G Corte

Missing Opportunity for Nephroprotective Therapy in Patients With Non-Dialysis CKD Under Stable Nephrology Care

Luca De Nicola, Chiara Ruotolo, Gaetano La Manna, Vincenzo Bellizzi et autres

Introduction: Awareness of the implementation of guideline-directed nephroprotective therapy is an essential preliminary step to optimize implementation of nephroprotective strategies in nondialysis chronic kidney disease (CKD) (ND-CKD). However, updated information on this issue is lacking in the setting of nephrology clinics. Methods: …

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ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

G Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz et autres

The inhibitor of DNA-binding 3 (ID3) plays a crucial role in DNA double-strand break (DSB) repair. We previously reported that ID3 loss reduced chromatin accessibility at DNA repair gene promoters, yet its exact role in DNA repair via chromatin regulation remains elusive. …

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ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response

Ali Bakr, G Corte, Olivera Veselinov, Simge Kelekçi et autres

AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA repair defects. Here, we show that ARID1A plays epigenetic roles to promote both DNA double-strand breaks (DSBs) …

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An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease

Paolo Giannoni, Silvia Scaglione, Rodolfo Quarto, Roberto Narcisi et autres

BACKGROUND: Chronic lymphocytic leukemia cells are characterized by an apparent longevity in vivo which is lost when they are cultured in vitro. Cellular interactions and factors provided by the microenvironment appear essential to cell survival and may protect leukemic cells from the …

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Gefitinib Targets EGFR Dimerization and ERK1/2 Phosphorylation to Inhibit Pleural Mesothelioma Cell Proliferation

Roberto E. Favoni, Alessandra Pattarozzi, Martina Lo Casto, Federica Barbieri et autres

Altered EGFR activity is a causal factor for human tumor development, including malignant pleural mesotheliomas. The aim of the present study was the evaluation of the effects of Gefitinib on EGF-induced mesothelioma cell proliferation and the intracellular mechanisms involved. Cell proliferation, DNA …

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[P2.31]: A Dlx5–Wnt5 regulation involved in the control of GABAergic differentiation

Giorgio R. Merlo, S. Paina, Alessia Moiana, Elena Cattaneo et autres

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The sea urchin, Paracentrotus lividus, embryo as a “bioethical” model for neurodevelopmental toxicity testing

Maria Grazia Aluigi, C. Angelini, G Corte, Carla Falugi

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Six3 Controls the Neural Progenitor Status in the Murine CNS

Irene Appolloni, Filippo Calzolari, G Corte, Roberto Perris et autres

Six3, a homeodomain-containing transcriptional regulator belonging to the Six/so family, shows a defined spatiotemporal expression pattern in the developing murine telencephalon, suggesting that it may control the development of specific subsets of neural progenitors. We find that retrovirus-mediated misexpression of Six3 causes …

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Disruption of the murine PIASx gene results in reduced testis weight

Henrikki Santti, Laura Mikkonen, Ashish Anand, Sirpa J Hirvonen-Santti et autres

PIASx belongs to the PIAS protein family, the members of which modulate activities of several transcription factors and act as E3 ligases in the sumoylation pathway. The PIASx gene is highly expressed in testis, suggesting a role in spermatogenesis. To investigate the …

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Enhanced engraftment of EPO-transduced human bone marrow stromal cells transplanted in a 3D matrix in non-conditioned NOD/SCID mice

Antonio Daga, Anita Muraglia, Rodolfo Quarto, Ranieri Cancedda et autres

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Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue

Janet J. Bijl, JW van Oostveen, Marja Kreike, Elizabeth Rieger et autres

Besides their regulatory role in embryogenesis, homeobox (HOX) genes are expressed in a specific manner in hematopoietic cell lineages, implying a role in the molecular regulation of hematopoiesis. Some HOX C cluster genes are found to be expressed in lymphoid cells of …

Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue

Janet J. Bijl, JW van Oostveen, Marja Kreike, Elizabeth Rieger et autres

Besides their regulatory role in embryogenesis, homeobox (HOX) genes are expressed in a specific manner in hematopoietic cell lineages, implying a role in the molecular regulation of hematopoiesis. Some HOX C cluster genes are found to be expressed in lymphoid cells of …