Necat Havlioglu

Proteomics data for 'How Does Tendon Region, Donor, and the Presence of Disease Affect Protein Composition of the Achilles Tendon?'

Rachana Vaidya, Petra E. Gilmore, Qiang Zhang, Xing Jian et autres

Proteomics data from Achilles tendon specimens from human patients undergoing surgery for lower extremity amputation (n=10; 5 with diabetes, 5 non-diabetes controls) or Achilles tendon debridement/repair for Achilles tendinopathy (n=10). The collection of this data was conducted with the approval of the …

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Anti-Inflammatory Treatment and Active Physical Therapy Have Differing Effects on Functional, Mechanical, and Histological Properties in a Rat Model of Post-Traumatic Elbow Contracture

Rebecca F. Reals, Ryan M. Castile, Evan Bradley, A. Movva et autres

Post-traumatic joint contracture (PTJC) frequently occurs in the elbow after injury, decreasing range of motion (ROM) and causing dysfunction. Physical therapy improves ROM but does not address underlying inflammation and fibrosis. Combining physical exercise with biological treatment has shown positive results in …

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Flow cytometric identification of dynamic immune cell populations in a rat model of post-traumatic elbow contracture

Rebecca F. Reals, J. Caleb Snider, Ryan M. Castile, Chelsey L. Dunham et autres

PURPOSE/AIM: Post-traumatic joint contracture (PTJC) commonly occurs after elbow injury. Previous findings implied immune system activation in capsules of contracted joints; however, quantifying immune cell populations in rodent joint tissues is challenging due to small size and low cellularity. Here, we used …

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S4766 Gastric Intestinal Metaplasia of Duodenum With Subsequent Development of Duodenal Adenoma: An Opportunity for Endoscopic Vigilance

Amlish Gondal, Aftab Sharif, Umer Farooq, Necat Havlioglu et autres

Introduction: Sporadic non-ampullary duodenal adenomas are detected in patients without familial adenomatous polyposis syndrome with increasing endoscopic visualization. However, progression from duodenal gastric metaplasia remains exceedingly rare with literature reviews suggesting few case reports. Case Description/Methods: A 49-year-old woman presented with epigastric …

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The effects of NF‐κB suppression on the early healing response following intrasynovial tendon repair in a canine model

Ryan A. Lane, Nicole Migotsky, Necat Havlioglu, Leanne E. Iannucci et autres

The highly variable clinical outcomes noted after intrasynovial tendon repair have been associated with an early inflammatory response leading to the development of fibrovascular adhesions. Prior efforts to broadly suppress this inflammatory response have been largely unsuccessful. Recent studies have shown that …

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Early Joint Use Following Elbow Dislocation Limits Range-of-Motion Loss and Tissue Pathology in Posttraumatic Joint Contracture

Alex J. Reiter, Hayden R. Schott, Ryan M. Castile, Paul C. Cannon et autres

BACKGROUND: Simple elbow dislocation occurs at an incidence of 2.9 to 5.21 dislocations per 100,000 person-years, with as many as 62% of these patients experiencing long-term elbow joint contracture, stiffness, and/or pain. Poor outcomes and the need for secondary surgical intervention can …

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Segmental Colitis Associated With Diverticulosis Masquerading as Polyploid-Appearing Mucosa in the Rectosigmoid Area on Endoscopy and as Focal Thickening on Imaging

Eugene Nwankwo, Gebran Khneizer, Gregory S. Sayuk, Jill E. Elwing et autres

Segmental colitis associated with diverticulosis (SCAD) is an inflammatory disease affecting segments of the large bowel with diverticular disease. SCAD presents several challenges in diagnoses and treatment because it often mimics a range of disorders including inflammatory bowel disease and malignancy. Here, …

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Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture

Michael A. David, Alex J. Reiter, Chelsey L. Dunham, Ryan M. Castile et autres

Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered …

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Females and males exhibit similar functional, mechanical, and morphological outcomes in a rat model of posttraumatic elbow contracture

Alex J. Reiter, Hayden R. Schott, Ryan M. Castile, Paul C. Cannon et autres

Posttraumatic joint contracture (PTJC) is a debilitating condition characterized by loss of joint motion following injury. Previous work in a rat model of elbow PTJC investigated disease etiology, progression, and recovery in only male animals; this study explored sex-based differences. Rat elbows …

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Adipose stem cells exhibit mechanical memory and reduce fibrotic contracture in a rat elbow injury model

Chelsey L. Dunham, Necat Havlioglu, Aaron M. Chamberlain, Spencer P. Lake et autres

Fibrosis is driven by a misdirected cell response causing the overproduction of extracellular matrix and tissue dysfunction. Numerous pharmacological strategies have attempted to prevent fibrosis but have attained limited efficacy with some detrimental side effects. While stem cell treatments have provided more …

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Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats

Zurab Kakabadze, Lia Karalashvili, David Chakhunashvili, Necat Havlioglu et autres

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Temporal Patterns of Motion in Flexion-extension and Pronation-supination in a Rat Model of Posttraumatic Elbow Contracture

Chelsey L. Dunham, Ryan M. Castile, Necat Havlioglu, Aaron M. Chamberlain et autres

BACKGROUND: The elbow is highly susceptible to contracture, which affects up to 50% of patients who experience elbow trauma. Previously, we developed a rat model to study elbow contracture that exhibited features similar to the human condition, including persistently decreased ROM and …

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