Walid T. Khaled

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation

Mahmood H. Dalhat, Sharath Narayan, Maria Eleftheriou, James Russell et autres

N-acetyltransferase 10 (NAT10) is a multifunctional enzyme that harbors RNA acetyltransferase and RNA helicase domains and has emerged as a therapeutic vulnerability in solid and hematological malignancies. By coupling Proteolysis Targeting Chimera-mediated degradation of NAT10 with a deep mutational scanning assay, followed …

us, gb (code pays fourni par la source)

A mouse mammary gland atlas investigating effects of aging, parity, and Brca1, Brca2, Palb2 germline mutations

Walid T. Khaled, LJ Porter, Y Zhang

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Abstract 158: PI3Kδ in CD4+ T cells protects against lung metastases through IFNγ-induced tumor senescence.

Leqi Tang, Grace E. Cooper, LJ Porter, Seung Joon Kim et autres

Abstract PI3Kδ is a key lymphocyte signaling hub for manipulating antitumor immunity. In cancer, most work has centered on inhibiting PI3Kδ, particularly in regulatory T cells, to relieve immunosuppression and enhance effector T cell control of established tumors. Yet lung metastasis remains …

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Rank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis

Jaime Redondo-Pedraza, Patricia G. Santamaría, Alejandro Sanchez-Juan, María Jimenez et autres

Rank signaling regulates mammary gland development and epithelial differentiation. While Rank is expressed in both basal and luminal cells, its basal-specific role is unclear. Here, using inducible basal-specific Rank expression and lineage tracing, we show that Rank signaling regulates basal cell identity …

es, no, gb, us, fr (code pays fourni par la source)

Supplementary Figure S10 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Analysis of in vivo infections with Tp53 and Rb1 adenoviruses.

Supplementary Table 3 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

List of BaseScope probes used in study

Supplementary Table 1 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

List of primers used in studies

Supplementary Methods 1 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

Supplemental methods and references

Supplementary Figure S8 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

analysis of Ad-PR infected lungs at 6-months

Supplementary Figure S5 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

H&E stained NMR lung tissue from control and Eml4-Alk infections

Supplementary Figure S2 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Assessing NMR adenovirus infections of lungs

Data from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Abstract There is growing interest in understanding the mechanisms underlying differences in cancer incidence among species (comparative oncology). The naked mole rat (NMR) is often referenced as “cancer resistant” and prior studies focused on identifying mechanisms explaining this. However, efforts to assess …