T. Hansen

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Raimo Joro, John A. Curtin, R.L. Hanson, Niina Pitkänen et autres

Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated …

us (code pays fourni par la source)

A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants

Timon W. van Haeften, R.N. Bergman, Oluf Borbye Pedersen, N. Wang et autres

Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genomewide association study of first-phase insulin secretion, as measured by intravenous glucose tolerance …

us (code pays fourni par la source)

Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation

T. Hansen, H. Eiberg, M. Rouard, M. Vaxillaire et autres