Yaqi Liu

Single-cell RNA sequencing and spatial transcriptomics reveal heterogeneity and key subgroups in ovarian cancer: HOXA1 identified as a potential therapeutic biomarker

Zhiheng Lin, Yaqi Liu, Wangzheqi Zhang, Qian Zhao et autres

BACKGROUND: Ovarian cancer (OC), as one of the gynecological malignancies, seriously threatens people's life, health and safety with its high recurrence rate and high mortality rate. METHODS: The GEO database served as the source of Single-cell RNA sequencing (scRNA-seq) data used in …

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Programmed cell death in triple-negative breast cancer

Yaqi Liu, Jin‐Wei He, Jialu Chen, Tianhui Chen et autres

Triple-negative breast cancer (TNBC) is a particularly aggressive and therapeutically challenging subtype of breast cancer, defined by the lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This absence of actionable molecular targets contributes to its resistance …

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Metformin sensitizes non-small cell lung cancer to CDK4/6 inhibitor treatment by reducing lysosomal trapping

Yaqi Liu, Yalei Wang, Ni Zhang, Hailin Xiong et autres

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Abstract 415: Metformin sensitizes non-small cell lung cancer to CDK4/6 inhibitor treatment by reducing lysosomal trapping

Yaqi Liu, Yalei Wang, Ni Zhang, Hailin Xiong et autres

Abstract Hyperactivation of cyclin D1-CDK4/6 signaling is correlated with tumour metastasis, and poor prognosis in patients with non-small cell lung cancer (NSCLC), suggesting the therapeutical potential of targeting CDK4/6 to treat NSCLC. Our preliminary data suggest CDK4/6 inhibitors are sequestered in lysosomes …

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Stanniocalcin 2 governs cancer cell adaptation to nutrient insufficiency through alleviation of oxidative stress

Shuo Qie, Hailin Xiong, Yaqi Liu, Chenhui Yan et autres

Solid tumours often endure nutrient insufficiency during progression. How tumour cells adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified STC2 as one of the most upregulated genes in cells exposed to nutrient insufficiency by transcriptome screening, indicating the …

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Stanniocalcin 2 governs cancer cell adaptation to nutrient insufficiency through alleviation of oxidative stress

Shuo Qie, Hailin Xiong, Yaqi Liu, Chenhui Yan et autres

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Bioinformatic Analysis of The Prognostic Value of A Panel of Six Amino Acid Transporters in Human Cancers.

Yaqi Liu, Hailin Xiong, Chenhui Yan, Yalei Wang et autres

OBJECTIVE: Solid tumor cells utilize amino acid transporters (AATs) to increase amino acid uptake in response to nutrient-insufficiency. The upregulation of AATs is therefore critical for tumor development and progression. This study identifies the upregulated AATs under amino acid deprived conditions, and …

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LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer.

Yi‐Qiang Cheng, H-Y Xiong, YM Li, H-R Zuo et autres

OBJECTIVE: Long noncoding RNA (lncRNA) was found to play crucial roles in regulating cancer progression. HOXA11 antisense RNA (HOXA11-AS) was reported to serve an oncogenic lncRNA in cancers but its role in prostate cancer (PCa) remains to be explored. MATERIALS AND METHODS: …

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