Daisuke Kawakami

Sex-Based Differences in the Vitamin D Metabolite Ratio and Its Associated Factors Among Healthy Japanese Adults: A Cross-Sectional Study

Hiroyasu Miyamoto, Reiko Kisugi, Ayasa Tajima, Masaki Miyasaka et autres

Background/Objectives: Vitamin D is a pleiotropic substance that plays a pivotal role in the human body. Several studies have suggested sex-based differences in vitamin D metabolism. Recently, the vitamin D metabolite ratio (VMR), defined as the ratio of serum 24,25-dihydroxyvitamin D [24,25(OH)2D] …

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Long-term outcomes in the pre-moyamoya stage of RNF213-related vasculopathy presenting with ischaemic stroke or transient ischaemic attack: insights from the NCVC Genome Registry

Takeshi Yoshimoto, Yorito Hattori, Hiroyuki Ishiyama, Eri Kiyoshige et autres

Background RNF213 is a susceptibility gene for moyamoya disease, with the p.R4810K variant being the founder mutation. However, long-term outcomes in non-moyamoya stage of RNF213 -related vasculopathy remain poorly characterised in longitudinal studies. Methods This multicentre, prospective, longitudinal study was conducted from …

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Corrigendum to ‘Determination of a serum 25-hydroxyvitamin D reference ranges in Japanese adults using fully automated liquid chromatography tandem mass spectrometry’ [J. Nutr. 2023; 153: 1253-1264]

Hiroyasu Miyamoto, Daisuke Kawakami, Nobuhiro Hanafusa, Tsuyoshi Nakanishi et autres

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The Preanalytical Process Matters: Impact of Blood Collection Tubes on the Measurement of Vitamin D Using Liquid Chromatography Tandem Mass Spectrometry

Sae Ochi, Akihiro Kunisawa, Tomokazu Matsuura, Hiroyasu Miyamoto et autres

BACKGROUND: Liquid chromatography tandem mass spectrometry (LC-MS/MS) is a highly sensitive analytical tool that has become the gold standard for measuring the concentrations of some steroidal hormones and therapeutic drugs in blood. However, the application of this technology in different clinical laboratories …

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Modeling Language for Scenario Development of Autonomous Driving Systems

Toshiaki Aoki, Takashi Tomita, Tatsuji Kawai, Daisuke Kawakami et autres

Autonomous driving systems are typically verified based on scenarios. To represent the positions and movements of cars in these scenarios, diagrams that utilize icons are typically employed. However, the interpretation of such diagrams is typically ambiguous, which can lead to misunderstandings among …

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Modeling Language for Scenario Development of Autonomous Driving Systems

Toshiaki Aoki, Takashi Tomita, Tatsuji Kawai, Daisuke Kawakami et autres

Autonomous driving systems are typically verified based on scenarios. To represent the positions and movements of cars in these scenarios, diagrams that utilize icons are typically employed. However, the interpretation of such diagrams is typically ambiguous, which can lead to misunderstandings among …

Specification-Based Testing of the Image-Recognition Performance of Automated Driving Systems

Kento Tanaka, Toshiaki Aoki, Takashi Tomita, Daisuke Kawakami et autres

Automated driving systems (ADSs) are complex entities comprising numerous components, and traditional testing methods often struggle to ensure their safety, primarily due to the diversity driving environments. Interestingly, deep neural networks (DNNs) have proven effective for object detection in these settings. The …

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Serum 25-hydroxyvitamin D quantitation by liquid chromatography-tandem mass spectrometry: Interference from blood collection tubes

Satoshi Ochi, Akihiro Kunisawa, Tomokazu Matsuura, Hiroshi Miyamoto et autres

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Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting

Tsutomu Shimada, Daisuke Kawakami, Arimi Fujita, Rintaro Yamamoto et autres

BACKGROUND: Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a CLAM-LC-MS/MS system, which consists of a sample preparation module directly connected to …

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Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack

Takeshi Yoshimoto, Hiroyuki Ishiyama, Yorito Hattori, Kunihiro Nishimura et autres

BACKGROUND AND AIMS: RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting a possible role of TPO-Ab as …

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Determination of a Serum 25-Hydroxyvitamin D Reference Ranges in Japanese Adults Using Fully Automated Liquid Chromatography–Tandem Mass Spectrometry

Hiroyasu Miyamoto, Daisuke Kawakami, Nobuhiro Hanafusa, Tsuyoshi Nakanishi et autres

BACKGROUND: Despite an increasing interest in vitamin D status, a reference range of the nutrient has not been fully established. This is partly due to a paucity of standardized measuring systems with high throughput. In addition, the range may vary by populations …

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Specification Based Testing of Object Detection for Automated Driving Systems via BBSL

Kento Tanaka, Toshiaki Aoki, Tatsuji Kawai, Takashi Tomita et autres

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