Sandhya Kabra

Targeted short read NGS of HCV 5′-UTR for genotyping and identification of Sub-variants using Ion Torrent platform

Ritu Sagar, Pushpendra Singh, Mukesh Kumar Jogi, Sristy Shikha et autres

Hepatitis C Virus (HCV) is highly a mutable RNA virus, primarily due to lack of proofreading activity in RNA-dependent RNA polymerase. This intrinsic feature leads to the generation of substantial intra-host variation, resulting in the formation of viral quasispecies. The 5' untranslated …

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Validation of dried blood spot for serological diagnosis of Hepatitis B and C: a multicentric study

Arati Mane, Reshu Agarwal, Meenu Bajpai, Suvarna Sane et autres

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Understanding the mechanism of the SARS CoV-2 coinfection with other respiratory viruses

Kalaiarasan Ponnusamy, RadhaKrishnan Venkatraman Srinivasan, Robin Marwal, Meena Datta et autres

Abstract Coinfections have a potential role in increased morbidity and mortality rates during pandemics. Our investigation is aimed at evaluating the viral coinfection prevalence in COVID-19 patients. Rapid diagnostic tests are tools with a paramount impact both on improving patient care. Particularly …

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Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers

Steven A. Kemp, Mark T. K. Cheng, William L. Hamilton, Kimia Kamelian et autres

Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade …

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Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes

Ankit Kumar Pathak, Gyan Prakash Mishra, Bharathram Uppili, Safal Walia et autres

During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-CoV-2 has been useful in tracking its spread and in identifying variants of concern (VOC). Viral and host factors could contribute to variability within a host that can be captured in …

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Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

Mahesh Shanker Dhar, Robin Marwal, Radhakrishnan VS, Kalaiarasan Ponnusamy et autres

Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, …

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SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Petra Mlčochová, Steven A. Kemp, Mahesh Shanker Dhar, Guido Papa et autres

. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. …

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Genomic characterization and Epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

Mahesh Shanker Dhar, Robin Marwal, Venkatraman Radhakrishnan, Kalaiarasan Ponnusamy et autres

Abstract Delhi, the national capital of India, has experienced multiple SARS-CoV-2 outbreaks in 2020 and reached a population seropositivity of over 50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant B.1.617.2 (Delta) …

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Reinfection or reactivation: Genome‐based two distinct SNP profile of SARS‐CoV2 repositivity in an Indian case

Mahesh Shanker Dhar, A Vivekanand, Bharathram Uppili, Nishu Tyagi et autres

To date, a large number of case reports have emerged claiming COVID-19 reinfection, some confirmed by the distinct viral genotypes in each episode.1-9 This communication highlights a case report from Delhi, India, with two instances of SARS-CoV-2 where the second episode witness …

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Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes

Ankit Kumar Pathak, Gyan Prakash Mishra, Bharathram Uppili, Safal Walia et autres

ABSTRACT During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-CoV-2 has been useful in tracking its spread and in identifying Variants Of Concern (VOC). Besides, viral and host factors could contribute to variability within a host that can be …

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Exploring the conservation of epitopes in hepatitis C virus for subunit vaccine development

Varun Jaiswal, Partha Rakshit, Sandhya Kabra, Sujeet Kumar Singh

Background: Over 134 million people are estimated to be infected with Hepatitis C virus (HCV) which leads to ∼1.7 million deaths annually. In US the HCV-related death is growing from 2003 to 2013, and has exceeded 60 other nationally notifiable infectious conditions …

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A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry

Praveen Singh, Rahul Chakraborty, Robin Marwal, V. S. Radhakrishan et autres

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