Janelle M. Haider

Alzheimer Disease and Cancer

Ayesha Z. Sherzai, Melvin Parasram, Janelle M. Haider, Dean Sherzai

INTRODUCTION: Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer. This inverse relationship was further explored. In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes. The relationship of Pin1 expression in 10 …

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Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care

Liana G. Apostolova, Janelle M. Haider, Naira Goukasian, Gil D. Rabinovici et autres

Abstract Introduction The utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established. Methods Fifty‐three cognitively impaired patients with clinical F18‐florbetapir imaging were classified as early and late onset, as well as AUC‐consistent or AUC‐inconsistent. Chi‐square statistics and t …

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Critical review of the Appropriate Use Criteria for amyloid imaging: Effect on diagnosis and patient care.

Liana G. Apostolova, Janelle M. Haider, Naira Goukasian, Gil D. Rabinovici et autres

IntroductionThe utility of the Appropriate Use Criteria (AUC) for amyloid imaging is not established.MethodsFifty-three cognitively impaired patients with clinical F18-florbetapir imaging were classified as early and late onset, as well as AUC-consistent or AUC-inconsistent. Chi-square statistics and t test were used to …

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Amyloid-β 11 C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

Enchi Liu, Mark E. Schmidt, Richard A. Margolin, Reisa Anne Sperling et autres

OBJECTIVE: To evaluate the effects of bapineuzumab on brain β-amyloid (Aβ) burden using (11)C-Pittsburgh compound B ((11)C-PiB)-PET. METHODS: Two phase 3 clinical trials, 1 each in apolipoprotein APOE ε4 carriers and noncarriers, were conducted in patients with mild to moderate Alzheimer disease …

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IC‐P‐018: Critical appraisal of the appropriate use criteria: Effect on diagnosis and patient care

Liana G. Apostolova, Janelle M. Haider, Naira Goukasian, Holly LeClair et autres

In 2013 the Amyloid Imaging Task Force developed the Appropriate Use Criteria (Auc) for clinical use of amyloid PET imaging. The AUC utility remains to be empirically tested. Fifty-three patients underwent F-Florbetapir scanning at UCLA as part of their individualized diagnostic work …

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P1‐154: Critical appraisal of the appropriate use criteria: Effect on diagnosis and patient care

Liana G. Apostolova, Janelle M. Haider, Naira Goukasian, Holly LeClair et autres

In 2013 the Amyloid Imaging Task Force developed the Appropriate Use Criteria (Auc) for clinical use of amyloid PET imaging. The Auc utility remains to be empirically tested. Fifty-three patients underwent F-Florbetapir scanning at UCLA as part of their individualized diagnostic work …

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Constipation is reduced by beta-blockers and increased by dopaminergic medications in Parkinson's disease

Gennaro Pagano, Echo E. Tan, Janelle M. Haider, Alyssa E. Bautista et autres

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Cognitive Performance after Lacunar Stroke Correlates with Leukoaraiosis Severity

Aaron M. McMurtray, Alex Chien-Hwa Liao, Janelle M. Haider, Eliot A. Licht et autres

BACKGROUND: This study investigates the effect of leukoaraiosis on patients presenting with cognitive impairment after lacunar stroke. METHODS: Fourty-six patients with cognitive impairment and newly discovered lacunar stroke detected by brain magnetic resonance imaging underwent neuropsychological testing. RESULTS: Patients with both lacunar …

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Vulnerability of the Anterior Commissure in Moderate to Severe Pediatric Traumatic Brain Injury

Elisabeth A. Wilde, Erin D. Bigler, Janelle M. Haider, Zili David Chu et autres

In relation to the adult brain, the immature brain might be more vulnerable to damage during and following traumatic brain injury, particularly in white-matter tracts. Given well-established evidence of corpus callosum atrophy, we hypothesized that anterior commissure volume (using quantitative magnetic resonance …

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Increased incidence of cardiotoxicity after infusional 5-fluorouracil, cisplatin and docetaxel combination chemotherapy in patients with locally advanced head and neck cancer

Agnes Smáradóttir, Aiman Siddiqi, Carolyn M. Ray, Janelle M. Haider et autres

5568 Background: Infusional 5 fluorouracil (5FU) combination with cisplatin remain the most active regimen in previously untreated patients with locally advanced head and neck cancer. Recent combination of this regimen with taxanes have further improved the overall responses suggesting its potential for …

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