Shaowen Tang

Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy

Jiaying Hu, Shijiu Lu, Lianju Qin, Yaoting Sun et autres

Calciphylaxis (calcific uremic arteriolopathy, CUA) is a rare, fatal disorder primarily affecting chronic kidney disease patients, characterized by microvascular calcification, thrombosis, and skin necrosis. In a discovery cohort (3 CUA, 10 uremic), plasma proteomics identified Thrombospondin-1 (THBS1) as the top upregulated hub …

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Post-Marketing Active Surveillance of Adverse Events Following Quadrivalent Subunit Influenza Vaccine in Healthy Participants Aged ≥ 3 Years in China

Mingwei Wei, Yu Pan, K J Wang, Ming Li et autres

INTRODUCTION: The observational phase IV study through an active surveillance system aimed to assess the safety of the subunit influenza vaccine in healthy individuals aged ≥ 3 years and explore the feasibility of using an active adverse event (AE) surveillance system based …

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Association of albumin-bilirubin grade with prognosis in ICU patients with pulmonary edema: a retrospective cohort study and a predictive model based on machine learning

Chang You, Yingqi Yang, Ziyan Zhao, Jiahao Wang et autres

BACKGROUND: The Albumin-Bilirubin (ALBI) grade was initially used to assess liver reserve function in patients with cirrhosis and has since been applied in the prognostic evaluation of various diseases. This study explored the relationship between the ALBI grade and the prognosis of …

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Construction and Validation of a Predictive Model for the Risk of Anti‐Tuberculosis Drug‐Induced Liver Injury Based on Machine Learning Algorithms

Jing-Ru C. Cheng, Ruina Chen, Hongqiu Pan, Lihuan Lu et autres

Anti-tuberculosis drug-induced liver injury (ATLI) is the most harmful to anti-tuberculosis (TB) treatment. This study aims to construct and validate a binary ATLI risk prediction model based on clinical data through seven machine learning algorithms (logistic regression, decision tree, support vector machine, …

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No interaction between genetic variants and DNA methylation of the ferrochelatase gene in relation to antituberculosis drug-induced liver injury

Fei Wang, Meiling Zhang, Yu Wu, Jing-Ru C. Cheng et autres

OBJECTIVE: The pathogenic mechanisms of antituberculosis drug-induced liver injury (AT-DILI) remain unclear. Isoniazid and rifampicin may lead to hepatic accumulation of protoporphyrin IX in which heme synthesis ferrochelatase (FECH), a key rate-limiting enzyme, potentially plays an important role. This study aimed to …

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Whole exome sequencing identifies rare variants involved in PPIX-metabolizing pathway in anti-TB drug-induced hepatitis

Yu Wu, Lihuan Lu, Fei Wang, Mei‐Ling Zhang et autres

Aims To screen and validate rare variants in the protoporphyrin IX (PPIX)-metabolizing pathway associated with anti-tuberculosis drug-induced hepatitis (AT-DIH).Methods A two-stage matched case-control study was conducted. Firstly, a 1:1 matching design (50 cases and 50 controls) was adopted to screen for rare …

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EP.12.03 Study on the Effects of Anlotinib Combined with PD-1 Antibody in Lung Cancer Rats and Its Impact on the PLGF/Flt-1 and TGF-ß1 Pathways

Shaowen Tang, Tao Zhang, J. Zhang

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Safety, tolerability, and pharmacokinetic characteristics of a sustained-release formulation of ropivacaine (QP-6211) in healthy Chinese participants: a dose-escalation phase I clinical trial

Lichun Dong, Yan Jiang, Jianjun Chen, Quan Wang et autres

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Development of a risk prediction model for Alzheimer's disease based on the UK Biobank prospective study

Huilin Li, Yiwen Wu, Ting Huang, Yue Sun et autres

BackgroundEarly prevention and intervention for Alzheimer's disease (AD) are critical due to the absence of effective therapeutic treatment. However, a widely accepted risk prediction model for AD has yet to be established.ObjectiveTo develop a novel risk prediction model for AD by leveraging …

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Integration of Multi-omics Data Based on Deep Learning for Subtyping of Low-Grade Glioma

Huilin Li, Mingdong Li, Yue Sun, Eileen Hao Yu et autres

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HOPX regulates the invasion and migration abilities of hepatocellular carcinoma by targeting SNAIL

Rong Wang, Haizhou Xu, Cheng‐Hu Hu, Kun Chen et autres

HOPX acts as a tumor suppressor in certain cancers, but the function of HOPX, as well as its mechanism of action in hepatocellular carcinoma (HCC) has not been fully elucidated. In this study, using in vitro and in vivo animal models, the …

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An Efficient Local-Global Fusion Framework for Accurate Vascular Segmentation

Huiyin Xu, Sheng Cao, Shuxiang Guo, Chong Yang et autres

Accurate vascular segmentation is crucial for assisting interventional surgical robots by providing detailed anatomical information for navigation and treatment planning. However, the complex topology of vascular structures and the demand for real-time performance pose significant challenges, especially in clinical environments with limited …

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