Anand Trip

Nimodipine for acute optic neuritis

Olivia Fox, Anand Trip

Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein–associated disease

Alessia Bianchi, Rosa Cortese, Ferrán Prados, Carmen Tur et autres

Background: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, the involvement of the optic chiasm (OC) …

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Multiple Sclerosis and Demyelinating Diseases

Siobhan M Leary, Wallace Brownlee, Noreen Barker, Declan Chard et autres

Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system (CNS). This chapter outlines the features of multiple sclerosis and reviews the current practice in diagnosis and management. Multiple sclerosis is the most common cause of neurological disability in young …

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Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort

Frederike Cosima Oertel, Julia Krämer, Seyedamirhosein Motamedi, Azeen Keihani et autres

Background and Objectives With the increasing use of visually evoked potentials (VEPs) as quantitative outcome parameters for myelin in clinical trials, an in-depth understanding of longitudinal VEP latency changes and their prognostic potential for subsequent neuronal loss will be required. In this …

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Differentiating Multiple Sclerosis From AQP4-Neuromyelitis Optica Spectrum Disorder and MOG-Antibody Disease With Imaging

Rosa Cortese, Ferrán Prados, Carmen Tur, Alessia Bianchi et autres

Background and Objectives Relapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody–positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) may have overlapping clinical features. There is an unmet need for imaging markers that differentiate between them when serologic testing is …

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Post Vaccination Optic Neuritis: Observations From the SARS-CoV-2 Pandemic

Lidia Martinez Alvarez, Yan Ning Neo, Indran Davagnanam, Michael Ashenhurst et autres

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Persistent psychotic symptoms following COVID-19 infection

Soon Tjin Lim, Benjamin Janaway, Harry Costello, Anand Trip et autres

To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been reports of patients developing transient delirium (with and without hypoxia) after COVID-19 infection as well as other neurological manifestations. …

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10. An unusual cause for a headache

Dalia Ludwig, Shahir Hamdulay, Anand Trip, Miren Aizpurua

Introduction: Primary central nervous system vasculitis is a rare but important disease to consider in a patient who presents with headache, cognitive impairment and neurological deficit in the absence of systemic disease. As rheumatologists central nervous system vasculitis in the context of …

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New oral drugs for the treatment of multiple sclerosis

Declan Chard, Anand Trip, Jeremy Chataway

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Two different presentations, one diagnosis

Gavin McCluskey, Chandni K Rajani, Gareth Lewis, Philip Gardiner et autres

Acute confusion and hyponatraemia are common presentations in acute medicine. We report two cases of anti-voltage gated potassium channel (VGKC) antibody-related limbic encephalitis highlighting the variable presentation of this condition. Both patients were thoroughly investigated with MRI scan of brain, lumbar puncture, …

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Management of neuropsychiatric symptoms in multiple sclerosis

Andrew Sommerlad, Gary Price, Anand Trip

Abstract Multiple sclerosis is associated with a high prevalence of psychiatric comorbidity, including affective, psychotic and cognitive disorders. In this review, Dr Sommerlad and colleagues discuss the epidemiology, aetiology and management of neuropsychiatric symptoms in multiple sclerosis, using case vignettes to demonstrate …

A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials

Andrew Henderson, Daniel R. Altmann, Anand Trip, Constantinos Kallis et autres

Following an episode of optic neuritis, thinning of the retinal nerve fibre layer, which indicates axonal loss, is observed using optical coherence tomography. The longitudinal course of the retinal changes has not been well characterized. We performed a serial optical coherence tomography …

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