Rose C. Lopeman

Dynamic Culture Improves the Predictive Power of Bronchial and Alveolar Airway Models of SARS-CoV-2 Infection

Claire H Caygill, Rose C. Lopeman, Emily Richardson, Aitor Casas-Sánchez et autres

Abstract Human in vitro lung models represent advanced tools for studying respiratory infections, particularly those caused by emerging respiratory pathogens. Despite scientific advances, vaccine and therapeutics pre-clinical development has yet to fully adopt human-relevant testing platforms due in part to a lack …

gb, pt, Soudan du Sud (code pays fourni par la source)

Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters

Megan Neary, Eduardo Gallardo‐Toledo, Joanne Sharp, Joanne Herriott et autres

Favipiravir (FVP) and remdesivir (RDV) have demonstrable antiviral activity against SARS-CoV-2. Here, the efficacy of FVP, RDV, and FVP with RDV (FVP + RDV) in combination was assessed in Syrian golden hamsters challenged with SARS-CoV- 2 (B.1.1.7) following intraperitoneal administration. At day …

gb, ch (code pays fourni par la source)

Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters

Megan Neary, Eduardo; https://orcid.org/0009-0000-8534-9030 Gallardo-Toledo, Joanne; https://orcid.org/0000-0001-8482-5736 Sharp, Joanne Herriott et autres

Favipiravir (FVP) and remdesivir (RDV) have demonstrable antiviral activity against SARS-CoV-2. Here, the efficacy of FVP, RDV, and FVP with RDV (FVP + RDV) in combination was assessed in Syrian golden hamsters challenged with SARS-CoV- 2 (B.1.1.7) following intraperitoneal administration. At day …

Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters

Helen Box, Joanne Sharp, Shaun H. Pennington, Edyta Kijak et autres

OBJECTIVES: Antiviral interventions are required to complement vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data to support candidate plausibility are required. This work sought to further investigate the putative antiviral activity …

gb, us, be, ch (code pays fourni par la source)

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays

Helen Box, Shaun H. Pennington, Edyta Kijak, Lee Tatham et autres

Abstract Antiviral interventions are urgently required to support vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data in support of candidate plausibility are required. The speed at which preclinical models have been …

gb (code pays fourni par la source)

Remdesivir–ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H Caygill et autres

A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to increase the therapeutic index of drugs and …

gb (code pays fourni par la source)

Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2

Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H Caygill et autres

ABSTRACT A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy, the potential to increase the therapeutic index …

gb (code pays fourni par la source)

Author Correction: Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

Rose C. Lopeman, James Harrison, Daniel L. Rathbone, Maya Desai et autres

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

gb (code pays fourni par la source)

Treating multi-drug resistant Mycobacterium abscessus: three’s a charm

Rose C. Lopeman

Effect of Amoxicillin in combination with Imipenem-Relebactam against Mycobacterium abscessus

Rose C. Lopeman, James Harrison, Daniel L. Rathbone, Maya Desai et autres

Abstract Infections caused by Mycobacterium abscessus are increasing in prevalence in cystic fibrosis patients. This opportunistic pathogen′s intrinsic resistance to most antibiotics has perpetuated an urgent demand for new, more effective therapeutic interventions. Here we report a prospective advance in the treatment …

gb (code pays fourni par la source)

Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare

Rose C. Lopeman, James Harrison, Maya Desai, Jonathan A. G. Cox

Mycobacteria are a large family of over 100 species, most of which do not cause diseases in humans. The majority of the mycobacterial species are referred to as nontuberculous mycobacteria (NTM), meaning they are not the causative agent of tuberculous (TB) or …

gb (code pays fourni par la source)

Combining amoxicillin and relebactam provides new therapeutic potential for Mycobacterium abscessus infection

Rose C. Lopeman, James Harrison, Maya Desai, Peter A. Lambert et autres

Abstract Infections caused by the opportunistic pathogen Mycobacterium abscessus are increasing in prevalence within the cystic fibrosis population. Our limited understanding of this ubiquitous environmental microorganism matched with its intrinsic resistance to most classes of antibiotic, including β -lactams, has left us …

gb (code pays fourni par la source)