A Seber

Prophylaxis of graft-versus-host-disease: Systematic evidence-based recommendations of the Brazilian association of hematology, hemotherapy, and cell therapy (ABHH) and the Brazilian society of cellular therapy and bone marrow transplantation (SBTMO)

Afonso Celso Vigorito, Carmino A. de Souza, N Hamerschlak, Vaneuza A.M. Funke et autres

Graft-versus-host disease, involving from 20%-80% of patients, is one of the main complications of allogeneic hematopoietic cell transplantation contributing significantly to mortality and morbidity. The methodological basis of these graft-versus-host disease prophylaxis guidelines for allogeneic hematopoietic cell transplantation, developed by the Brazilian …

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High-dose chemotherapy with autologous stem cell rescue in children under 5 years of age with central nervous system embryonal tumors: results from a prospective cohort in an upper-middle-income country

Andréa Maria Cappellano, Natália Dassi, Francine Tesser Gamba, Victor Gottardello Zecchin et autres

PURPOSE: High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been employed to mitigate the long-term side effects of radiotherapy and improve survival outcomes in infants with embryonal central nervous system (CNS) tumors. METHODS: This prospective study, supported by federal funding …

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ID #396 High-Dose Chemotherapy with Autologous Stem Cell Rescue in Children under 5 Years of Age with Central Nervous System Embryonal Tumors: Results from a Prospective Middle-Income Country Cohort

Andrea M Cappellano, Natalia Dassi, Jessica Rodrigues, A Seber et autres

Abstract High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been employed to mitigate long-term side effects of radiotherapy (RT) and improve survival of central nervous system (CNS) embryonal tumors in infants. Objective Characterize a cohort of patients treated with a …

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Haploidentical Versus HLA-matched Unrelated Donors for Hematopoietic Cell Transplantation in Acute Leukemia: A Multicenter Observational Study in a Developing Country Facilitated by Collaboration Between the CIBMTR and the Brazilian Society of Cellular Therapy and Bone Marrow Transplantation (SBTMO)

Mariana Nassif Kerbauy, Leonardo Javier Arcuri, Vergílio Antônio Rensi Colturato, Mair Pedro de Souza et autres

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Comparison of Carmustine-, Lomustine-, and Nitrosourea-Free Conditioning Regimens for Autologous HCT (Auto-HCT) in Lymphoma: Results From the Hematopoietic Cell Transplantation Brazilian Registry (HCTBR)

Abrahão Elias Hallack Neto, Vanderson Rocha, EC Miranda, Fernando B Duarte et autres

None.

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Post-transplant cyclophosphamide-based graft-versus-host disease prophylaxis and its impact on allogeneic hematopoietic cell transplantation donor selection: A summary of the SBTMO/ABHI joint session at the 2025 SBTMO annual meeting

Alberto Cardoso Martins Lima, Antonio Martin Jimenez-Jimenez, Celso Arrais Rodrigues da Silva, A Seber et autres

This brief communication summarizes the joint session of the Brazilian Cellular Therapy and Bone Marrow Transplantation Society (SBTMO) and the Brazilian Histocompatibility and Immunogenetics Association (ABHI), held during the 2025 SBTMO Annual Meeting. The joint session focused on how post-transplant cyclophosphamide (PTCy) …

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Consensus in stem cell transplantation for pediatric solid tumors

Cilmara Kuwahara, Simone Castro Resende Franco, Luiza Milaré, Cláudio Galvão de Castro Junior et autres

Solid tumors in the pediatric population are preferred treated in clinical national or international protocols, in which the work of pediatric oncology cooperative groups guides the therapeutic standards and advancements. The role of high-dose chemotherapy (HDC) and hematopoietic cell transplant (HCT) in …

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Donor leucocyte infusion

Adriana Martins de Sousa, Rita de Cassia Barbosa Tavares, Gil Cunha De Santis, A Seber

Donor-derived cellular therapies play a pivotal role in optimizing outcomes after allogeneic hematopoietic stem-cell transplantation (HCT). This article reviews three key post-transplant interventions: donor lymphocyte infusion (DLI), hematopoietic stem-cell boost, and mesenchymal stromal cell (MSC) infusion. DLI remains a cornerstone strategy for …

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Hematopoietic stem cell transplantation for neuroblastoma

Carla Nolasco Monteiro Breviglieri, Nathalia da Silva Halley Neves, Mariana Bohns Michalowski, Augusto Oliveira Silva et autres

High-risk neuroblastoma requires intensive multimodal therapy, and autologous hematopoietic stem cell transplantation (auto-HCT) remains a key component of consolidation treatment. This consensus document updates the 2021 Brazilian recommendations for neuroblastoma transplantation, focusing on indications, eligibility criteria, conditioning regimens, and the role of …

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Hematopoietic cell transplantation outcomes in public centers in Brazil: analysis of the Brazilian Registry of Hematopoietic Cell Transplantation and Cellular Therapy, 2012–2024

Anderson João Simione, CA Silva, Nelson Hamerschlak, Afonso Vigorito et autres

This study provides a national overview of hematopoietic cell transplantation (HCT) outcomes in the Brazil’s public healthcare network, using data consolidated in the Brazilian Registry of Hematopoietic Cell Transplantation and Cellular Therapy (RBTCH-TC). A total of 5,923 first HCTs performed between 2012 …

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Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia

Ana Luiza De Melo Rodrigues, A Seber, Luciana Santos Domingues, Victor Gottardello Zecchin et autres

Acute myeloid leukemia (AML) accounts for 15% to 20% of pediatric acute leukemia cases. Treatment failure is influenced by both genetic risk and response to therapy1,2,3,4. Although the initial remission rate exceeds 90%, more than 30-40% of children with AML die of …

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Retinoblastoma

Paulo Klinger, Cláudio Galvão de Castro Junior, Antonella Adriana Zanette, Neviçolino Pereira de Carvalho et autres

Retinoblastoma is the most common form of ocular cancer in children, with an estimated prevalence of one in every 15,000 to 20,000 births. Although it accounts for only 3% of pediatric neoplasms, its impact is significant in children under 5 years of …

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