BA Borlaug

Adults with Fontan circulation: prognostic value of exercise pulmonary vascular resistance index

Jacob Cao, A. Egbe, Nick Olsen, C Charles Jain et autres

BACKGROUND AND AIMS: Decrease in pulmonary vascular resistance (PVR) during exercise confers favourable prognosis in biventricular physiology, but its role in Fontan circulation remains unknown. This study aimed to evaluate the prognostic value of PVR index (PVRI) response to exercise in adults …

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Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction

A Tada, Daniel Burkhoff, Jwan A. Naser, Tomonari Harada et autres

Abstract Background Systemic arterial compliance and venous capacitance are typically impaired in patients with heart failure with preserved ejection fraction (HFpEF), contributing to hemodynamic congestion with stress. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce hemodynamic congestion and improve clinical outcomes in patients with HFpEF, …

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The association between epicardial adipose tissue and prognosis in heart failure with preserved and reduced ejection fraction

NR Pugliese, Nicolò De Biase, Matteo Mazzola, Francesco Paneni et autres

Abstract Funding Acknowledgements Type of funding sources: None. Background. Recent evidence shows that increased epicardial adipose tissue (EAT) thickness is associated with metabolic syndrome, microvascular dysfunction and enhanced pericardial restraint. Purpose. We measured echocardiography-derived EAT thickness in a population of heart failure …

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The relationship of epicardial adipose tissue with hemodynamics and cardiopulmonary fitness in heart failure with preserved and reduced ejection fraction

NR Pugliese, Nicolò De Biase, Matteo Mazzola, Francesco Paneni et autres

Abstract Funding Acknowledgements Type of funding sources: None. Background. Recent evidence shows epicardial adipose tissue (EAT) acts as a paracrine organ and may directly alter myocardial function by exerting mechanical compression. Purpose. We evaluated EAT thickness through transthoracic echocardiography and investigated its …

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Prognostic significance of epicardial adipose tissue in heart failure with preserved and reduced ejection fraction

Nicola Riccardo Pugliese, Nicolò De Biase, Matteo Mazzola, Francesco Paneni et autres

Abstract Background Increased epicardial adipose tissue (EAT) thickness correlates with metabolic syndrome, insulin resistance, microvascular dysfunction and enhanced pericardial restraint. Purpose We measured echocardiographic EAT thickness in heart failure (HF) patients with reduced (HFrEF) or preserved (HFpEF) ejection fraction to determine whether …

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Epicardial adipose tissue, cardiovascular hemodynamics and metabolic profile in heart failure with preserved and reduced ejection fraction

Nicola Riccardo Pugliese, Matteo Mazzola, Nicolò De Biase, Francesco Paneni et autres

Abstract Background Epicardial adipose tissue (EAT) acts as a paracrine organ and could exert direct mechanical compression on the myocardium. Purpose We investigated the impact of echocardiographic EAT thickness on metabolic profile and cardiovascular hemodynamics at rest and during exercise in heart …

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Cardiac reserve and exercise capacity: insights from combined cardiopulmonary and exercise echocardiography stress testing

NR Pugliese, Nicolò De Biase, Luca Conte, Luna Gargani et autres

Abstract Funding Acknowledgements Type of funding sources: None. Aims. Combined cardiopulmonary exercise test (CPET) and exercise stress echocardiography (ESE) provides a non-invasive tool to study cardiopulmonary pathophysiology. We analyzed how cardiac functional reserve during exercise relates to peak oxygen consumption (VO2). Methods …

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Predicting heart failure transition and progression: a weighted risk score from bio-humoral, cardiopulmonary and echocardiographic stress testing

NR Pugliese, Nicolò De Biase, Lorenzo Conte, Luna Gargani et autres

Abstract Funding Acknowledgements Type of funding sources: None. Aims. We tested the prognostic role of a risk score including bio-humoral evaluation, cardiopulmonary-echocardiographic stress (CPET-ESE) and lung ultrasound, in patients with heart failure (HF) with reduced and preserved ejection fraction (HFrEF and HFpEF), …

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Cause-specific mortality and heart failure readmissions according to the HFA-PEFF algorithm in patients hospitalised for heart failure with preserved ejection fraction

Frederik H. Verbrugge, Yogesh N.V. Reddy, R.E Carter, BA Borlaug

Abstract Background The HFA-PEFF algorithm has been recently developed and is recommended by the European Society of Cardiology to make a diagnosis of heart failure with preserved ejection fraction (HFpEF). Based on functional echocardiography criteria, morphological criteria, and natriuretic peptide levels, a …

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Non-invasive vocal biomarker is associated with pulmonary hypertension

Jaskanwal Deep Singh Sara, Elad Maor, BA Borlaug, Diana M. Orbelo et autres

Abstract Background Heart failure (HF) is a debilitating disease and is associated with significant morbidity and mortality, and costs to health care systems. Monitoring the impact of therapy remotely holds the potential to reduce HF-related hospitalizations, improve quality of life, and optimize …

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P2600The impact of pulmonary vascular resistance on fontan hemodynamics and outcomes

A Egbe, Mona Alotaibi, BA Borlaug

Background: Central venous pressure (CVP) provides the driving force for pulmonary blood flow in Fontan physiology, and it is dependent on pulmonary vascular resistance index (PVRI), ventricular filling pressure and venous compliance. The relationship between CVP and PVRI in the Fontan physiology …

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Errata

JC Fang, Teresa DeMarco, MM Givertz, BA Borlaug et autres