Si‐Yeon Jeong

How Taxpayer Perceptions Influence the Utilization of Charitable Tax Credits

Korean Academic Society of Taxation, Si‐Yeon Jeong, Da-Eun Kang

This study empirically investigates the impact of taxpayers’ subjective perceptions on the active utilization of charitable tax credits as a key behavior in leveraging tax policies, shifting the focus beyond tax compliance. Using a lagged panel structure from the 10th and 11th …

Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Pena Martinez, Alexis Rickman et autres

Alzheimer's disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death Induced by Survival gene Elimination (DISE) is a cell death mechanism mediated by short (s) RNAs acting through the RNA-induced silencing complex …

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The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference

Andrea E. Murmann, Monal Patel, Si‐Yeon Jeong, Elizabeth T. Bartom et autres

Extended CAG trinucleotide repeats (TNR) in the genes huntingtin (HTT) and androgen receptor (AR) are the cause of two progressive neurodegenerative disorders: Huntington's disease (HD) and Spinal and Bulbar Muscular Atrophy (SBMA), respectively. Anyone who inherits the mutant gene in the complete …

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Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Pena Martinez, Alexis Rickman et autres

Abstract Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death Induced by Survival gene Elimination (DISE) is a cell death mechanism mediated by short (s) RNAs acting through the RNA induced …

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Public Health Emergency Preparedness and Response by Regulatory Authorities in South Korea, United States, and Europe

Sun‐Young Kim, YeonGyeong Han, EunHui Moon, SeokYeon Kang et autres

Since the outbreak of the new strain of coronavirus (SARS-CoV-2, COVID-19) was first reported, regulatory authorities worldwide have issued various regulatory guidelines and recommendations. Global authorities are committed to supporting developers of potential vaccines and treatments for COVID-19. This study reviewed the …

Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Jing Li, Si‐Yeon Jeong, Bei Xiong, Alan Tseng et autres

Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation and vaso-occlusion in sickle cell disease. In the present study, we demonstrated that pyridoxamine, a derivative of vitamin B6, might be a therapeutic agent to alleviate intravascular cell-cell aggregation in sickle cell …

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Abstract 285: Short- and Long-term Treatment of Pyridoxamine, an Inhibitor of Advanced Glycation End Products, Attenuates Platelet-neutrophil Interactions and Vascular Occlusion in Sickle Cell Disease

Jing Li, Si‐Yeon Jeong, Bei Xiong, Alan Tseng et autres

Sickle cell disease (SCD) is an inherited blood disorder, leading to sickling and hemolysis of red blood cells, activation of intravascular cells, and chronic inflammation. Recurrent vaso-occlusion (VOC) is the hallmark of SCD and results from intravascular cell-cell interactions. VOC is a …

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Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

Jing Li, Kyungho Kim, Si‐Yeon Jeong, Joyce Chiu et autres

BACKGROUND: Platelet-neutrophil interactions contribute to vascular occlusion and tissue damage in thromboinflammatory disease. Platelet glycoprotein Ibα (GPIbα), a key receptor for the cell-cell interaction, is believed to be constitutively active for ligand binding. Here, we established the role of platelet-derived protein disulfide …

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Estrogenic effects of phytoestrogens derived from Flemingia strobilifera in MCF-7 cells and immature rats

Si‐Yeon Jeong, Minsun Chang, Sangho Choi, Sei‐Ryang Oh et autres

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Neuroprotective effect of mesenchymal stem cell through complement component 3 downregulation after transient focal cerebral ischemia in mice

Hye-Seon Jung, Si‐Yeon Jeong, Jiwon Yang, Sodam Kim et autres

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Activation of microglial Toll‐like receptor 3 promotes neuronal survival against cerebral ischemia

Si‐Yeon Jeong, Raok Jeon, Yoon Kyung Choi, Joo Eun Jung et autres

Emerging experimental evidence suggests that activation of Toll-like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly-ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown. In the brain, TLR3 is mostly expressed in glial cells. Therefore, we …

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Isoguaiacins, Arylnaphthalene Types Identified as Novel Potent Estrogenic Signaling Molecules from Larrea nitida

Si‐Yeon Jeong, Hye‐na Ahn, Gyu‐Un Bae, Minsun Chang et autres

In our study on the biological activities of isoguaiacins, we demonstrated lignans with a rigid structure from Larrea nitida as selective estrogen receptor modulators (SERMs). Estrogenic activity‐guided isolation of the L. nitida extract led to the identification of four lignans compounds. All …

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