Mahta Mardani

Comparison of safety and efficacy of lower-intensity versus standard unfractionated heparin infusion nomograms for extracranial venous thromboembolism in the neurological intensive care unit

Abdullah M Hakoun, Megha Gupta, Rajat Dhar, Mahta Mardani et autres

BACKGROUND: Anticoagulation for acute venous thromboembolism (VTE) in the neurological intensive care unit is challenging because patients with acute brain injury or recent neurosurgery are at high risk for hemorrhagic complications. Unfractionated heparin infusions are commonly used, sometimes with lower activated partial …

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CDK4/6 inhibitor ribociclib and doxorubicin combination treatment inhibits breast cancer bone metastasis and enhances T-cell targeted therapy

Xinming Su, Takayuki Kobayashi, Jingyu Xiang, Yalin Xu et autres

CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy, specifically aromatase inhibitors or selective estrogen receptor degraders or modulators, have significantly improved outcomes for advanced estrogen receptor-positive (ER + ) breast cancer; however, therapeutic resistance remains a primary cause of mortality. Overcoming CDK4/6i treatment …

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Abstract 5333: CDK4/6 inhibitors in patients with bone-only metastatic breast cancer, the role of immune microenvironment

Mahta Mardani, Suleyman Noordeen, Katherine Clifton, Cynthia X. Ma et autres

Abstract Background: CDK4/6 inhibitors (CDK4/6i) have revolutionized HR+ metastatic breast cancer treatment. Trials like PALOMA, MONALEESA, and MONARCH showed improved progression-free survival (PFS) with endocrine therapy (ET), establishing it as first-line treatment. Bone metastases are common in HR+ breast cancer, with 40% …

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Abstract 1212: Disruption of Gαs/cAMP-mediated acid sensing by breast tumor cells blunts tumor-induced immune suppression and decreases bone metastases by enhancing cytotoxic T cell function

Kaylee M. O'Donnell, Xinming Su, Netra Navadkar, Yalin Xu et autres

Abstract Patients with bone metastases treated with immune checkpoint blockade (ICB) often have decreased response rates compared to patients with visceral metastases only. Increased proton extrusion by tumor cells due to the Warburg effect is associated with tumor progression, metastasis, reduced efficacy …

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Remission of longstanding metastatic paraganglioma in a patient after use of zoledronic acid

Mahta Mardani, Katherine N. Weilbaecher, Vikas Prasad, John S.A. Chrisinger et autres

A patient with a long history of bone predominant, metastatic paraganglioma who had multiple episodes of progressive disease despite prior treatments demonstrated a remarkable disease response to zoledronic acid. After 1 year of treatment, there was a complete resolution of lymphadenopathy and …

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Abstract PO5-05-05: Clinical outcomes of CDK4/6 inhibitors in patients with bone only metastatic breast cancer

Mahta Mardani, Suleyman Noordeen, Katherine Clifton, Cynthia X. Ma et autres

Abstract Background: CDK4/6 inhibitors (CDK 4/6i) have significantly advanced the treatment of hormone receptor-positive (HR+) metastatic breast cancer in the last decade. Several clinical trials including PALOMA, MONALEESA, and MONARCH have shown improved progression-free survival (PFS) rates when CDK4/6i were combined with …

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CDK4/6 inhibitor and doxorubicin synergistically inhibit breast cancer bone metastasis and enhance T-cell targeted therapy

Xinming Su, Takayuki Kobayashi, Jingyu Xiang, Yalin Xu et autres

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Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi et autres

BACKGROUND: Allo-HSCT is a definite approach for the management of a wide variety of lethal and debilitating malignant and non-malignant disorders. However, its two main complications, acute and chronic graft-versus-host disease (GVHD), exert significant morbidities and mortalities. BoS, as a manifestation of …

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A systematic method introduced a common lncRNA-miRNA-mRNA network in the different stages of prostate cancer

Gelareh Vahabzadeh, Solmaz Khalighfard, Ali Mohammad Alizadeh, Mahsa Yaghobinejad et autres

Introduction: The present study aimed to investigate the interaction of the common lncRNA-miRNA-mRNA network involved in signaling pathways in different stages of prostate cancer (PCa) by using bioinformatics and experimental methods. Methods: Seventy subjects included sixty PCa patients in Local, Locally Advanced, …

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Fanconi anemia phenotypic and transplant outcomes' associations in Iranian patients

Faezeh Ansari, Maryam Behfar, Parisa Naji, Zahra Darvish et autres

Abstract Objectives Fanconi anemia (FA) is a rare, heterogeneous, inherited disorder. Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only therapeutic option to restore normal hematopoiesis. This study reports the outcomes of FA‐HSCT patients and identifies factors, including clinical phenotype. Our team …

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Organ‐based clues for diagnosis of inborn errors of immunity: A practical guide for clinicians

Fatemeh Mohammadi, Amirhossein Yadegar, Mahta Mardani, Aryan Ayati et autres

Inborn errors of immunity (IEI) comprise a group of about 490 genetic disorders that lead to aberrant functioning or the development of distinct immune system components. So far, a broad spectrum of IEI-related manifestations has been noted in the literature. Due to …

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Total body irradiation‐free haploidentical peripheral blood stem cell transplantation compared to related and unrelated donor transplantation in pediatrics with acute lymphoblastic leukemia

Mahta Mardani, Maryam Behfar, Leila Jafari, Rashin Mohseni et autres

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer under the age of 15 years. Despite the recent advances in therapeutic regimens, relapse occurs in 15%-20% of pediatric patients after chemotherapy, and hematopoietic stem cell transplantation (HSCT) is the best …

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