Accès ouvert
2026
article
OpenAlex
Coty Chen, Rowan Saloner, Emily W. Paolillo, Claire J. Cadwallader et autres
Background and ObjectivesPlasma growth differentiation factor 15 (GDF15), a TGFbeta family cytokine, has been robustly identified from proteomics discovery work as linked to adverse brain aging; immune dysregulation may be a core component of frontotemporal lobar degeneration (FTLD), yet biomarkers tracking immune …
us, be, ca
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Accès ouvert
2026
article
OpenAlex
Molly Olzinski, Joshua Downer, Yann Cobigo, Binita Rajbanshi et autres
Importance: TMEM106B is a frontotemporal lobar degeneration (FTLD) genetic susceptibility factor, and TMEM106B protein aggregates are a feature of aging and neurodegeneration. Whether TMEM106B protein levels are associated with clinical features is unknown. Objective: To investigate the clinical associations of cerebrospinal fluid …
us, be, gb
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Accès ouvert
2026
article
OpenAlex
Emily W. Paolillo, Amy B. Wise, JEFFREY A. KAYE, Zachary Beattie et autres
Background and Objectives: Sleep and circadian disturbances are common yet understudied in frontotemporal dementia (FTD). Advances in non-invasive digital monitoring technology enable capture of real-time objective nighttime behaviors in naturalistic settings. We examined feasibility and utility of an unobtrusive, under-the-mattress sensor to …
us
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Accès ouvert
2025
article
OpenAlex
Yara Alkhodair, Hyunwoo Lee, Ian R. Mackenzie, Emily Dwosh et autres
BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disorder marked by early impairments in executive function and altered prefrontal neural circuitry. These traits are also observed in Attention Deficit Disorder (ADD) and Attention Deficit Hyperactivity Disorder (ADHD), suggesting the possibility of shared mechanisms …
ca, us
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Accès ouvert
2025
article
OpenAlex
Sylvie Belleville, Nicole D. Anderson, Louis Bherer, Richard M. Camicioli et autres
BACKGROUND: Online educational programs focused on ways to improve brain health could increase participant literacy, empowerment, and engagement in activities that support personal brain health, potentially reducing dementia risk. OBJECTIVES: Our goal was to develop an evidence-based online educational program with a …
ca, us
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Accès ouvert
2024
article
OpenAlex
Danielle D’Amico, Marie Y. Savundranayagam, Rose Biles, Inbal Itzhak et autres
BACKGROUND: Collaborative research with end-users is an effective way to generate meaningful research applications and support greater impact on practice and knowledge exchange. To address these needs, a Citizen Advisory Group (CAG) of nine older adults (ages 64-80, 67% women) was formed …
ca, us
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2024
article
OpenAlex
Kayla Horowitz, Nellie H. Fotopoulos, Alana J. Mistry, J. A. Simó et autres
BACKGROUND: The findings of variants of uncertain significance (VUS) on a clinical genetic testing report pose a challenge for attending healthcare professionals (HCPs) in patient care. Here, we describe the outcomes of multidisciplinary VUS Rounds, implemented at a neurological disease tertiary care …
ca, br
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Accès ouvert
2024
preprint
OpenAlex
Kayla Horowitz, Nellie H. Fotopoulos, Alana J. Mistry, J. A. Simó et autres
Background: The findings of variants of uncertain significance (VUS) on a clinical genetic testing report pose a challenge for attending healthcare professionals (HCPs) in patient care. Here, we describe the outcomes of multidisciplinary VUS Rounds, implemented at a neurological disease tertiary care …
ca, br
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Khushbu J. Patel, David Yang, Howard Feldman, Ging‐Yuek Robin Hsiung et autres
Abstract INTRODUCTION We described patients’ and care partners’ experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care. METHODS IMPACT‐AD BC is an observational study of clinic patients who underwent AD CSF biomarker testing as part …
ca, us
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Accès ouvert
2023
article
OpenAlex
Sylvie Belleville, Howard Mark Chertkow, Howard Feldman, Haakon B. Nygaard et autres
Abstract Background The Intervention mapping framework was used to plan and develop Brain Health PRO (BHPro), a 45‐week, theory‐ and evidence‐based online educational program co‐created with users in English and French. The goal of the program is to improve dementia literacy, self‐efficacy, …
ca, us
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2022
article
OpenAlex
Khushbu J. Patel, David Yang, Colleen Chambers, Howard Feldman et autres
Abstract Background The growing clinical use of the analysis of CSF amyloid‐beta peptides and tau proteins to assist in the diagnosis Alzheimer’s disease (AD) highlights an urgent need to understand the impact of this testing on patients, as well as their care …
ca, us
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Accès ouvert
2021
article
OpenAlex
Julien François Bally, Ming Zhang, Emily Dwosh, Christine Sato et autres
Neurological disorders are often associated with a variety of symptoms, which can result from the combined action of genetic variants. We conducted a whole-genome analysis of a previously unreported unique multigenerational Dutch-Canadian family with a complex phenotype presenting with a combination of …
ca, ch, cn
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