2026
conference-abstract
OpenAlex
Kyle J. Seamon, Jingwei Yin, Ouma Onguka, Oliver Lai et autres
Abstract RAS family proteins regulate cell growth by transitioning between GTP-bound (ON) and GDP-bound (OFF) conformations. Transition to the OFF state is facilitated by endogenous GTPase activating proteins (GAPs). Oncogenic mutations in RAS - among the most prevalent genetic events in human …
us
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2022
conference-abstract
OpenAlex
Elena S. Koltun, Meghan A. Rice, William Clay Gustafson, David Wilds et autres
Abstract Mutant RAS is common in pancreatic carcinoma (PDAC), non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) and exists predominantly in the GTP-bound (RAS(ON)) state, leading to excessive downstream oncogenic signaling. KRASG12C(OFF) inhibitors have provided clinical proof of concept for targeting …
us
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2018
conference-abstract
OpenAlex
Elena S. Koltun, Naing Aay, Andreas Buckl, Ashutosh S. Jogalekar et autres
Abstract Genetic and pharmacologic evidence has shown that SHP2, a non-receptor protein tyrosine phosphatase (PTP) and scaffold protein encoded by the PTPN11 gene, is a convergent signal transduction node that integrates growth factor signals from multiple receptors to promote activation of RAS …
us
(code pays fourni par la source)