Faith R. Kreitzer

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors

Toni Kline, Cong Xu, Faith R. Kreitzer, Dow P. Hurst et autres

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Design, Synthesis, and Evaluation of Substituted Alkylindoles that Activate G Protein-Coupled Receptors Distinct from the Cannabinoid Cb1 and Cb2 Receptors

Toni Kline, Cong Xu, Faith R. Kreitzer, Dow P. Hurst et autres

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Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome

Hiroko Nobuta, Maria Roberta Cilio, Olivier Danhaive, Hui‐Hsin Tsai et autres

Human congenital central hypoventilation syndrome (CCHS), resulting from mutations in transcription factor PHOX2B, manifests with impaired responses to hypoxemia and hypercapnia especially during sleep. To identify brainstem structures developmentally affected in CCHS, we analyzed two postmortem neonatal-lethal cases with confirmed polyalanine repeat …

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Abstracts

Li Bie, Yo‐El S. Ju, Loretta Donovan, S. Birks et autres

INTRODUCTION: Ginsenoside Rg3 is a natural active ingredient that is extracted from Korean red ginseng root.It elevates therapeutic effect of radiotherapy and chemotherapy, but the study found that the application of Rg3 is heavily limited by its low bioavailability and poor absorption …

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A robust method to derive functional neural crest cells from human pluripotent stem cells.

Faith R. Kreitzer, Nathan Salomonis, Alice Sheehan, Miller Huang et autres

Neural crest (NC) cells contribute to the development of many complex tissues of all three germ layers during embryogenesis, and its abnormal development accounts for several congenital birth defects. Generating NC cells-including specific subpopulations such as cranial, cardiac, and trunk NC cells-from …

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Humanized Mouse Models for Medulloblastoma

Miller Huang, Anders I. Persson, Fredrik J. Swartling, Branden S. Moriarity et autres

Binding of NIR-conPK and NIR-6T to Astrocytomas and Microglial Cells: Evidence for a Protein Related to TSPO

Michelle Sexton, Grace Woodruff, Eiron Cudaback, Faith R. Kreitzer et autres

PK 11195 and DAA1106 bind with high-affinity to the translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). TSPO expression in glial cells increases in response to cytokines and pathological stimuli. Accordingly, [(11)C]-PK 11195 and [(11)C]-DAA1106 are recognized molecular imaging (MI) …

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The therapeutic potential of novel cannabinoid receptors

Faith R. Kreitzer, Nephi Stella

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