Sahar S. Alghamdi

Nanoparticle-Enabled Biomaterials for Controlled Drug Delivery in Implantable and Wearable Devices

Zahrah Asiri, Abeer Mobarki, Sahar S. Alghamdi, Abdulaziz A. Almoutairi et autres

Conventional oral and injectable drug administration still struggles with unstable plasma levels, weak targeting, and considerable systemic toxicity, problems that become especially acute in chronic disease management. Implantable and wearable biomedical devices offer one path around these limits, yet device-only platforms continue …

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Artificial Intelligence in Selected Domains of Drug Discovery: A Critical Narrative Review

Marwah I Bin Abdulqader, Abdulrhman A Alsaqabi, Afrah E. Mohammed, Sahar S. Alghamdi

Introduction: Traditional drug discovery is historically characterized by high attrition rates, escalating financial costs, and decades-long development timelines. As global health challenges-particularly antimicrobial resistance and complex malignancies-intensify, the urgent need for innovative and accelerated therapeutic solutions has never been more critical. Artificial …

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Gazania rigens (L.) gaertn leaf extract-inspired innovative synthesis of silver nanoparticles and promising applications as antibacterial and cytotoxic agents

Afrah E. Mohammed, Reham M. Aldahasi, Hessa O. Aldraiwiesh, Ishrat Rahman et autres

Introduction: Silver nanoparticles are potent nanomaterials with significant applications in combating microbial infections and cancer. In this study, the extract of Gazania rigens var. uniflora was evaluated as a biogenic agent for the synthesis (G-AgNPs), and their biological activity was systematically assessed. …

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Quinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications

Jinan Alhuwayshil, Nouf Alnajim, Sarah bin Dulaym, Jehan Barakat Alamre et autres

Cancer continues to be a leading cause of morbidity and mortality globally, which necessitates the development of more effective and less toxic therapies. Quinoxaline derivatives, a class of heterocyclic compounds with versatile chemical structures, have emerged as promising candidates for anticancer drug …

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EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approach

Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Muhammad Nawaz et autres

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Efficacy of a bioflavonoid-enriched herbal versus 0.12% and 0.2% chlorhexidine mouthwashes in reducing peri-implant inflammation and subgingival Porphyromonas gingivalis carriage in patients with peri-implantitis

Nujud Alamry, Danah E. Aloumi, Sahar S. Alghamdi, Afrah E. Mohammed et autres

BACKGROUND: This study compared the efficacy of a bioflavonoid-enriched herbal mouthwash versus 0.12% and 0.2% chlorhexidine (CHX) in reducing peri-implant inflammation and subgingival Porphyromonas gingivalis (P. gingivalis) carriage among patients with peri-implantitis. METHODS: In all, 67 individuals diagnosed with peri-implantitis were enrolled. …

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Deciphering molecular pathways driving cancer invasion and metastasis: advances and therapeutic prospects

Aziza Alshahrani, Arwa Alsubait, Zahrah Ali Ahmed Asiri, Sahar S. Alghamdi et autres

Metastasis is the primary cause of cancer-related mortality worldwide. This narrative review integrates recent advances in the molecular circuits orchestrating metastatic progression, encompassing epithelial-mesenchymal transition (EMT), organotropism, extracellular matrix remodeling, angiogenesis, hypoxia-inducible signaling, tumor-cell migration modes, and tumor-immune interactions through expert-guided literature …

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Emerging topical therapies for melasma: a comparative analysis of efficacy and safety

Rasha Saad Suliman, Jinan Alhuwayshil, Amal Ahmed Almuflehi, Aya Khaldoon Al Zaghir et autres

PURPOSE: Melasma, a prevalent acquired hypermelanosis, significantly impacts psychological well-being. It presents as irregular, bilateral patches of brown or gray skin discoloration and currently lacks a curative treatment. Management focuses on controlling disease progression and preventing further hyperpigmentation through photoprotection, topical and …

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Targeting triple-negative breast cancer: apoptotic and antitumor effects of Artemisia sieberi Besser extracts

Fatimah Gh. Albani, Sahar S. Alghamdi, Sabine Matou‐Nasri, Arwa Alsubait et autres

Artemisia sieberi Besser (A. sieberi) has shown promise as a natural source of safe cytotoxic agents for breast cancer therapy. However, its effects on triple-negative breast cancer (TNBC), a very aggressive subtype lacking targeted treatments, remain poorly studied. This study evaluates the …

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Metabolite detection via QTOF-LCMS and computational analysis on Russelia equisetiformis exploring green nanotechnology and antifungal against phytopathogens

Reham M. Aldahasi, Sahar S. Alghamdi, Nouf Albulushi, Hanin Alhuraibi et autres

This study explores Russelia equisetiformis as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (N-CDs), and their nanocomposite (MnO …

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Transforming Pain Management: Suzetrigine, a Novel Non-Opioid Analgesic

Maha AlDoughaim, Nada Alsuhebany, Mohammed Alzahrani, Atheer Aldairem et autres

Suzetrigine is a novel non-opioid analgesic that selectively inhibits the Nav1.8 sodium channel, which plays a key role in peripheral pain signaling. By blocking action potential propagation in nociceptors, it effectively reduces pain without affecting the central nervous system, thus avoiding the …

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Reticuline and Coclaurine Exhibit Vitamin D Receptor-Dependent Anticancer and Pro-Apoptotic Activities in the Colorectal Cancer Cell Line HCT116

Sahar S. Alghamdi, Maryam H. Al-Zahrani, Thadeo Trivilegio, Sara Bahattab et autres

Alkaloids have garnered significant interest as potential anticancer agents. Vitamin D receptor (VDR) plays a role in preventing the progression of colorectal cancer (CRC) and may be a crucial mediator of the anticancer effects produced by certain alkaloids. The search for novel …

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