Robert E. MacKenzie

S12 Improving safety and TReatment precision for acute COPD exacerbations (TRACE): feasibility of point-of-care testing in community pharmacies. A qualitative study

TH Harries, Robert E. MacKenzie, M Bafadhel, Richard E. K. Russell et autres

Introduction and Objectives Acute COPD exacerbations (AECOPDs) account for 11% of primary care antibiotic prescriptions & up to 40% of patients receive repeated oral corticosteroids (OCS). Without objective markers, prescribing decisions rely on symptoms and examination, without test corroboration. Drug rescue packs …

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A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development

Karen E. Christensen, Lin Deng, Kit‐Yi Leung, Erland Arning et autres

Genetic variants in one-carbon folate metabolism have been identified as risk factors for disease because they may impair the production or use of one-carbon folates required for nucleotide synthesis and methylation. p.R653Q (1958G>A) is a single-nucleotide polymorphism (SNP) in the 10-formyltetrahydrofolate (formylTHF) …

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Erratum to “Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes” [Bioorg. Med. Chem. Lett. 22 (2012) 1464–1468]

Jon M. Sutton, David E. Clark, Stephen J. Dunsdon, Garry Fenton et autres

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Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes

Jon M. Sutton, David E. Clark, Stephen J. Dunsdon, Garry Fenton et autres

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Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes II: Optimisation of the PK profile

Jon M. Sutton, Daniel J. Clark, Jane Elizabeth Dunsdon, Garry Fenton et autres

Optimisation of compounds from a series of deazaxanthines is described. SAR from the deazahypoxanthine series described previously was used to design improved deazaxanthine-based DPP-4 inhibitors which not only exhibited excellent activity and selectivity but showed improved in vivo activity due to an …

CRYSTAL STRUCTURE OF HUMAN DPP4 IN COMPLEX WITH A NOVAL HETEROCYCLIC DPP4 INHIBITOR

Nils Ostermann, M. Kroemer, Florence Zink, Bernd Gerhartz et autres

ChemInform Abstract: Silicon Diols: Effective Inhibitors of Human Leukocyte Elastase

Graham A. Showell, John G. Montana, Jenny A. Chadwick, Chris Higgs et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

Karen E. Christensen, Charles V. Rohlicek, Grégor Andelfinger, Jacques L. Michaud et autres

Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis. A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD). To examine the biological impact of this variant on …

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Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains

W. H. Miller, Deanna F. Graham, K. Bishop Douglas, Robert E. MacKenzie et autres

Chapter 14 Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase, and Formyltetrahydrofolate Synthetases

Karen E. Christensen, Robert E. MacKenzie

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Mitochondrial one‐carbon metabolism is adapted to the specific needs of yeast, plants and mammals

Karen E. Christensen, Robert E. MacKenzie

In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic purine synthesis through the generation of formate. This pathway is important but …

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NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase–cyclohydrolases can rescue mthfd2 null fibroblasts

Harshila Patel, Erminia Di Pietro, Narciso R. Mejia, Robert E. MacKenzie

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