Melanie K. Saville

Standing the test of COVID-19: charting the new frontiers of medicine

Simon Cauchemez, Giulio Cossu, Nathalie M. Delzenne, Eran Elinav et autres

The COVID-19 pandemic accelerated research and innovation across numerous fields of medicine. It emphasized how disease concepts must reflect dynamic and heterogeneous interrelationships between physical characteristics, genetics, co-morbidities, environmental exposures, and socioeconomic determinants of health throughout life. This article explores how scientists …

fr, de, gb, it, be, il, us, nl, ca (code pays fourni par la source)

Factors, enablers and challenges for COVID-19 vaccine development

Jean‐Louis Excler, Melanie K. Saville, Lois A. Privor-Dumm, Sarah E. Gilbert et autres

The COVID-19 pandemic triggered a sense of vulnerability and urgency that led to concerted actions by governments, funders, regulators and industry to overcome traditional challenges for the development of vaccine candidates and to reach authorisation. Unprecedented financial investments, massive demand, accelerated clinical …

kr, us, gb, qa (code pays fourni par la source)

COVID-19 vaccines and the pandemic: lessons learnt for other neglected diseases and future threats

Peter Jay Hotez, Sarah C. Gilbert, Melanie K. Saville, Lois A. Privor-Dumm et autres

Through the experiences gained by accelerating new vaccines for both Ebola virus infection and COVID-19 in a public health emergency, vaccine development has benefited from a 'multiple shots on goal' approach to new vaccine targets. This approach embraces simultaneous development of candidates …

us, gb, no, Afrique du Sud, kr (code pays fourni par la source)

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy

Tabitha Leighton, Julie Ostrowsky, Cory Alec Manzo Anderson, Richard Danila et autres

Broadly protective coronavirus vaccines are an important tool for protecting against future SARS-CoV-2 variants and could play a critical role in mitigating the impact of future outbreaks or pandemics caused by novel coronaviruses. The Coronavirus Vaccines Research and Development (R&D) Roadmap (CVR) …

us, Afrique du Sud, gb (code pays fourni par la source)

Delivering Pandemic Vaccines in 100 Days — What Will It Take?

Melanie K. Saville, Jakob P. Cramer, M. A. P. S. Downham, Adam Hacker et autres

no, us (code pays fourni par la source)

Meeting report: CEPI consultation on accelerating access to novel vaccines against emerging infectious diseases for pregnant and lactating women, London, 12–13 February 2020

Gérald Voss, Jeanne‐Marie Jacquet, Nadia Tornieporth, Beate Kampmann et autres

no, gb, us, Ghana (code pays fourni par la source)

COVID-19: release approved vaccines for trials of new ones

Melanie K. Saville

IABS/CEPI platform technology webinar: Is it possible to reduce the vaccine development time?

Joris Vandeputte, Melanie K. Saville, Marco Cavaleri, Martin Friede et autres

The International Alliance for Biological Standardization and the Coalition for Epidemic Preparedness Innovations organized a joint webinar on the use of platform technologies for vaccine development. To tackle new emerging infectious diseases, including SARS-CoV-2, rapid response platforms, using the same basic components …

ch, no, nl, de, ca, dk (code pays fourni par la source)

Vaccine development for emerging infectious diseases

Jean‐Louis Excler, Melanie K. Saville, Seth Berkley, Jérôme H. Kim

kr, ch (code pays fourni par la source)

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries

Moses Badio, Édouard Lhomme, Mark Kieh, Abdoul Habib Béavogui et autres

INTRODUCTION: The Ebola virus disease (EVD) outbreak in 2014-2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine. Multiple questions regarding the safety, immunogenicity, …

Libéria, fr, Mali, Sierra Leone, us, gb (code pays fourni par la source)

Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemic

Marc F.D. Baay, Bruno Lina, Arnaud L Fontanet, Arnaud Marchant et autres

This International Alliance for Biological Standardization COVID-19 webinar was organized to provide an update on the virology, epidemiology and immunology of, and the vaccine development for SARS-CoV-2, none months after COVID-19 was declared a public health emergency of international concern. It brought …

fr, be, no, ch (code pays fourni par la source)

Nipah@20: Lessons Learned from Another Virus with Pandemic Potential

Raúl Gómez Román, Lin‐Fa Wang, Benhur Lee, Kim Halpin et autres

Nipah disease is listed as one of the WHO priority diseases that pose the greatest public health risk due to their epidemic potential. More than 200 experts from around the world convened in Singapore last year to mark the 20th anniversary of …

no, sg, us, au, bd (code pays fourni par la source)