Melanie Dawn Guenette

Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome

Timothy Reynold Lim, Suradech Suthiphosuwan, María Inés Gaitán, Mariano Marrodán et autres

Importance: Most people with radiologically isolated syndrome (RIS) have high proportions of white matter lesions (WMLs) demonstrating the central vein sign (ie, central vein sign-positive lesion [CVS+L]) and at least 1 paramagnetic rim lesion (PRL), representing perivenular lesion development and chronic active …

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Plasma CHI3L1 as a marker of cognitive and structural brain changes in radiologically isolated syndrome

Raphael Schneider, Koroboshka Brand-Arzamendi, Timothy Reynold Lim, Lisa Eunyoung Lee et autres

Background: Radiologically isolated syndrome (RIS) is characterised by incidental MRI findings suggestive of multiple sclerosis (MS) in individuals without typical MS symptoms. People with RIS (pwRIS) may have subtle manifestations, including cognitive impairment. We aimed to examine whether plasma chitinase 3-like 1 …

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A cross-sectional study investigating age of multiple sclerosis onset and its association with self-management knowledge and behaviors

Katherine M. Sawicka, Brian Michael Feldman, Brenda Banwell, Joseph Beyene et autres

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Choroid plexus enlargement correlates with demyelinating lesions and thalamic atrophy in radiologically isolated syndrome

Suradech Suthiphosuwan, Timothy Reynold U. Lim, Zixuan Hu, Errol Colak et autres

Background: Choroid plexus (ChP) enlargement correlates with neuroinflammation, brain atrophy, and disability in multiple sclerosis (MS); its relevance in people with radiologically isolated syndrome (pwRIS) is unclear. Objective: To investigate ChP volume (ChPvol) differences across age-/sex-matched pwRIS, people with MS (pwMS), and …

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Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis

Lisa Eunyoung Lee, Julien Cohen‐Adad, Irene M. Vavasour, Melanie Dawn Guenette et autres

OBJECTIVE: The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi-quantitative MRI measure sensitive to MS-related tissue microstructural changes, in …

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Age of multiple sclerosis symptom onset affects mental and physical health-related quality of life in opposite directions

Katherine M. Sawicka, Brian Michael Feldman, Joseph Beyene, Marcia L. Finlayson et autres

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A.1 Plasma Chitinase 3-like 1 protein levels in people with Radiologically Isolated Syndrome correlate with choroid plexus volume and subcortical grey matter atrophy

R Schneider, Koroboshka Brand‐Arzamendi, C. C. Tchoyoson Lim, Linda Lee et autres

Background: Radiologically isolated syndrome (RIS) is characterized by incidental MRI findings suggestive of multiple sclerosis in asymptomatic individuals. Emerging blood biomarkers, including neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and chitinase 3-like 1 protein (CHI3L1) are promising tools for evaluating …

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GR.2 Circulating plasma cytokines as biomarkers of inflammatory activity in radiologically isolated syndrome and Multiple Sclerosis

ST Arsenault, Koroboshka Brand‐Arzamendi, C. C. Tchoyoson Lim, Evelyn Lee et autres

Background: In multiple sclerosis (MS), soluble mediators of neuroinflammation are released by activated lymphocytes and resident immune cells, leading to demyelination and neurodegeneration. Radiologically isolated syndrome (RIS) is an entity in which white matter lesions fulfilling criteria for MS occur in individuals …

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P.017 EBNA1 titres are elevated in radiologically isolated syndrome and correlate with plasma GFAP

Emani Munasinghe, Koroboshka Brand‐Arzamendi, Travis W Lim, Lawrence Lee et autres

Background: Epstein-Barr virus (EBV) infection is believed to be a critical prerequisite for the development of multiple sclerosis (MS). This study aims to investigate whether anti-EBV titres are elevated before the onset of MS symptoms in people with radiologically isolated syndrome (pwRIS) …

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Evaluating the Therapeutic Potential of Ublituximab in the Treatment of MS: Design, Development and Place in Therapy

Sarah‐Jane Martin, Melanie Dawn Guenette, Jiwon Oh

B cells are critical to the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. B cell depletion using anti-CD20 monoclonal antibodies (mAbs) has proven to be an extremely successful treatment strategy, with profound suppression of both clinical …

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Serum Glial Fibrillary Acidic Protein as a Predictive Marker for Developing Central Vein Sign Lesions in Radiologically Isolated Syndrome (P7-6.002)

Sarah‐Jane Martin, Koroboshka Brand‐Arzamendi, Timothy Reynold U. Lim, Lisa Eunyoung Lee et autres

To investigate whether serum levels of neurofilament light protein (NfL) or glial fibrillary acidic protein (GFAP) in people with radiologically isolated syndrome (pwRIS) correlate with imaging measures associated with poor clinical outcomes in people with multiple sclerosis.

The Canadian Prospective Cohort Study to understand progression in multiple sclerosis: baseline characteristics

Jiwon Oh, Nathalie Arbour, Fabrizio Giuliani, Melanie Dawn Guenette et autres

Background: Disease progression is observed across the spectrum of people with multiple sclerosis (MS) and identification of effective treatment strategies to halt progression remains one of the greatest unmet clinical needs. Objectives: The Canadian Prospective Cohort Study to Understand Progression in MS …

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