Gavin M. Sowa

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis

Ahmed Abdelhak, Gabriel Cerono, Fahime Sheikhzadeh, Adil Harroud et autres

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An autoantibody signature predictive for multiple sclerosis

Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar et autres

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Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape

Isobel A. Hawes, Bonny D. Alvarenga, William T. Browne, Anne E. Wapniarski et autres

Antiretroviral therapy (ART) suppresses plasma and cerebrospinal fluid (CSF) HIV replication. Neurosymptomatic (NS) CSF escape is a rare exception in which CNS HIV replication occurs in the setting of neurologic impairment. The origins of NS escape are not fully understood. We performed …

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A Predictive Autoantibody Signature in Multiple Sclerosis

Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar et autres

Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of …

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Unbiased serology reveals autoimmunity and HIV antibody signatures in HIV CNS Escape

Isobel A. Hawes, Bonny D. Alvarenga, William T. Browne, Anne E. Wapniarski et autres

Abstract Background Antiretroviral therapy (ART) suppresses plasma and cerebrospinal fluid (CSF) HIV replication with occasional asymptomatic episodes of detectable HIV RNA known as asymptomatic (AS) escape. Neurosymptomatic (NS) CSF escape is a rare exception in which CNS HIV replication occurs in the …

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Pathogen and Antibody Identification in Children with Encephalitis in Myanmar

Maria M. Galardi, Gavin M. Sowa, Cameron D. Crockett, Robert Rudock et autres

OBJECTIVE: Prospective studies of encephalitis are rare in regions where encephalitis is prevalent, such as low middle-income Southeast Asian countries. We compared the diagnostic yield of local and advanced tests in cases of pediatric encephalitis in Myanmar. METHODS: Children with suspected subacute …

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Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Sara E. Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F. Kung et autres

Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-seq for autoantigen discovery, including …

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Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

Sara E. Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F. Kung et autres

A high-throughput extension of PhIP-seq reveals novel antigen specificities leading to new insights across multiple human autoimmune and inflammatory diseases, enables application of machine learning approaches to PhIP-seq datasets, and highlights the importance of controlled PhIP-seq cohorts.

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Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

Sara E. Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F. Kung et autres

Phage Immunoprecipitation-Sequencing (PhIP-Seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-Seq for autoantigen discovery, including our …

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Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

Ryan D. Schubert, Isobel A. Hawes, Prashanth Ramachandran, Akshaya Ramesh et autres

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ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A Mann et autres

Comprehensive understanding of the serological response to SARS-CoV-2 infection is important for both pathophysiologic insight and diagnostic development. Here, we generate a pan-human coronavirus programmable phage display assay to perform proteome-wide profiling of coronavirus antigens enriched by 98 COVID-19 patient sera. Next, …

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ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A Mann et autres

Serologic assays are needed to determine SARS-CoV-2 seroprevalence, but poor specificity can overestimate exposures. Here, we built a pan-human coronavirus proteome-wide programmable phage display assay (VirScan) to profile coronavirus antigens specifically enriched by 20 COVID-19 patient serum IgG. With ReScan, a new …

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