Joanna Kufel-Grabowska

Pituitary carcinoma: a diagnostic labyrinth in a rare endocrinopathy

Julia Anita Tarnowska, Filip Szydzik, Bartosz Żegleń, Ewa Zalewska et autres

pl (code pays fourni par la source)

Prospects for implementing the European Code of Cancer Practice: Lessons from Poland

Joanna Kufel-Grabowska, Jacek Jassem

pl (code pays fourni par la source)

Out-of-pocket (OOP) costs incurred by breast cancer patients in Poland

Mikołaj Bartoszkiewicz, Joanna Kufel-Grabowska, Zsuzsanna Beretzky, Péter György Balázs et autres

Introduction. Breast cancer is the most frequently diagnosed malignant tumor in women worldwide, the treatment of which, despite being financed by public systems, generates significant costs borne directly by patients. Aim: The study aimed to analyze out-of-pocket (OOP) costs incurred by breast …

pl, hu (code pays fourni par la source)

Experts’ position paper on the diagnostics of the PI3K–AKT–mTOR signaling pathway in hormone-dependent breast cancer

B. Radecka, Małgorzata Stawicka-Niełacna, Małgorzata Oczko-Wojciechowska, Artur Kowalik et autres

Szlak PI3K–AKT–mTOR reguluje wzrost, przeżycie i metabolizm komórek. Jego nadmierna aktywacja jest jednym z kluczowych mechanizmów rozwoju i progresji raka piersi, zwłaszcza podtypu HR+/HER2–, oraz istotnym czynnikiem powstawania hormonooporności podczas leczenia hormonalnego. Najważniejsze istot­ne klinicznie zmiany obejmują zaburzenia w genach PIK3CA, AKT1 …

Basket trial designs in oncology: A comprehensive systematic review

Mikołaj Bartoszkiewicz, Joanna Kufel-Grabowska, Paweł Burchardt

BACKGROUND: Basket trials are an innovative type of clinical trial primarily used in oncology. A distinctive feature of these studies is the grouping of patients based on specific molecular characteristics, such as genetic mutations or immunological subtypes, rather than traditional criteria like …

pl (code pays fourni par la source)

The impact of neoadjuvant chemotherapy (NAC) ± anti-HER2 antibodies (mAbs) on gut microbiome composition in early breast cancer (EBC): A pilot prospective study.

Renata Duchnowska, Bartosz Szymanowski, Joanna Kufel-Grabowska, Karolina Kaźmierczak-Siedlecka et autres

e12626 Background: Gut microbiome composition and its changes induced by chemotherapy ± anti-HER2 monoclonal antibodies (mAbs) in breast cancer patients are poorly recognized. We assessed gut microbiome composition before and after NAC ± anti-HER2 mAbs in early breast cancer (EBC). Methods: Stool …

pl (code pays fourni par la source)

420P Physicians’ knowledge, practice and attitudes on fertility and pregnancy-related issues in young women with advanced breast cancer: Results of the ABC6 and ABC7 survey

Simone Nardin, Luca Arecco, Virginia Delucchi, E. Blondeaux et autres

Fertility and pregnancy-related issues are critical for young patients with breast cancer. Very limited evidence exists on physicians' knowledge, practice and attitudes on dealing with these concerns in the specific group of patients with advanced disease.

be, it, br, vn, il, us, pl (code pays fourni par la source)

290P Challenges in breast cancer prevention awareness: Identifying gaps among medical trainees

Peter G. Kalman, Jakub Czarny, K. Pietroniec, N. Siwak et autres

Breast cancer is the most common malignancy among women, making prevention and early detection key to reducing mortality. This study examines the attitudes and experiences of students in healthcare disciplines regarding breast cancer prevention, with a focus on clinical breast examination (CBE) …

pl, hu (code pays fourni par la source)

Umbrella trials as a novel concept of cancer clinical trials — a systematic review

Mikołaj Bartoszkiewicz, Joanna Kufel-Grabowska, Paweł Burchardt

Precision medicine in oncology is a strategy for selecting cancer patients with specific molecular disorders that may be suitable for targeted therapies at the cellular level. With the development of targeted therapies, pharmaceutical companies emphasize the importance of molecular clinical trials in …

pl (code pays fourni par la source)

Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the PREFERABLE-EFFECT Randomized Controlled Trial

Aniek E.M. Schouten, Anouk E. Hiensch, Geert Frederix, Evelyn M. Monninkhof et autres

PURPOSE: To evaluate the cost utility of a 9-month supervised exercise program for patients with metastatic breast cancer (mBC), compared with control (usual care, supplemented with general activity advice and an activity tracker). Evidence on the cost-effectiveness of exercise for patients with …

nl, de, es, au, se, ch, pl (code pays fourni par la source)

Characteristics and clinical outcomes of breast cancer in young BRCA carriers according to tumor histology

Elisa Agostinetto, Marco Bruzzone, Anne‐Sophie Hamy, Hyo Jung Kim et autres

BACKGROUND: Young women with breast cancer (BC) have an increased chance of carrying germline BRCA pathogenic variants (PVs). Limited data exist on the prognostic impact of tumor histology (i.e. ductal versus lobular) in hereditary breast cancer. METHODS: This multicenter retrospective cohort study …

be, it, fr, kr, il, nl, pl, in, us, au, ca, se, mx, lb, rs (code pays fourni par la source)

Diagnostics and treatment of BRCA-associated cancers with olaparib — expert position statement

Artur Kowalik, Anita Monika Chudecka-Glaz, Joanna Kufel-Grabowska, Iwona Skoneczna et autres

Protein products of the BRCA1 and BRCA2 genes play a key role in DNA repair processes carried out by homologous recombination. Maintaining the correct double-stranded DNA structure is important for genome stability and preventing cancer transformation, including uncontrolled proliferation of tumor cells. …

pl (code pays fourni par la source)