Accès ouvert
2025
preprint
OpenAlex
Xuejing Liu, Dongqiang Yuan, Yingjun Luo, Xiaofang Tang et autres
ABSTRACT BACKGROUND Endothelial cell (EC) dysfunction is a cause and consequence of vascular inflammation and lipid dysregulation in atherosclerosis, yet the molecular drivers linking EC dysfunction to systemic metabolic derangements remain incompletely understood. Moreover, whether inhibiting an endogenous gene in ECs can …
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Accès ouvert
2025
article
OpenAlex
Fang Chen, Dandan Zhao, Yongfang Xu, Yi qin Zhang et autres
We reported that an acquired miR-142 deficit transforms chronic phase (CP) chronic myeloid leukemia (CML) leukemic stem cells (LSCs) into blast crisis (BC) LSCs. Given the role of miR-142 in the development and activity of the immune system, we postulated that this …
us, cn
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2023
conference-abstract
OpenAlex
Fang Chen, Dandan Zhao, Yi Zhang, Yongfang Xu et autres
CML may evolve from a chronic phase (CP) into blast crisis (BC), but the underlying mechanisms of the transformation remain to be fully elucidated. We reported that microRNA (miR)-142 is downregulated in BC compared with CP patients; and in a murine model …
us, cn
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Accès ouvert
2022
article
OpenAlex
Sierra N. Henson, Evan A. Elko, Piotr Swiderski, Yong H. Liang et autres
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2022
article
OpenAlex
Lucy Y. Ghoda, Ebtesam H. O. Nafie, Elizabeth Bloom‐Saldana, Patrick T. Fueger et autres
Introduction: Acute myeloid leukemia (AML) is a lethal hematopoietic malignancy, characterized by the accumulation of clonal myeloid progenitor cells arrested in development. AML patients have dismal survival odds with a 5-year overall survival (2011 - 2017) of 29.5% (SEER). The main cause …
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