Aditya Mahadevan

Comparative Risk of Cardiovascular Hospitalization With Immune Checkpoint Inhibitors Versus Chemotherapy

Aidan Vosooghi, Aditya Mahadevan, Jagmeet S. Arora, Theresa Farhat et autres

PURPOSE: While immune checkpoint inhibitors (ICIs) are associated with rare, acute myocarditis, their comparative impact on chronic vascular events and heart failure versus conventional chemotherapy remains ill-defined. We compared the 2-year risk of hospitalization for major adverse cardiovascular events (MACEs) after ICI …

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The germline MLH1 c.2054 C>T mutation disrupts DNA mismatch repair and is detectable by digital PCR

Matthew R. Moldenhauer, Aditya Mahadevan, Cameron Hom, Angie Nguyen et autres

Lynch syndrome significantly increases the risk of developing colorectal cancer (CRC) due to an inherited defect in mismatch repair (MMR). Early detection relies on the identification of pathogenic mutations in patients with a family history of cancer, but few canonical Lynch mutations …

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Gastroesophageal malignancies are associated with poorer outcomes in young patients seen in California comprehensive Cancer Centers

Armon Azizi, Aditya Mahadevan, Elaine Chiao, Maheswari Senthil et autres

Abstract While the overall incidence of adenocarcinomas of the stomach and esophagus (GEA) has been declining in the United States, there has been an increase in cases among those under 50. Clinical and demographic data on GEA in young patients, especially in …

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Abstract 7228: A novel digital PCR assay can detect MLH1 variants in patients with hereditary colorectal cancer

Matthew R. Moldenhauer, Aditya Mahadevan, Cameron Hom, Valeria Rangel et autres

Abstract Background: Lynch syndrome significantly increases the risk of developing colorectal cancer (CRC) due to an inherited defect in mismatch repair (MMR). Early detection relies on identification of pathogenic mutations in patients, but few canonical Lynch mutations exist. We describe two separate …

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Low-temperature transition of 2d random-bond Ising model and quantum infinite randomness

Akshat Pandey, Aditya Mahadevan, A. Alan Middleton, Daniel S. Fisher

At low temperatures, the classical two-dimensional random bond Ising model undergoes a frustration-driven ferromagnet-to-paramagnet transition controlled by a zero-temperature fixed point separating ferromagnet and spin glass phases. We show that this critical point can be understood through a renormalization group transformation that …

Low-temperature transition of 2d random-bond Ising model and quantum infinite randomness

Akshat Pandey, Aditya Mahadevan, A. Alan Middleton, Daniel S. Fisher

At low temperatures, the classical two-dimensional random bond Ising model undergoes a frustration-driven ferromagnet-to-paramagnet transition controlled by a zero-temperature fixed point separating ferromagnet and spin glass phases. We show that this critical point can be understood through a renormalization group transformation that …

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Performance Analysis of Cooperative Relays in 5G Wireless High Speed Train Communication

M. Bindhu, P. Pattunnarajam, Sabareeswari, A. N. Duraivel et autres

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Understanding Patient and Oncologist Preferences in the Management of Metastatic Renal Cell Carcinoma

Omid Yazdanpanah, Aditya Mahadevan, David Joseph Benjamin, Elham Vosoughi et autres

INTRODUCTION: Treatment of metastatic renal cell carcinoma (mRCC) has expanded with development of combination therapies containing tyrosine kinase inhibitors (TKIs) with immune checkpoint inhibitors (ICI) agents or dual ICI agents. However, patient preferences may not necessarily be incorporated into management decisions. We …

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Adequate Catchment Area Representation in Cancer Clinical Trials at NCI Designated Cancer Centers: The University of California Irvine Experience

Frank Lee, Aditya Mahadevan, Armon Azizi, Jennifer Valerin et autres

BACKGROUND: Ensuring that clinical trial enrollment reflects the demographics and disease burden of a cancer center's catchment area is essential for improving trial accrual and the generalizability of research findings. We hypothesized that aligning the clinical trial portfolio with the needs of …

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Risk of developing hematologic malignancy in patients with autoimmune and inflammatory skin diseases

Jagmeet S. Arora, Aditya Mahadevan, Janellen Smith, Michelle S. Min

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Identifying Clinical Determinants of Intrafraction Motion during Spine Stereotactic Body Radiotherapy

Kara Banson, Matthew E Schelin, Jason Gurewitz, Kenneth Bernstein et autres

First-line use of antiangiogenic agents in unresectable hepatocellular carcinoma: a double-edged sword?

Aditya Mahadevan, Armon Azizi, Nadine Abi‐Jaoudeh, Jennifer Valerin et autres

Treatment options for hepatocellular carcinoma (HCC), the most prevalent primary liver malignancy, have historically been limited, particularly in unresectable cases with underlying cirrhosis. Initial systemic therapy with antiangiogenic agents, notably vascular endothelial growth factor (VEGF) inhibitors such as sorafenib, showed modest survival …

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