Everett G. Seay

Physiologic mechanisms of response to hypoglossal nerve stimulation

Linda C. Magaña, Yash Dixit, Bruno Saconi, Brendan T Keenan et autres

STUDY OBJECTIVES: To evaluate the relationship between physiologic mechanisms under drug-induced sleep endoscopy (DISE) and polysomnographic response to hypoglossal nerve stimulation (HGNS). MATERIALS AND METHODS: In an NIH-funded interventional trial, thirty subjects with HGNS devices underwent DISE with pneumotachometer, pharyngeal manometry, and …

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Translating hypoglossal nerve stimulation tongue movement into functional response during drug-induced sleep endoscopy: a proof-of-concept study

Tice R. Harkins, Everett G. Seay, Eric Rodrigues Thuler, Raj C. Dedhia

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The Association of Upper Airway Anatomy and Hypoglossal Nerve Stimulation Response in OSA

Chau Phung, Tice R. Harkins, Linda C. Magaña, Yash Dixit et autres

OBJECTIVES: Hypoglossal nerve stimulation (HGNS) is a promising surgical treatment of obstructive sleep apnea (OSA) for patients intolerant to positive airway pressure (PAP). Nonetheless, more than one-third of patients have suboptimal outcomes, demonstrating the need for improved understanding of factors associated with …

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Ascending and Descending Pharyngeal Opening Pressures During Drug‐Induced Sleep Endoscopy: Mechanistic Insights for Sleep Surgeons

Linda C. Magaña, Tice R. Harkins, Andrew S. Wiemken, Brendan T Keenan et autres

Abstract Objective To assess whether differences exist between ascending pharyngeal opening pressure (PhOPA) and descending pharyngeal opening pressure (PhOPD) obtained from positive airway pressure (PAP) titrations during drug‐induced sleep endoscopy (DISE) and to identify the associations between the physiologic and anatomic constituents …

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The Prevalence of Central Sleep Apnea in New Referrals to a Sleep Surgery Clinic

Julianna G. Rodin, Tice R. Harkins, Erica R Kent, Chau Phung et autres

OBJECTIVE: Surgical treatment of non-obstructive sleep apnea (OSA) pathology poses the risk of inappropriate surgical indications. Herein, we sought to determine the prevalence of non-OSA respiratory disorders, specifically central sleep apnea (CSA), in new referrals to a Sleep Surgery Clinic. STUDY DESIGN: …

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Complete Palatal Obstruction on Drug-Induced Sleep Endoscopy: Just Mouth Breathing?

Tice R. Harkins, Julianna G. Rodin, Chau Phung, Everett G. Seay et autres

A 70-year-old obese male with moderate obstructive sleep apnea (OSA) sought alternative treatment after failing to tolerate positive airway pressure (PAP) therapy. He underwent drug-induced sleep endoscopy (DISE) with a nasal cannula and oral thermistor to differentiate nasal from oral breathing and …

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The 5 faces of flow in asynchronous hypoglossal nerve stimulation

Tice R. Harkins, Leonard Jie Min Soh, Everett G. Seay, Eric Rodrigues Thuler et autres

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Pharyngeal Manometry and Upper Airway Collapse During Drug-Induced Sleep Endoscopy

Tice R. Harkins, Akshay Tangutur, Brendan T Keenan, Everett G. Seay et autres

Importance: Drug-induced sleep endoscopy (DISE) is used to guide therapeutic management of obstructive sleep apnea (OSA), depending on the levels and patterns of pharyngeal collapse. However, the collapsibility of specific pharyngeal sites remains unknown. Objective: To assess collapse sites in patients with …

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Physiologic and anatomic determinants of hyoid motion during drug-induced sleep endoscopy

Manan H. Parekh, Eric Rodrigues Thuler, Vasiliki Triantafillou, Everett G. Seay et autres

PURPOSE: To examine factors accounting for differences in hyoid motion during obstructive breathing events amongst obstructive sleep apnea (OSA) patients. METHODS: This was a prospective cohort study from June 2022 to October 2022. Patients with OSA undergoing evaluation for PAP alternative therapies …

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Mechanistic insights from sleep endoscopy related to oronasal mask failures: a case report

Tice R. Harkins, Everett G. Seay, Alan R. Schwartz, Eric Rodrigues Thuler et autres

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The Whimsical Nature of Airway Obstruction during Drug‐Induced Sleep Endoscopy

Tice R. Harkins, Vasiliki Triantafillou, Everett G. Seay, Alan R. Schwartz et autres

A 47-year-old male patient diagnosed with severe obstructive sleep apnea (OSA) sought alternatives to positive airway pressure, prompting evaluation with drug-induced sleep endoscopy (DISE). He underwent a specialized DISE with nasal airflow and pharyngeal pressure monitoring. During obstructive apneas, airflow and pressure …

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Association Between Soft Tissue Measures From Computed Tomography and Upper Airway Collapsibility on Drug‐Induced Sleep Endoscopy

Eric Rodrigues Thuler, Manan H. Parekh, Jules G. Rodin, Everett G. Seay et autres

Abstract Objective Positive airway pressure (PAP) titration during drug‐induced sleep endoscopy (DISE) provides objective measures of upper airway collapsibility. While skeletal measurements relate to collapsibility measures on DISE, the influence of soft tissue dimensions on upper airway collapsibility is not known. We …

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