Madina Ramazanova

Integrated Chemical and Biological Profiling of Selected Wild Allium Species from Kyrgyz Alatau

Nadezhda Gemejiyeva, Dinara Myrzabekova, Raya Arysbaeva, Madina Ramazanova et autres

Wild Allium L. species are important sources of mineral elements and structurally diverse primary and specialized metabolites, yet comparative information integrating their elemental composition, lipophilic constituents, polar metabolites, and biological activity remains limited. This study compared the chemical diversity of four wild …

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Comprehensive Phytochemical Profiling of Iris songarica Rhizomes and Evaluation of Their Anti-Inflammatory Activity In Vivo

Madina Ramazanova, Alfira F. Miftakhova, Zhanat Karzhaubekova, Diana Issa et autres

The chemical composition of Iris songarica rhizome extracts was systematically investigated using GC-MS and UHPLC-MS. Their biological activity was further evaluated in vivo. The chloroform rhizome extract contained 33 identified compounds distributed across five main classes. Flavonoids predominated (50.7% of total ionic …

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Phytochemical Analysis, Mineral Composition and GC-MS Profiling of Three Iris Species from the Southeastern Part of Kazakhstan

Madina Ramazanova, Zhanat Karzhaubekova, Nadezhda Gemejiyeva, Konstantin Andreevich Krasnov et autres

This study examined the phytochemical profiles and bioactive potential of Iris alberti, I. pallasii, and I. sogdiana collected from southeastern Kazakhstan. GC-MS analysis identified fatty acids, sterols, long-chain alcohols, and hydrocarbons in each species. The key phytosterols β-sitosterol, stigmasterol, and campesterol were …

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GENUS IRIS L. IN KAZAKHSTAN – FROM N. V. PAVLOV TO THE PRESENT DAY

Madina Ramazanova, Anna Ivaschenko, Lyudmila Grudzinskaya, Н. Г. Гемеджиева

В статье дан обзор литературных и экспериментальных данных по изученности видов рода в Казахстане – от Н. В. Павлова до наших дней

Final data on the efficacy of the FORA study (FOrteca Real practice Assessment): a multicenter prospective observational study on the real-world efficacy of prolgolimab in patients with metastatic melanoma in Russia

Кристина Вячеславовна Орлова, Mikhail Yu. Fedyanin, Konstantin E. Simanenkov, Aleksandr S. Dergunov et autres

Background. Prior to the introduction of new agents — immune checkpoint inhibitors — for inoperable and/or metastatic melanoma (IMM), chemotherapy outcomes were generally poor. The median (Me) overall survival (OS) in IMM was no more than 6-9 months, and the Me of …

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Preservation of ex-situ gene pool of rare medicinal plant species in Kazakhstan

R. B. Arysbaeva, Zhanat Karzhaubekova, Madina Ramazanova, Ludmila Grudzinskaya et autres

The approved “List of Medicinal Plants” consists of 278 medicinal plants used in official or traditional medicine. At the same time, 65 species have been listed in the Red Book of Kazakhstan. In the experimental medicinal plant collections located in the foothills …

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

Gaziza Zhumaliyeva, Aizhan I. Zhussupova, Galiya E. Zhusupova, Ewelina Maria Błońska-Sikora et autres

The study of medicinal plants is important, as they are the natural reserve of potent biologically active compounds. With wide use in traditional medicine and the inclusion of several species (as parts and as a whole plant) in pharmacopeia, species from the …

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Anatomical and morphological study of the roots of species of the genus Iris from natural populations of southeastern Kazakhstan

Madina Ramazanova, N. V. Kurbatova, Nadezhda Gemejiyeva, Ch. J Aldassugurova

Wild-growing species of the genus Iris L. are perennial rhizomatous plants better known for decorative properties and promising plants as sources of medicinal raw materials. Irises contain essential oil, isoflavones, flavonoids, carotenoids, various organic acids, and tannins. The rhizomes of some irises …

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Сравнительное анатомо-морфологическое исследование вегетативных органов Iris sogdiana Bunge из природных популяций юго-восточного Казахстана

Madina Ramazanova, Natalja Kurbatova

Сравнительный анатомо-морфологический анализ вегетативных органов Iris sogdiana из различных условий произрастания представляет интерес, поскольку позволяет выявить особенности и адаптационные возможности вида. Микроскопические исследования вегетативных органов I. sogdiana из природных популяций юго-восточного Казахстана проведены впервые. Показана положительная корреляция между местообитанием и морфометрическими параметрами …

Интродукция Казахстанских видов Ирисов

Madina Ramazanova, L. M. Grudzinskaya, Nadezhda Gemejiyeva

According to various sources 19 (22) species are found in the flora of Kazakhstan except 3 rare species (Iris alberti Regel, I. ludwigii Maxim, I. tigridia Bunge) and endemics I. ludwigii, I. alberti. Eight species are used in folk medicine. Most of …

Ирисы Юго-Восточного Казахстана и перспективы их использования как источников сырья для отечественных фитопрепаратов

Н. Г. Гемеджиева, Madina Ramazanova

В статье дан аналитический обзор современного состояния изученности ирисов Юго-ВосточногоКазахстана из семейства Iridaceae Juss. и показаны перспективы изучения и использования их в качестве источников возобновляемого растительного сырья для получения отечественных фитопрепаратов.

Phase 2 Multicenter Single-Arm Study of Second-Line Axitinib in Favorable Risk Patients with Metastatic Renal Cell Carcinoma: FavorAx

Ilya V. Tsimafeyeu, Pavel S. Borisov, Ahmed Abdelgafur, Roman Leonenkov et autres

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