Zaid Sirhan

H2AX phosphorylation driven by the SET-PP2A axis maintains glioma stem cell properties

Chunhua Han, Na Li, Ananya Tina Banerjee, Linzhou Wang et autres

Glioblastoma harbors a subpopulation of glioma stem cells (GSCs) that drive tumor relapse and invasion. Although GSC properties are known to be regulated by key transcription factors and chromatin remodeling, the mechanisms governing stemness-associated gene expression and the role of histone proteins …

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Radiation-Induced HMGB2 Cytoplasmic Translocation Associates with Enhanced Immune Response Pathways in Glioma

A.P. Becker, V. Becker, Zaid Sirhan, Amy Webb et autres

PA2G4 as a Candidate Therapeutic Target in Pediatric Diffuse Gliomas

Zaid Sirhan, Blake E. Sells, J.L. Fleming, H. Manring et autres

Metformin-Based Combination Approaches for Triple-Negative Breast Cancer

Zaid Sirhan, Aya Abu Nada, Nadeen Anabtawi, Anita Thyagarajan et autres

Numerous anti-diabetic medications, including metformin, have been explored for their anticancer effects because of the substantial correlation between diabetes and cancer incidence. Metformin has recently gained interest for its anticancer effects against malignancies such as breast cancer, one of the leading causes …

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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer

Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

The integration between the tumor-suppressive and oncogenic signaling pathways controls various cellular activities of cancer cells, including cell growth and apoptosis. While the activation of oncogenes fuels cancer progression and escape mechanisms, tumor suppressors regulate and counterbalance the negative effects of oncogenic …

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BIOM-41. HMGB2 IS A CANDIDATE PROGNOSTIC BIOMARKER IN BOTH ADULT AND PEDIATRIC DIFFUSE GLIOMAS

Aline Paixão Becker, Valesio Becker, Zaid Sirhan, Joseph McElroy et autres

Abstract Few prognostic molecular markers are common to pediatric- and adult diffuse gliomas (PDG and ADG). HMGB2 is a protein expressed in human brain development and in de-differentiated high-grade gliomas (HGG), which we have recently described as a putative prognostic and predictive …

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Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer

Zaid Sirhan, Rawan Alojair, Anita Thyagarajan, Ravi P. Sahu

Lung cancer remains one of the major human malignancies affecting both men and women worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent type. Multiple mechanisms have been identified that favor tumor growth as well as impede the efficacy of …

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BIOL-05. IDENTIFICATION AND VALIDATION OF PA2G4 AS A POTENTIAL THERAPEUTIC TARGET IN PEDIATRIC DIFFUSE GLIOMAS

Zaid Sirhan, Blake E. Sells, Jessica L. Fleming, H. Manring et autres

Abstract Brain tumors are the second most common pediatric malignancy after leukemia. High grade gliomas have a significantly high morbidity and mortality in children, with a 5-year survival rate under 20%. This study aims to identify important biological mechanisms and proteins as …

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Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer

Aya Abunada, Zaid Sirhan, Anita Thyagarajan, Ravi P. Sahu

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) accounts for about 20% to 30% of all BC subtypes and is characterized by invasive disease and poor prognosis.With the emergence of anti-HER2 target drugs, HER2-positive BC patient outcomes have changed dramatically.However, …

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The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer

Zaid Sirhan, Anita Thyagarajan, Ravi P. Sahu

Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15-20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase kinase activity, and its overexpression is linked to poor prognosis and …

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