Gabriela S. Silva Santos

Mechanisms of antibody-mediated enhancement of immune responses

Melissa Cipolla, Andrew J. MacLean, Brianna Hernandez, Gabriela S. Silva Santos et autres

Immune memory responses are rapid and qualitatively distinct from primary responses. They typically develop in the presence of antigen-experienced memory T and B cells and preexisting antibodies. Although the contribution of T and B cells to recall responses is well defined, the …

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Antibody-mediated diversification of primary and secondary humoral immune responses

Dennis Schaefer-Babajew, L Binet, Gabriela S. Silva Santos, Chiara Ruprecht et autres

Humoral immune responses are characterized by increasing antibody affinity and diversity over time. Increased affinity is mediated by a combination of immunoglobulin gene somatic mutation and iterative cycles of selection in germinal centers. Less is understood about how diversity increases. Here, we …

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Fc receptor dependent and independent mechanisms of antibody-mediated enhancement of immune responses

Melissa Cipolla, Andrew J. MacLean, Brianna Hernandez, Gabriela S. Silva Santos et autres

Abstract Immune memory responses are rapid and qualitatively distinct from primary responses. They typically develop in the presence of antigen-experienced memory T and B cells and pre-existing antibodies. Although the contribution of T and B cells to recall responses is well defined, …

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Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice

Marie Wiatr, zijun wang, Marie Canis, Brianna Hernandez et autres

Nanoparticle immunogens excel at rapidly inducing high levels of circulating antibodies and are being deployed as part of several novel vaccines. However, their ability to elicit memory B cell responses is less well understood. Here, we compared serologic and memory B cell …

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Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

Dennis Schaefer-Babajew, L Binet, Gabriela S. Silva Santos, Lachlan P. Deimel et autres

Abstract Humoral immune responses are characterized by increasing antibody affinity and diversity over time. Increased affinity is mediated by a combination of immunoglobulin gene somatic mutation and iterative cycles of selection in germinal centers. Less is understood about how diversity increases. Here …

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Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones

Cíntia Bittar, Ana Rafaela Teixeira, Thiago Y. Oliveira, Gabriela S. Silva Santos et autres

Antiretroviral therapy suppresses HIV-1 infection but fails to eliminate a reservoir of intact latent proviruses that reside primarily in CD4+ T cells. The lack of precise understanding of the latent compartment has made it challenging to develop curative strategies for HIV-1 infection. …

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HIV-1 expression is heterogeneous among clones of CD4+ T cells carrying authentic intact latent proviruses

Cíntia Bittar, Ana Rafaela Teixeira, Thiago Y. Oliveira, Gabriela S. Silva Santos et autres

Abstract Antiretroviral therapy suppresses HIV-1 infection but is not curative because it fails to eliminate a reservoir of intact latent proviruses that reside primarily in CD4+ T cells. This compartment is composed of rare T cells that predominantly express memory and effector …

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Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates

Lachlan P. Deimel, Yoshiaki Nishimura, Gabriela S. Silva Santos, Viren A. Baharani et autres

Effective vaccines elicit B cell clonal expansion in germinal centers (GCs) that produce memory B cells and antibody-secreting plasma cells. In mice, memory B cells rarely re-enter GCs upon boosting and instead differentiate into plasma cells. However, mouse circulating memory constitutes only …

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Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

Lachlan P. Deimel, Yoshiaki Nishimura, Gabriela S. Silva Santos, Viren A. Baharani et autres

Summary Effective vaccines elicit B cell clonal expansion in germinal centers (GCs) that produce memory B cells and antibody secreting plasma cells. Studies in mice indicate that, whereas the plasma cell compartment is enriched for cells producing high affinity antibodies, the memory …

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Correction: Transcription of HIV-1 at sites of intact latent provirus integration

Ana Rafaela Teixeira, Cíntia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira et autres

Upon further analysis after publication, the authors found that the HIV integration site for clone 5104 is in the satellite region of chromosome 22 (chr22:10,229,326-10,229,469) and not in the intron of the ATP2B4 gene as stated in the original version of the …

Regulated somatic hypermutation enhances antibody affinity maturation

Julia Merkenschlager, Andrew G. T. Pyo, Gabriela S. Silva Santos, Dennis Schaefer-Babajew et autres

Abstract Germinal centres are specialized microenvironments where B cells undergo affinity maturation. B cells expressing antibodies whose affinity is improved by somatic hypermutation are selected for expansion by limiting numbers of T follicular helper cells. Cell division is accompanied by mutation of …

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Affinity maturation of antibody responses is mediated by differential plasma cell proliferation

Andrew J. MacLean, Lachlan P. Deimel, Pengcheng Zhou, Mohamed ElTanbouly et autres

Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, is selected into the …

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