4) receptor agonists. However, the first-generation 5-HT4 receptor agonists cisapride and tegaserod were withdrawn from the market owing to rare cardiovascular adverse events that were not 5-HT4-receptor-related but due to the lack …

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Differential Expression Of Platelet Proteins In Stable Unstable Coronary Artery Disease and Acute Coronary Syndromes

James P. McRedmond, Brid Holohan, Andrew K. Roy, Rosanna Inzitari et autres

Abstract Background In coronary artery disease (CAD), the risk of platelet-mediated coronary thrombosis varies over time, with the risk of events falling in the months following an episode of acute coronary syndrome (ACS). This study aims to characterize the platelet protein signature …

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Platelet Aggregation Quality Control in a Multicenter, Phase 2 Clinical Trial

James P. McRedmond

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Proteomics of Platelet Granules, Organelles, and Releasate

James P. McRedmond

This chapter contains sections titled: Introduction: Platelet Granules Proteomic Studies of Granules: The Organelle Approach Individual Studies Organelle Separation Clinical Utility of Organelle Proteomics Concluding Remarks Acknowledgment References

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Identification of novel spartin‐interactors shows spartin is a multifunctional protein

Małgorzata Milewska, James P. McRedmond, Paula Catherine Byrne

Hereditary spastic paraplegia describes a group of neurodegenerative diseases characterized by lower limb progressive weakness and spasticity. Troyer syndrome is an autosomal recessive form of hereditary spastic paraplegia caused by a frameshift mutation (1110delA) in the SPG20 gene encoding spartin protein, the …

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High-Throughput Proteomics Detection of Novel Splice Isoforms in Human Platelets

Karen A. Power, James P. McRedmond, Andreas de Stefani, William M. Gallagher et autres

Alternative splicing (AS) is an intrinsic regulatory mechanism of all metazoans. Recent findings suggest that 100% of multiexonic human genes give rise to splice isoforms. AS can be specific to tissue type, environment or developmentally regulated. Splice variants have also been implicated …

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Activity profiling of platelets by chemical proteomics

Jason W.H. Wong, James P. McRedmond, Gerard Cagney

Chemical proteomics or activity based proteomics is a functional proteomics technology where molecular probes are used to target a selective group of functionally related proteins. Its emergence has enabled specific targeting of subproteomes, overcoming the limitations in dynamic range of traditional large-scale …

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A Central Resource for Platelet Proteomics

Gerard Cagney, James P. McRedmond

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Human Proteinpedia enables sharing of human protein data

Suresh Mathivanan, Mukhtar Ahmed, Natalie G. Ahn, Alexandre Hainard et autres

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Genomic and Proteomic Analysis of Platelets

Andrew O Maree, James P. McRedmond

The platelet is a circulating anucleate cell particle created from the cytoplasm of megakaryocytes in the bone marrow from whence it derives much of its cytoplasmic content. Deposited at sites of vascular injury, its role in the processes of thrombosis and haemostasis …

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Finding Drug Targets Through Analysis of the Platelet Transcriptome

James P. McRedmond

Recent studies of the platelet transcriptome have shown it to be complex and readily analysed by modern techniques. Among the thousands of distinct transcripts are many not previously described in platelets. Differences in message abundance between groups are apparent, and these are …

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Integration of Proteomics and Genomics in Platelets

James P. McRedmond, Soon Deok Park, Dermot F. Reilly, Judith A. Coppinger et autres

Platelets, while anucleate, contain RNA, some of which is translated into protein upon activation. Hypothesising that the platelet proteome is reflected in the transcriptome, we identified 82 proteins secreted from activated platelets and compared these, as well as published proteomic data, to …

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