Byeong‐Cheol Ahn

One Ligand, Two Messages: How JAG2 Reconciles Self-Renewal and Differentiation in Muscle Stem Cells

Janitri Venkatachala Babu, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran et autres

us, in, kr (code pays fourni par la source)

Nucleolin overexpression correlates with poor prognosis and immune checkpoint regulation across various cancer types: Insights from The Cancer Genome Atlas and GTEx analyses

Kruthika Prakash, Janani Balaji, Surya Babu, Ramya Lakshmi Rajendran et autres

Introduction: Nucleolin (NCL) is an established cancer target proposed to modulate the tumor immune microenvironment, but has not been systematically tested across cancers. Objective: To systematically investigate the pan-cancer association of NCL expression with tumor progression, prognosis, and the tumor immune microenvironment, …

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Macrophage polarization-mediated remodeling of the tumor immune microenvironment regulates NIS expression in thyroid cancer cells

Byeong‐Cheol Ahn, Liya Zhu

Artificial Intelligence-Enabled Exosomes in Precision Oncology: A Framework for Clinical Utility and Biomedical Applications

Prakash Gangadaran, Ramya Lakshmi Rajendran, Muthu Subash Kavitha, Byeong‐Cheol Ahn

Exosomes are 30-150 nm extracellular vesicles that convey molecular information reflecting the physiological and pathological states of their source cells. In precision oncology, they function as a non-invasive "liquid biopsy," enabling real-time monitoring of tumor dynamics and metastasis. However, extreme biofluid heterogeneity …

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Dnmt3L Acetylation as a Post-Translational Switch Linking Extracellular Environment to Epigenetic Stability in Pluripotent Stem Cells

Janitri Venkatachala Babu, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran et autres

us, in, kr (code pays fourni par la source)

A review on tyrosine kinase inhibitors for targeted breast cancer therapy

Vidya Sankarapandian, Ramya Lakshmi Rajendran, Conrad Ondieki Miruka, Poornima Sivamani et autres

Breast cancer is a heterogeneous disease with complex molecular pathogenesis. Overexpression of several tyrosine kinase receptors is associated with poor prognosis, therefore, they can be key targets in breast cancer therapy. Tyrosine kinase inhibitors (TKIs) have emerged as leading agents in targeted …

A review on tyrosine kinase inhibitors for targeted breast cancer therapy

Vidya Sankarapandian, Ramya Lakshmi Rajendran, Conrad Ondieki Miruka, Poornima Sivamani et autres

Breast cancer is a heterogeneous disease with complex molecular pathogenesis. Overexpression of several tyrosine kinase receptors is associated with poor prognosis, therefore, they can be key targets in breast cancer therapy. Tyrosine kinase inhibitors (TKIs) have emerged as leading agents in targeted …

Therapeutic Potential of Peptides in Cancer Treatment: Focus on Peptide and Aptamer-Decorated Exosomes

Prakash Gangadaran, Aswini Suresh Kumar, K Kumaran, Kruthika Prakash et autres

Traditional cancer therapies such as surgery, chemotherapy, and antibody-based treatments often face significant barriers, including systemic toxicity, a lack of selectivity, and the emergence of drug resistance. These issues demand innovative and targeted solutions. Peptide-based therapeutics have gained prominence for their ability …

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Reigniting the Flame for Redifferentiation Strategies in Differentiated Thyroid Cancers: Journey of Tyrosine Kinase Inhibitors to Renewed Radioactive-Iodine Avidity

Ji Min Oh, Liya Zhu, Byeong‐Cheol Ahn

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Tumoroid-derived extracellular vesicles for prognosis and therapeutics: A valuable tool in precision medicine

Vijay Murali Ravi Mythili, Vasanth Kanth Loganathbabu Thasma, Shriya Pattabiram, Kumaran Kasinathan et autres

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Exosomal delivery of GrpE-like 1 from synovial mesenchymal stem cells activates PINK1-mediated mitophagy for cartilage repair in osteoarthritis

Soumya Deep Phadikar, Ramya Lakshmi Rajendran, Sathish Muthu, Prakash Gangadaran et autres

GrpE-like 1 (GRPEL1)-carrying exosomes derived from synovial mesenchymal stem cells (SMSC) prevent mitochondrial dysfunction associated with osteoarthritis (OA) by activating PINK1-mediated mitophagy, restoring chondrocyte function, and preserving the extracellular matrix both in vitro and in vivo . Bioinformatics analysis of human OA …

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Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers

Madhan Jeyaraman, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Swaminathan Ramasubramanian et autres

in, mx, kr (code pays fourni par la source)