Mohammad A. Alobaidy

Gut microbiota alterations and their association with tumorigenic pathways in colorectal cancer: insights from a pooled analysis of 109 microbiome datasets

Shafiul Haque, Farkad Bantun, Naif A. Jalal, Hani Faidah et autres

BACKGROUND: Colorectal cancer (CRC) is a significant global health burden, ranking amongst the top causes of cancer-associated mortality. Emerging evidences implicate gut microbiota as a prominent mediator of cell signalling, immune, and metabolic pathways in the pathophysiology of CRC. METHODS: We analysed …

ec, sa, in (code pays fourni par la source)

Exploring Novel Inhibitory Compounds Against Phosphatase Gamma 2: A Therapeutic Target for Male Contraceptives

Hashim M. Aljohani, Bayan Bokhari, Alaa M. Saleh, Areej Alyahyawi et autres

Men have limited options for contraception, despite the widely accepted public health benefits of it, placing the contraceptive burden solely on women. The current study focuses on inhibiting the PP1γ2 enzyme, which plays a role in sperm maturation and motility. The study …

sa, us (code pays fourni par la source)

Forecasting the incidence of acute lymphoid leukaemia in males and females in the Saudi population from 2020 to 2029: application of ARIMA models and public health implications

Saeed Kabrah, Budhi Handoko, Yasir Aljohani, Abdulrahman Mujalli et autres

BACKGROUND: Acute lymphoid leukaemia (ALL) is a significant cause of morbidity and mortality globally, with increasing incidence rates observed in Saudi Arabia. Despite advances in treatment, there is a lack of localized, sex-specific forecasts to guide public health interventions. OBJECTIVE: This study …

sa, id (code pays fourni par la source)

Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer

Mohammed Ali Alshehri, Hadil Alahdal, Akram Ahmed Aloqbi, Afnan Shakoori et autres

Cervical cancer, primarily caused by persistent infection with high-risk human papillomavirus strains, leads to abnormal cell growth in the cervix. Globally, it accounts for over 600,000 new cases and 340,000 deaths annually, with the highest burden in low- and middle-income countries due …

sa, ae (code pays fourni par la source)

Empagliflozin Inhibits Cadmium-Induced Hepatic Cell Apoptosis Through Endoplasmic Reticulum Stress and Autophagy Pathways

Naeem F. Qusty, Bayan Bokhari, Medhat Taha, Mohammad A. Alobaidy et autres

sa, Égypte (code pays fourni par la source)

Accuracy of Fetal Transcerebellar Diameter in Predicting Gestational Age in Singleton Pregnancies During the Second Trimester: A Cross‐Sectional Study in Sudan

Amal Elhag, Mohammad A. Alobaidy, Dalia Adam, E. Abdalla et autres

BACKGROUND: Pregnancy dating in the second trimester is particularly crucial for maternal and fetal health in developing countries, such as Sudan, where women may present as late as the second trimester at the first antenatal visit. This study aimed to assess the …

sa, Soudan (code pays fourni par la source)

Polydatin Mitigates Lead-Induced Nephropathy by Modulating Oxidative Stress, Inflammation, and the AMPK/AKT/Nrf2 Pathway in Rats

Naief Dahran, Mohammad A. Alobaidy, Wejdan H. Owaydhah, Ehdaa K. A. Soubahi et autres

sa, Égypte (code pays fourni par la source)

Ameliorative Effect of N-Acetylcysteine Against 5-Fluorouracil-Induced Cardiotoxicity via Targeting TLR4/NF-κB and Nrf2/HO-1 Pathways

Omer Abdelbagi, Medhat Taha, Abdullah G. Al-Kushi, Mohammad A. Alobaidy et autres

Background and Objectives: 5-Fluorouracil (5-FU) is a widely prescribed and effective chemotherapeutic drug, but its cardiotoxic side effects pose a significant challenge to its use. Identifying a protective agent that does not affect its anticancer efficacy is essential. Our study aimed to …

sa, Égypte (code pays fourni par la source)

Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction‐associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways

Wesam F. Farrash, Shakir Idris, Mohamed Elzubier, Elshiekh B. Khidir et autres

Abstract Although single treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) or vitamin D3 (VD3) inhibited metabolic dysfunction‐associated steatohepatitis (MASH) development in diabetic patients, their combination has not been explored previously. Hence, this study investigated the hepatoprotective effects of SGLT2i (empagliflozin) and/or VD3 against …

sa, Égypte (code pays fourni par la source)

Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of pharmacokinetic properties prediction of ADME

Afnan Shakoori, Zain Alhindi, Mohammad A. Alobaidy, Amna Moulana et autres

BACKGROUND OBJECTIVES: Quantum chemical and molecular docking practices deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 ( Plasmodium falciparum 3D7). Further, pharmacokinetics of a drug candidate which is influenced by a variety of factors, …

sa (code pays fourni par la source)

Comparative Validation Study between Pneumatic Tube System and Hand Carried Blood Sample

Amna Moulana, Alya Almatrafi, Riyazuddin Ansari, Asim Khogeer et autres

Rapid delivery of specimens is crucial in today's clinical laboratories, and pneumatic tube systems are commonly utilized for this purpose. The validation of sample stability through pneumatic tube system (PTS) is essential. The use of Pneumatic Tube System can improve specimen turnaround …

sa, us (code pays fourni par la source)

Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus

Abdulrahman Mujalli, Wesam F. Farrash, Ahmad A. Obaid, Anmar A. Khan et autres

Herein, we measured the antidiabetic and nephroprotective effects of the sodium–glucose cotransporter-2 inhibitor (empagliflozin; SGLT2i) and synthetic active vitamin D (paricalcitol; Pcal) mono- and co-therapy against diabetic nephropathy (DN). Fifty mice were assigned into negative (NC) and positive (PC) control, SGLT2i, Pcal, …

sa (code pays fourni par la source)