Andreas J. Müller

Mast cells initiate lymphocyte egress from distant lymph nodes upon skin inflammation via RANKL-sphingosine-1-phosphate axis

Konstantinos Katsoulis‐Dimitriou, Waqar Umer, Laura Knop, Tanja Schickschneit et autres

Receptor activator of NFκB ligand (RANKL) is important for bone metabolism, but also modulates immune processes. We showed that mast cells (MCs) are involved in RANKL regulation, but the importance of MC-derived RANKL in skin inflammation has not yet been investigated. In …

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Engagement of S. aureus shifts the activation trajectory of neutrophils towards serial eating

Cora Schwendele, Elena A. Seiß, Jasmina Schroter, Marcel Suntrop et autres

Abstract Neutrophil recruitment and activation are essential for the control of microbial infections, yet how these cells adapt functionally upon entry into inflamed tissues remains incompletely understood. In particular, how temporal cues and direct interaction with the pathogen differentially shape neutrophil heterogeneity …

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Fibroblast-IL-7 feedback drives PDPN + monocytes to restrain CD4 + T cell responses

Yan Fu, Christophe Toussaint, Ina Sauerland, Elisabeth Reiß et autres

Summary During immune responses, pro-and anti-inflammatory mechanisms must be balanced to ensure pathogen clearance while limiting tissue damage. Monocyte-derived cells contribute to both processes, yet the underlying regulatory circuits remain incompletely defined. Here, we show that a subset of PDPN + IL-7R …

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VSI: Special Issue in honor of Claudio De Rosa on the occasion of his 65th birthday and 40 years of research activity

G. Talarico, Rocco Di Girolamo, Andreas J. Müller

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Risk factors for blood transfusion during cesarean section in women with major placenta previa

Evgeni Baev, Karin Roth, Jonas Nagel, Janine Krämer et autres

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Ingestion of mast cell granules boosts macrophages and drives atypical programming

Konstantinos Katsoulis‐Dimitriou, Julia Schmidt, Marc Röder, Jan Dudeck et autres

BACKGROUND: Macrophages exhibit high heterogeneity and plasticity, which is essential for their multifaceted roles in host defense and tissue regeneration. Mast cells (MCs) respond rapidly to injury or infection by releasing intact secretory granules, thereby initiating and potentiating innate and adaptive immunity. …

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A Study on Experimentally Induced Thrombus Formation in JAK2-V617F and Calr-del52 Mouse Models Using Ligation of the Inferior Vena Cava (IVC)

Vikas Bhuria, Martin Böttcher, Vanja Zeremski, Andreas J. Müller et autres

Introduction Arterial and venous thrombosis represent significant causes of mortality and morbidity in patients with Myeloproliferative Neoplasms (MPNs). While aberrant platelet and leukocyte activity has been identified as important cellular switchboards, the precise molecular chronology of pathologic blood coagulation in MPNs remains …

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Innate players in Th2 and non-Th2 asthma: emerging roles for the epithelial cell, mast cell, and monocyte/macrophage network

Johanna Kotrba, Ilka Müller, Alexander Pausder, Aaron Hoffmann et autres

Asthma is one of the most common chronic respiratory diseases and is characterized by airway inflammation, increased mucus production, and structural changes in the airways. Recently, there is increasing evidence that the disease is much more heterogeneous than expected, with several distinct …

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Metabolic and ionic control of T cells in asthma endotypes

Tobias J. Franz, Sabine Stegemann‐Koniszewski, Jens Schreiber, Andreas J. Müller et autres

T cells play a central role in orchestrating the immune response in asthma, with dysregulated ion channel profiles and altered metabolic signatures contributing to disease progression and severity. An important classification of asthma is based on the presence of T-helper cell type …

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Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia

Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf et autres

BACKGROUND: Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs the functions of neutrophils. METHODS: Ly6G-Cre JAK2-V617F and Ly6G-Cre CALRdel mice were generated. …

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Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes

Mangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen et autres

Gut-draining mesenteric and celiac lymph nodes (mLNs and celLNs) critically contribute to peripheral tolerance toward food and microbial antigens by supporting the de novo induction of regulatory T cells (Tregs). These tolerogenic properties of mLNs and celLNs are stably imprinted within stromal …

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Skin microbiota secretomes modulate cutaneous innate immunity against Borrelia burgdorferi s.s

Florian Baquer, B. Jaulhac, Cathy Barthel, Mariela Laura Paz et autres

In Lyme borreliosis, the skin constitutes a major interface for the host, the bacteria and the tick. Skin immunity is provided by specialized immune cells but also by the resident cells: the keratinocytes and the fibroblasts. Discoveries on the role of the …

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