Peter Akpunonu

Intravenous Followed by Oral Varespladib as Late Adjunctive Therapy for Snakebite: a Phase II Randomized Clinical Trial

Charles J. Gerardo, Bhalla Ak, Chitta Ranjan Mohanty, Badal Kumar Sahu et autres

Background Snakebite envenoming causes an estimated 138,000 deaths and more than 400,000 cases of permanent disability each year, disproportionately affecting low-resource regions. Antivenom is the only treatment but requires intravenous administration. We evaluated intravenous followed by oral varespladib as adjunctive therapy to …

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Cardiovascular Complications of Seasonal Influenza in the Pre- and Post-COVID-19 Era: Epidemiology, Mechanisms, and Clinical Implications

Chikodili Nebuwa, Chukwudi Kingsley Orjichukwu, Rita Ogochukwu Orjichukwu, Peter Akpunonu et autres

Influenza has long been a well-documented contributor to cardiovascular morbidity and mortality, particularly among high-risk groups. COVID-19 has notably altered the seasonality and natural history of pandemic influenza, with broad implications for related cardiac complications. This review examines the interaction between influenza …

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Microbiome and Heart Failure: A Comprehensive Review of Gut Health and Microbiota-Derived Metabolites in Heart Failure Progression

Chukwudi Kingsley Orjichukwu, Rita Ogochukwu Orjichukwu, Peter Akpunonu, P.C. Okechukwu Ugwu et autres

A multifaceted clinical disease, heart failure (HF) is typified by decreased cardiac function and systemic symptoms caused by anatomical or functional abnormalities in the heart. Although traditional studies have concentrated on hemodynamic and neurohormonal processes, new data highlight the vital role that …

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Once, twice, three times a bite victim: recidivism in snake envenomation

Spencer Greene, Amber Anderson, George Warpinski, Sharan Campleman et autres

INTRODUCTION: We believe there are certain behaviors that may predispose people to being bitten by a snake. The purpose of this study was to describe cases reported to the North American Snakebite Registry in which the snakebite victim acknowledged multiple lifetime snakebites …

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Large Language Models for Drug Overdose Prediction from Longitudinal Medical Records

Md Sultan Al Nahian, Chris Delcher, Daniel R. Harris, Peter Akpunonu et autres

The ability to predict drug overdose risk from a patient's medical records is crucial for timely intervention and prevention. Traditional machine learning models have shown promise in analyzing longitudinal medical records for this task. However, recent advancements in large language models (LLMs) …

Methodology for Single- vs Polydrug Classification of Poisoning Deaths

Svetla Slavova, Douglas R. Oyler, Sarah Hargrove, Holly Hedegaard et autres

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Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial

Charles J. Gerardo, Rebecca W. Carter, Surendra Kumar, Farshad M. Shirazi et autres

INTRODUCTION: Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a nearly ubiquitous component of snake venoms. We conducted a phase II clinical trial to assess efficacy and …

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The American College of Medical Toxicology (ACMT) Commitment to Diversity, Equity, and Inclusion in Medical Toxicology

Peter Akpunonu, Richard J. Church, Kavita M. Babu, Trevonne M. Thompson

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Using natural language processing to identify opioid use disorder in electronic health record data

Peter Akpunonu, Erin L. Abner, Anna Kucharska‐Newton, James A. Singleton et autres

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Association of Nonacute opioid use and cardiovascular diseases: A scoping review of the literature

Anna Kucharska‐Newton, Jade Singleton, Erin L. Abner, Peter Akpunonu

BACKGROUND: In this scoping review, we identified and reviewed 23 original articles from the PubMed database that investigated the relationship between nonacute opioid use (NOU) and cardiovascular outcomes. METHODS AND RESULTS: We defined NOU to include both long-ŧerm opioid therapy and opioid …

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Oral Varespladib for the Treatment of Snakebite Envenoming in India and the United States (BRAVO): A Phase 2 Randomised Clinical Trial

Charles J. Gerardo, Rebecca W. Carter, Surendra Kumar, Farshad M. Shirazi et autres

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4 Oral Varespladib for Snakebite Envenoming: The BRAVO International Randomized Controlled Trial

Charles J. Gerardo, Timothy F. Platts‐Mills, S. Samuel, Santosh Kumar et autres