2016
article
OpenAlex
Katharina Mederle, Bernhard Gess, Florentina Pluteanu, Jelena Plačkić et autres
AIMS: The angiotensin II type 1 receptor-associated protein (Atrap) is highly expressed in the heart, but its function in the heart is unknown. We hypothesized that cardiac Atrap may interact with proteins other than the AT1 receptor. METHODS AND RESULTS: To identify …
de
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2015
article
OpenAlex
Katharina Mederle, Manuel Meurer, Hayo Castrop, Klaus Höcherl
Thromboxane (Tx) A2 has been suggested to be involved in the development of sepsis-induced acute kidney injury (AKI). Therefore, we investigated the impact of cyclooxygenase (COX)-1 and COX-2 activity on lipopolysaccharide (LPS)-induced renal TxA2 formation, and on endotoxemia-induced AKI in mice. Injection …
de
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2014
article
OpenAlex
Katharina Mederle, Bernhard Gess, Hayo Castrop
The angiotensin II type 1 receptor‐associated protein (Atrap) is highly expressed in the heart. We hypothesized that cardiac Atrap may interact with proteins other than the AT1 receptor. To identify novel interacting partners of Atrap, we performed pull‐down assays. In 3 independent …
de
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Accès ouvert
2013
article
OpenAlex
Katharina Mederle, Frank Schweda, Veronika Kattler, Elisabeth Doblinger et autres
INTRODUCTION: Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors, such as angiotensin II. The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro. We hypothesized …
de, jp
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Accès ouvert
2013
article
OpenAlex
Chun‐Fu Lai, Shuei‐Liong Lin, Wen‐Chu Chiang, Y.-M. Chen et autres
Introduction and Aims: Clinical studies have demonstrated the risk of chronic kidney disease after the occurrence of an acute kidney injury (AKI).Experimental works indicate that AKI result in incomplete repair, persistent tubulointerstitial inflammation and fibrosis.Cysteine-rich protein 61 (Cyr61), a secreted matrix-associated protein, …
tw, kr, de, il, jp, es, cn, fr, Égypte, ru, us
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2013
article
OpenAlex
Katharina Mederle, Hayo Castrop, Frank Schweda, Klaus Höcherl
In this study, we investigated the impact of COX‐1‐ and COX‐2‐derived prostanoids on lipopolysaccharide (LPS)‐induced decrease in glomerular filtration rate (GFR) in mice. Injection of LPS (3 mg/kg; i.p.; n=8) decreased GFR and the amount of thrombocytes to about 50% of basal …
de
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2013
article
OpenAlex
Katharina Mederle, Elisabeth Doblinger, Veronika Kattler, Klaus Höcherl et autres
Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors. Altered expression of angiotensin receptors might contribute to reduced vascular tone during sepsis. The AT1 receptor‐associated protein 1 (ARAP1) is expressed in vascular smooth muscle cells and increases the surface …
de
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2013
article
OpenAlex
Katharina Mederle, Kerim Mutig, Alexander Paliege, Isabel Anna Carota et autres
WNK3 kinase is expressed throughout the nephron and acts as a positive regulator of NKCC2 and NCC in vitro. Here we addressed the in vivo relevance of WNK3 using WNK3-deficient mice. WNK3-/- mice were viable and showed no gross abnormalities. The net …
de
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Accès ouvert
2013
dissertation
OpenAlex
Katharina Mederle
Die Reabsorptionsprozesse der Niere leisten einen essentiellen Beitrag zur Salz-, Wasser- und Blutdruckhomöostase. Die Erforschung dieser Mechanismen ist ein wichtiges Element der Hypertonietherapie. In diesem Zusammenhang sind die sogenannten WNK-Kinasen, die die Aktivität renaler Ionentransporter regulieren, von besonderem Interesse. Die WNK3-Kinase spielt …
de
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2012
article
OpenAlex
Katharina Mederle, Mona Oppermann, Alexander Paliege, Hayo Castrop
Wnk3 kinase is expressed throughout the nephron and acts as a positive regulator of NKCC2 and NCC in vitro. Here we addressed the in vivo relevance of Wnk3 by the use of Wnk3‐deficient mice. Wnk3−/− mice were viable and showed no gross …
de
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2012
article
OpenAlex
Elisabeth Doblinger, Klaus Höcherl, Katharina Mederle, Veronika Kattler et autres
Arap1 is a protein that interacts with angiotensin II type 1 (AT(1)) receptors and facilitates increased AT(1) receptor surface expression in vitro. In the present study, we assessed the tissue localization and regulation of Arap1 in vivo. Arap1 was found in various …
de, dk
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