Anna Napoli

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giacomina Brunetti, Angela Oranger, Isabella Gigante, Giorgio Mori et autres

LIGHT/TNFSF14, a member of the tumor necrosis factor superfamily, is known to play a major role in T-cell homeostasis, whereas its effect on osteoclastogenesis is controversial. Here, we investigated LIGHT involvement in bone cell differentiation as well as in the bone-disease associated …

Molecular monitoring of viral infections in immunocompromised patients in a large university hospital in Italy: reflections after thirteen years of real-life activity

Lilia Cinti, Piergiorgio Roberto, Matteo A. C. Rossi, Anna Napoli et autres

PURPOSE: This study aimed to investigate the prevalence and viral reactivations of clinical interest in the immunocompromised patient with particular focus on hematologic and solid organ transplant recipients. METHODS: Molecular screening data of CMV, EBV, JCV and BKV from 2011 to 2023 …

it (code pays fourni par la source)

The Long-Term Immunogenicity of mRNABNT162b Third Vaccine Dose in Solid Organ Transplant Recipients

Maria Antonella Zingaropoli, Mariasilvia Guardiani, Federica Dominelli, Eeva Tortellini et autres

We investigated humoral and T-cell response to a SARS-CoV-2 mRNA vaccine in solid organ transplant recipients (SOT-Rs) and healthy donors (HDs) before (T0) and after two (T1) and twelve months (T2) since the third dose administration. SOT-Rs were stratified according to the …

it (code pays fourni par la source)

SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience

Federica Pulvirenti, Giulia Garzi, Cinzia Milito, Eleonora Sculco et autres

Background: Preventive strategies against severe COVID-19 in Inborn Errors of Immunity (IEI) include bivalent vaccines, treatment with SARS-CoV-2 monoclonal antibodies (mAbs), early antiviral therapies, and pre-exposure prophylaxis (PrEP). Objective: To assess the effectiveness of the PrEP with tixagevimab/cilgavimab (AZD7442) in IEI with …

it (code pays fourni par la source)

Differential expression of Type I interferon and inflammatory genes in SARS‐CoV‐2‐infected patients treated with monoclonal antibodies

Luca Maddaloni, Letizia Santinelli, Ginevra Bugani, Elio Gentilini Cacciola et autres

INTRODUCTION: Considering the reported efficacy of monoclonal antibodies (mAbs) directed against the Spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in reducing disease severity, the aim of this study was to investigate the innate immune response before and after …

it (code pays fourni par la source)

Adherence to SARS-CoV-2 Vaccination Recommendations among Patients with Substance Use Disorders: A Cross-Sectional Study in Rome, Italy

Francesco Mondera, Vincenzo Cammalleri, Francesca Maria Forestiero, Federica Turatto et autres

Adherence to vaccination recommendations is a challenge for national immunization programs. We quantified adherence to COVID-19 vaccination recommendations in people with substance use disorders (SUDs) attending an outpatient addiction center in Rome, Italy; we investigated the determinants of adherence, and also analyzed …

it (code pays fourni par la source)

Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design

Giuseppe La Torre, Gianluca Paglione, Lavinia Barone, Vittoria Cammalleri et autres

OBJECTIVE: The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those …

it (code pays fourni par la source)

Anti-N SARS-CoV-2 assays for evaluation of natural viral infection

Aurelia Gaeta, Antonio Angeloni, Anna Napoli, B. Pucci et autres

BACKGROUND: The 2019 coronavirus (COVID-19) epidemic, required the development of different diagnostic tests. While reverse transcriptase real-time PCR (RT-PCR) remains the first-line test of choice in acute infection diagnosis, anti-N antibodies serological assays provide a valuable tool to differentiate natural SARS-CoV-2 immunological …

it (code pays fourni par la source)

Differential expression of type I interferon and inflammatory genes in SARS-CoV-2 infected patients treated with monoclonal antibodies

Giancarlo Ceccarelli, Luca Maddaloni, Letizia Santinelli, Ginevra Bugani et autres

Considering the efficacy of monoclonal antibodies (mAbs) directed against the Spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in reducing disease severity, the aim of this study was to investigate the innate immune response before and after mAbs treatment …

it (code pays fourni par la source)

Torque teno virus (TTV): A gentle spy virus of immune status, predictive marker of seroconversion to COVID‐19 vaccine in kidney and lung transplant recipients

Piergiorgio Roberto, Lilia Cinti, Anna Napoli, D. Paesani et autres

Abstract To date, no comprehensive marker to monitor the immune status of patients is available. Given that Torque teno virus (TTV), a known human virome component, has previously been identified as a marker of immunocompetence, it was retrospectively investigated whether TTV viral …

it (code pays fourni par la source)

Multiple sclerosis-disease modifying therapies affect humoral and T-cell response to mRNA COVID-19 vaccine

Federica Dominelli, Maria Antonella Zingaropoli, Matteo Tartaglia, Eeva Tortellini et autres

Background: The mRNA vaccines help protect from COVID-19 severity, however multiple sclerosis (MS) disease modifying therapies (DMTs) might affect the development of humoral and T-cell specific response to vaccination. Methods: The aim of the study was to evaluate humoral and specific T-cell …

it (code pays fourni par la source)

Quality of T-Cell Response to SARS-CoV-2 mRNA Vaccine in ART-Treated PLWH

Eeva Tortellini, Maria Antonella Zingaropoli, Giulia Mancarella, Raffaella Marocco et autres

We investigated specific humoral and T-cell responses in people living with HIV (PLWH) before (T0), after two (T1) and after six months (T2) from the third dose of the BNT162b2 vaccine. Healthy donors (HD) were enrolled. The specific humoral response was present …

it (code pays fourni par la source)