Accès ouvert
2014
article
OpenAlex
Monique R. Heitmeier, Ruth McCracken, Radmila Micanovic, Shehnaz Khan et autres
BACKGROUND: Tamm-Horsfall Protein (THP) is a glycoprotein expressed exclusively by cells of the thick ascending loop (TAL) of Henle. THP has a protective role in acute kidney injury (AKI), and its expression is downregulated in the early stages of injury. Tumor necrosis …
us
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Accès ouvert
2013
article
OpenAlex
Tarek M. El‐Achkar, Ruth McCracken, Yan Liu, Monique R. Heitmeier et autres
Tamm-Horsfall protein (THP) is a glycoprotein normally targeted to the apical membrane domain of the kidney's thick ascending limbs (TAL). We previously showed that THP of TAL confers protection to proximal tubules against acute kidney injury (AKI) via a possible cross talk …
us, ch
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Accès ouvert
2011
article
OpenAlex
Tarek M. El‐Achkar, Ruth McCracken, Michael Rauchman, Monique R. Heitmeier et autres
Tamm-Horsfall protein (THP) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney. We recently described a novel protective role of THP against acute kidney injury (AKI) via downregulation of inflammation in the outer medulla. Our current study investigates …
us
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Accès ouvert
2008
article
OpenAlex
Tarek M. El‐Achkar, Xue‐Ru Wu, Michael Rauchman, Ruth McCracken et autres
Tamm-Horsfall protein (THP) is a glycoprotein with unclear functions expressed exclusively in thick ascending limbs (TAL) of the kidney. Its role in ischemic acute kidney injury is uncertain, with previous data suggesting a possible negative effect by enhancing cast formation and promoting …
us, be
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2003
article
OpenAlex
Kazuaki Moridaira, Jeremiah J. Morrissey, Melanie Fitzgerald, Guangjie Guo et autres
Unilateral ureteral obstruction (UUO) is a well-established model for the study of interstitial fibrosis in the kidney. It has been shown that the renin-angiotensin system plays a central role in the progression of interstitial fibrosis. Recent studies indicate that endothelin, a powerful …
us
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2002
article
OpenAlex
Jeremiah J. Morrissey, Guangjie Guo, Kazuaki Moridaira, Melanie Fitzgerald et autres
For elucidation of the mechanisms by which growth factors and cytokines affect renal epithelial cells, gene array analysis of renal cells cultured in the presence of transforming growth factor-beta1 (TGF-beta1) was performed. Many genes that were not previously considered to be involved …
us
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2001
article
OpenAlex
Guangjie Guo, Jeremiah J. Morrissey, Ruth McCracken, Timothy Tolley et autres
Angiotensin II upregulates tumor necrosis factor-alpha (TNF-alpha) in the rat kidney with unilateral ureteral obstruction (UUO). In a mouse model of UUO, we found that tubulointerstitial fibrosis is blunted when the TNF-alpha receptor, TNFR1, is functionally knocked out. In this study, we …
it, us
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2000
article
OpenAlex
Jeremiah J. Morrissey, Guangjie Guo, Ruth McCracken, Timothy Tolley et autres
Analysis of gene expression in a mouse model of unilateral ureteral obstruction (UUO) revealed significant induction of CD14 mRNA in kidneys with obstructed ureters. Immunocytochemical analysis indicated that CD14 was upregulated in tubular epithelial cells and this upregulation was not attributable to …
us
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1999
article
OpenAlex
Guangjie Guo, Jeremiah J. Morrissey, Ruth McCracken, Timothy Tolley et autres
Unilateral ureteral obstruction (UUO) results in tubulointerstitial fibrosis of the obstructed kidney. In this study, we report the contribution of tumor necrosis factor-alpha (TNF-alpha) to the fibrosis that develops after ureteral obstruction. Mice in which individual TNF-alpha receptors TNFR1 or TNFR2 had …
us
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1998
article
OpenAlex
Hiroyuki Kaneto, Jerry Morrissey, Ruth McCracken, Álvaro Reyes et autres
Osteopontin is a bone protein also expressed in other tissues. Increased osteopontin is thought to be associated with tissue inflammation. We used immunocytochemical analyses and polymerase chain reaction amplification of mRNA to examine osteopontin expression and regulation in unilateral ureteral obstruction (UUO) …
us
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1996
article
OpenAlex
Morrissey Jj, Shigeto Ishidoya, Ruth McCracken, S Klahr
Long-term unilateral ureteral obstruction (UUO) initiates a series of renal events leading to proliferation of interstitial fibroblasts and proliferation/repair of tubular cells. This is evidenced by significant increases in proliferating cell nuclear antigen (PCNA) positive nuclei during UUO. Several pathologic settings requiring …
us
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1996
article
OpenAlex
Jeremiah J. Morrissey, Shigeto Ishidoya, Ruth McCracken, S Klahr
Angiotensin-converting enzyme (ACE) inhibitors have been shown to minimize fibrosis of the kidney tubulointerstitium in several diseases. In addition to lowering angiotensin II levels, ACE inhibitors can increase kinin levels and subsequently increase nitric oxide formation. To determine whether nitric oxide generation …
us
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