John A. Browne

Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle

Gillian P. McHugo, James A. Ward, Said I. Ng’ang’a, Laurent Frantz et autres

ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic …

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Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming

Thomas J. Hall, Morgane Mitermite, John F. O’Grady, John A. Browne et autres

Abstract Background Bovine tuberculosis (bTB) is a chronic infectious disease primarily caused by Mycobacterium bovis , which inflicts significant economic losses on the global livestock industry worldwide and can also cause tuberculosis (TB) disease in other mammalian species, including humans. Alveolar macrophages …

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Leptospira interrogans serovar Copenhageni infection and exudative glomerulonephritis in rehabilitated gray seals (Halichoerus grypus) and harbor seals (Phoca vitulina) in Ireland

Michelle Imlau, Tristan Russel, John A. Browne, Ruth A. O’Connell et autres

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A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

John F. O’Grady, Adriana Ivich, Gillian P. McHugo, Adnan Khan et autres

Abstract Bovine tuberculosis (bTB) remains recalcitrant to eradication in many endemic countries where current diagnostics are suboptimal. Mycobacterium bovis causes bTB and is closely related to Mycobacterium tuberculosis , which causes human tuberculosis (hTB). Although blood-based mRNA biomarkers identified through machine learning …

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Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues

Gillian P. McHugo, James A. Ward, John A. Browne, Grace M. O’Gorman et autres

Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease caused by infection with trypanosome parasites (Trypanosoma spp.). These are transmitted by infected tsetse flies (Glossina spp.) and cause a similar disease in animals, known as African animal trypanosomosis (AAT), …

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Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rate in stabled riding school horses (Equus caballus)

Linda Greening, Eilís E. Harkin, Panoraia Kyriazopoulou, Zoe Heppelthwaite et autres

Modern horse husbandry involves significant time spent indoors, often in suboptimal lighting conditions and with frequent night-time disturbances by humans for management purposes. The aim of this study was to investigate the influence of a customised light-emitting diode (LED) lighting system and …

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Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rates in stabled riding school horses (Equus caballus)

Linda Greening, Eilís E. Harkin, Panoraia Kyriazopoulou, Z. Hepplethwaite et autres

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Correction: Transcriptomics analysis of the bovine endometrium during the perioestrus period

Mohammed A. Alfattah, Carolina N. Correia, John A. Browne, Paul McGettigan et autres

Function and Behavior, with links to voltage-dependent Na+ channels and SYN genes, encoding synapsins that are associated with the trafficking of synaptic vesicles."

Surveillance for Leptospira sp. in Native and Invasive Shrews in Ireland Compared with Cohabitating Shrews in France

Michelle Imlau, John A. Browne, Samuel S. Browett, Allan D. McDevitt et autres

Leptospirosis is a complex and often underestimated global bacterial disease that continues to be of zoonotic concern. It is difficult to diagnose and has an unclear pathogenesis. Several new species of the genus Leptospira have been discovered in recent years; the impact …

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Specificity protein 1 (SP1) plays an essential role in early bovine embryo development

Anup Kumar Talukder, A. Al Naib, Solomon Mamo, Laura L. Thompson et autres

A previous RNA-Seq study revealed that the transcript abundance of specificity protein 1 (SP1) was significantly higher in Day 7 bovine blastocysts compared to conceptuses on Days 10, 13, 16, and 19, suggesting a stage-specific role in early bovine embryo development. The …

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Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues

Gillian P. McHugo, James A. Ward, John A. Browne, Grace M. O’Gorman et autres

Abstract Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease caused by infection with trypanosome parasites ( Trypanosoma spp.). These are transmitted by infected tsetse flies ( Glossina spp.) and cause a similar disease in animals, known as African …

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TP62 - Rapid and Sensitive MiRNA Detection in Biofluids Using Ultra Microelectrode Sensors.

Mariana Valente, M. A. Ridwan, Alan O’Riordan, Jorge Marques et autres

MiRNA are short nucleic acids sequences that are correlated to many important genetic cascades response, immune response being among one of the most important.Our previous sensors, able to detect DNA, is now used not only to detect miRNA sequences in plasma but …

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